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Links from GEO DataSets

Items: 14

1.

Expression data of lung tissues from ICR mice treated with or without single-walled carbon nanotubes (SWCNTs)

(Submitter supplied) The SWCNTs can induce airway hyper-responsiveness (AHR) and chronic obstructive pulmonary disease (COPD)-like changes in mice model. The SWCNTs can induce clusters of proteinases, chemokines/cytokines, and macrophage receptors triggered signaling, which might play critical roles in the SWCNTs-induced pathological changes, including chronic inflammation and tissues remodeling. We used microarrays to detail the global programme of gene expression underlying and identified distinct classes of up-regulated genes during this process.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE22856
ID:
200022856
2.

Gene expression profiles in rat lung following intratracheal instillation with short size single-wall and multi-wall carbon nanotubes

(Submitter supplied) To further development of our gene expression approach to assess the effects of manufactured nanomaterials at the transcriptional level, we have employed whole genome microarray expression profiling to discuss the differences of the pulmonary and pleural
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL7294
15 Samples
Download data: TXT
Series
Accession:
GSE75148
ID:
200075148
3.

RAW264.7 gene expression after exposure to 1-50ug/ml AF-SWCNT-24 hours

(Submitter supplied) Single-walled carbon nanotubes (SWCNTs) are being explored and used for a wide range of applications in industrial and medical sectors, and the increasing exposure of SWCNTs necessitate the studies of their potential environmental and health effects. Considerable efforts have been made to improve the dispersion of SWCNTs by chemical modifications. The present study was designed to determine if the acid functionalization of SWCNTs enhanced the toxicity and more efforts were made to understand the molecular mechanisms. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL8799 GPL9961
9 Samples
Download data: LSR
Series
Accession:
GSE20021
ID:
200020021
4.

Gene expression profiles in rat lung following intratracheal instillation with impurity-free single-wall carbon nanotubes

(Submitter supplied) To further development of our gene expression approach to assess the effects of manufactured nanomaterials at the transcriptional level, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish characterization of physicochemical properties of impurity-free single-wall carbon nanotubes (SWCNTs). We have prepared two types of dispersed the SWCNTs, namely relatively small bundles and a short linear shape (CNT-1) and large bundles and a long linear shape (CNT-2), and attempted to characterize time-dependent changes in the gene expression of lung tissues until 90 days after intratracheal instillation with SWCNTs suspensions at 0.4 mg injected dose per rat.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL7294
15 Samples
Download data: TXT
Series
Accession:
GSE61483
ID:
200061483
5.

Gene expression profiles in rat alveolar macrophages exposure to impurity-free single-wall carbon nanotubes

(Submitter supplied) To further development of our gene expression approach to assess the effects of manufactured nanomaterials at the transcriptional level, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish characterization of physicochemical properties of impurity-free single-wall carbon nanotubes (SWCNTs), namely, relatively small bundles and a short linear shape (CNT-1) and large bundles and a long linear shape (CNT-2).
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL7294
3 Samples
Download data: TAR
Series
Accession:
GSE61319
ID:
200061319
6.

Expression data from the lungs of Scnn1b-Transgenic and wild-type mice

(Submitter supplied) Airway mucus obstruction triggers macrophage activation and MMP12-dependent emphysema
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE49373
ID:
200049373
7.

Gene expression profiles in rat lung following intratracheal instillation with single-wall carbon nanotubes

(Submitter supplied) Gene expression profiling of the rat lung following intratracheal instillation with single-wall carbon nanotubes (SWCNTs) was employed to gain insights into these molecular events. We attempted to characterize time-dependent changes in the gene expression until 754 days after intratracheal instillation with SWCNTs suspensions at 0.2 mg (L-SWCNT) and 0.4 mg (H-SWCNT) injected dose per rat, and to identify the shift from the acute-phase to the chronic-phase phase on the basis of evaluation at the molecular level.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL7294
21 Samples
Download data: TXT
Series
Accession:
GSE50664
ID:
200050664
8.

Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelia cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
44 Samples
Download data: TXT
Series
Accession:
GSE47000
ID:
200047000
9.

Transcriptomic analysis of cultured lung epithelial cells exposed to multiwalled carbon nanotubes (Mitsui7)

(Submitter supplied) There is great interest in substituting animal with in vitro experimentation in human health risk assessment, but there are rather few comparisons of in vitro and in vivo biological responses to engineered nanomaterials (ENM). We used high-content genomics tools, to compare in vivo pulmonary responses of multiwalled carbon nanotubes (MWCNT) to those in vitro in cultured lung epithelial cells at the global transcriptomic level. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
22 Samples
Download data: TXT
Series
Accession:
GSE46999
ID:
200046999
10.

Transcriptomic analysis of mouse lung tissue exposed to multiwalled carbon nanotubes (Mitsui7)

(Submitter supplied) There is great interest in substituting animal with in vitro experimentation in human health risk assessment, but there are rather few comparisons of in vitro and in vivo biological responses to engineered nanomaterials (ENM). We used high-content genomics tools, to compare in vivo pulmonary responses of multiwalled carbon nanotubes (MWCNT) to those in vitro in cultured lung epithelial cells at the global transcriptomic level. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
22 Samples
Download data: TXT
Series
Accession:
GSE46998
ID:
200046998
11.

Transcriptional profle of bronchoalveolar cells in sarcoidosis

(Submitter supplied) Introduction: Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased approach to identify pathways activated in alveolar macrophages—a key immuno-inflammatory cell in the lung—can shed light on the pathogenesis of this complex disease. Methods: We recruited 15 patients with various stages of sarcoidosis and 12 healthy controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
27 Samples
Download data: CEL
Series
Accession:
GSE75023
ID:
200075023
12.

Carbon nanotubes, but not graphene oxide, trigger chemokine production in primary human macrophages via MyD88 dependent NF-kB Pathway

(Submitter supplied) The growing medical application of engineered nanomaterials (ENMs) necessitates better understanding of their molecular toxicity mechanisms governing immune effects. In the present study, a comprehensive mechanistic in vitro assessment of two carbon-based ENMs, single-walled carbon nanotubes (SWCNTs) and graphene oxide (GO), was performed using primary human monocyte-derived macrophages (HMDM) as a model. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15803
17 Samples
Download data: CEL
Series
Accession:
GSE83516
ID:
200083516
13.

Multi-walled carbon nanotube-induced gene expression in vitro

(Submitter supplied) There is a current interest in reducing the in vivo toxicity testing of nanomaterials in animals by increasing toxicity testing using in vitro cellular assays; however, toxicological results are seldom concordant between in vivo and in vitro models. This study compared global multi-walled carbon nanotube (MWCNT)-induced gene expression from human lung epithelial and microvascular endothelial cells in monoculture and coculture with gene expression from mouse lungs exposed to MWCNT. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13607
72 Samples
Download data: TXT
Series
Accession:
GSE129640
ID:
200129640
14.

Expression profiling of mice exposed to multiwalled carbon nanotubes

(Submitter supplied) Mice were aspirated with multiwalled carbon nanotubes in four doses ranging from 10 µg to 80 µg, plus control, and sacrificed after 1, 7, 28, and 56 days. RNA was extracted from the lungs and expression profilling by microarray was performed.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
160 Samples
Download data: TXT
Series
Accession:
GSE29042
ID:
200029042
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