GEO DataSets

(Submitter supplied) In this study we have analyzed gene expression and metabolite levels in the livers of male and female Zucker diabetic fatty (ZDF) rats. We speculated that the sex different development of diabetes in the ZDF animals presents the opportunity to relate gender to diabetes (since only males become diabetic on normal diet). In this model one can search for parameters that distinguish females fed normal diet compared to high fat diet (i.e. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6528

4 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6528

8 Samples

Download data: GPR

(Submitter supplied) In this study we have analyzed gene expression and metabolite levels in the livers of male and female Zucker diabetic fatty (ZDF) rats. We speculated that the sex different development of diabetes in the ZDF animals presents the opportunity to relate gender to diabetes (since only males become diabetic on normal diet). In this model one can search for parameters that distinguish females fed normal diet compared to high fat diet (i.e. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6528

4 Samples

Download data: GPR

(Submitter supplied) Gene expression profiles in tissues of Zucker diabetic fatty (ZDF) rats compared with age matched Zucker lean control (ZLC) rats. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1767

Platform:

GPL1002

24 Samples

Download data

Analysis of adipose, skeletal muscle, and liver tissues of Zucker diabetic fatty animals at pre-diabetic and diabetic stages. ZDF animals have a mutated leptin receptor. Results provide insight into the molecular mechanisms responsible for insulin resistance and progression to type 2 diabetes.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 2 age, 3 tissue sets

Platform:

GPL1002

Series:

GSE1080

24 Samples

Download data

(Submitter supplied) High fat diet (HF) rodent models have contributed significantly to the dissection of the pathophysiology of the insulin resistance syndrome, but their phenotype varies distinctly between different studies. Here, we have analyzed gene expression patterns in livers of animals fed with different HF with varying fatty acid compositions. Keywords: diet-gene interaction

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1307

Platform:

GPL1355

10 Samples

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Expression profiling of liver from Wistar males fed for 12 weeks with one of 4 different high fat diets, each differing in fatty acid composition. The different fat sources used were lard, olive oil, coconut fat, and cod liver oil.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 protocol sets

Platform:

GPL1355

Series:

GSE3512

10 Samples

Download data

(Submitter supplied) We report on the characterization of lipogenic tissue transcriptional networks that support physiological responses of obese rats to a lipid-lowering bioactive food compound, R-a-lipoic acid (LA). Nine-week old male ZDF (fa/fa) rats were fed a chow diet supplemented with 3 g LA per kg diet or pair fed for two weeks. At the end of the trial, high-quality RNA was extracted from the liver and epididymal fat and subjected to transcriptome analysis using RNA-Seq technology. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL10287

16 Samples

Download data: TSV, TXT

(Submitter supplied) In the present study we tested the hypothesis that male and female rat livers respond differently to a change in nutrient availability or to insulin treatment. We compared hepatic gene expression, hepatic glycogen and glucose output, insulin sensitivity and amino acids, using healthy rats. Keywords: Hepatic gene expression, sex-differences

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6528

4 Samples

Download data: GPR

(Submitter supplied) Hepatic gene expression variations and sex-differences due to high-fat diet consumption using the Collaborative Cross mouse model

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

84 Samples

Download data: FPKM_TRACKING