GEO DataSets

(Submitter supplied) The application of mechanical insults to the spinal cord results in profound cellular and molecular changes, including the induction of neuronal cell death and altered gene expression profiles. We demonstrated that spinal cord cells undergo cell death in response to cyclic tensile stresses, which were dose- and time- dependent. In addition, we have identified the up regulation of various genes, in particular of the MAPK pathway, which may be involved in this cellular response. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

7 Samples

Download data: CEL, CHP

(Submitter supplied) The retina is often subjected to tractional forces in a variety of conditions, for instance, pathological myopia, proliferative vitreoretinopathy. As the predominant glial element in the sensory retina, Muller cells are responsible for the homeostatic and metabolic support of retinal neurons and active players in virtually all forms of retinal injury and disease. Besides, Muller cells span the entire retinal thickness, extending from the inner to the outer limiting membranes, with cell bodies located in the inner nuclear layer and lateral processes expanding into the plexiform layers of the tissue. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL, CHP

(Submitter supplied) Tissue Factor Pathway Inhibitor-2 is Induced by Fluid Shear Stress in Vascular Smooth Muscle Cells and Affects Cell Proliferation and Survival Introduction: Vascular smooth muscle cells (SMCs) are exposed to fluid shear stress (FSS) after interventional procedures such as balloon-angioplasty. Whereas the effects of hemodynamic forces on endothelial cells are explored in detail, the influence of FSS on smooth muscle cell function is poorly characterized. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

6 Samples

Download data: CEL

(Submitter supplied) Summary: Spinal cord injury (SCI) is a damage to the spinal cord induced by trauma or desease resulting in a loss of mobility or feeling. SCI is characterized by a primary mechanical injury followed by a secondary injury in which several molecular events are altered in the spinal cord often resulting in loss of neuronal function. Hypothesis: Spinal cord injury (SCI) induces a cascade of molecular events including the activation of genes associated with transcription factors, inflammation, oxidative stress, ionic imbalance, apoptosis and neuroregeneration which suggests the existance of endogenous reparative attempts. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS63 GDS259 GDS339 GDS869 GDS870 GDS871 GDS872 GDS873 GDS874

Platforms:

GPL86 GPL85 GPL87

544 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 protocol, 7 time sets

Platform:

GPL87

Series:

GSE464

48 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 protocol, 7 time sets

Platform:

GPL86

Series:

GSE464

47 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol, 7 time sets

Platform:

GPL85

Series:

GSE464

52 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 protocol, 6 time sets

Platform:

GPL87

Series:

GSE464

43 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 protocol, 7 time sets

Platform:

GPL86

Series:

GSE464

52 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol, 7 time sets

Platform:

GPL85

Series:

GSE464

55 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol, 11 time sets

Platform:

GPL87

Series:

GSE464

75 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol, 11 time sets

Platform:

GPL86

Series:

GSE464

77 Samples

Download data: CEL

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol, 11 time sets

Platform:

GPL85

Series:

GSE464

89 Samples

Download data: CEL

(Submitter supplied) The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the lamina cribrosa may play a role in this process but the precise cellular responses to mechanical forces in this region are unknown. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

2 Samples

Download data

(Submitter supplied) To further development of our gene expression approach to biodosimetry, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish radiation dose across an exposure range relevant for medical decision-making in a radiological emergency. Human peripheral blood from healthy donors was irradiated ex vivo, and a 74-gene consensus signature was identified that distinguished between four radiation doses (0.5, 2, 5 and 8 Gy) and control samples. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

6 Samples

Download data: TXT

(Submitter supplied) A screen of 5 anti-inflammatory compounds for their effects in explanted, cultured rat spinal cord slices. All injured (explanted) cords are cultured for 4 hrs. Keywords: ordered

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL479

21 Samples

Download data

(Submitter supplied) Here we compare the gene expression profiles of two distict, fluorescently identified neuronal populations, the motor neruons (MN) and the decending commissural interneurons (dCIN) of the neonatal rat spinal cord isolated with laser microdissection. These two populations participate in the neuronal networks in the spinal cord where they have destinct functions in shaping (dCINs) and transferring the output to the muscles (MNs) during locomotion. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL88

22 Samples

Download data: CEL

(Submitter supplied) Analysis of expression changes in prelabeled laser-microdissected thoracic propriospinal neurons at different times after low-thoracic spinal cord transection in adult rats.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

24 Samples

Download data: CEL

(Submitter supplied) The mechanism of morphine tolerance remains unclear, and lncRNA have been promising molecule in many pathophysiological processes. However, the role of lncRNA on morphine tolerance hasn’t been explored yet. So we explore this issue, and our results indicated that the expression profiles of lncRNAs have changed in morphine tolerance rats as compared with normal rats, and among those, some differentially expressed lncRNAs might be new therapeutic targets for morphine tolerance.

Organism:

Rattus norvegicus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL15690

10 Samples

Download data: TXT

(Submitter supplied) This study compared the microRNA expression in mouse fetal spinal cord at day 13.5 and newborn mouse spinal cord.

Organism:

Rattus norvegicus; Homo sapiens; Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL18894

2 Samples

Download data: TXT