GEO DataSets

(Submitter supplied) The effects of fasting have been studied extensively, predominantly on isolated processes, within a specific organ. No comprehensive study of the adaptations was available for different organs, let alone interrelating them, which left the understanding of the body’s orchestration of fasting response limited. The gene expression profiles of brain, small intestine, kidney, liver and skeletal muscle were therefore studied in mice subjected to short, moderate and prolonged fasting. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3893

Platform:

GPL11012

122 Samples

Download data: TXT

Analysis of brain, small intestine, kidney, liver, and skeletal muscle subjected to 0-72 hrs of fasting. Adapting to starvation requires an interorgan integration of metabolic activity to protect vital organs. Results provide insight into molecular mechanisms underlying this adaptive response.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 5 time, 5 tissue sets

Platform:

GPL11012

Series:

GSE24504

122 Samples

Download data: TXT

(Submitter supplied) The aim of the study was to investigate how short-term fasting affects whole-body energy homeostasis and skeletal muscle energy/nutrient-sensing pathways and transcriptome in humans. For this purpose, twelve young healthy men were studied during a 24-hour fast. Skeletal muscle biopsies were collected and analyzed at baseline and after 4, 10 and 24h of fasting. As expected, fasting induced a time-dependent decrease in plasma insulin and leptin levels, whereas levels of ketone bodies and free fatty acids increased. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5473

Platform:

GPL10558

48 Samples

Download data: TXT

Analysis of skeletal muscle biopsies collected at 1.5, 4, 10, and 24hr post-meal time from healthy young men subjected to a 24hr fast. Results provide insight into the molecular mechanisms underlying metabolic adaptation to fasting in healthy humans.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 12 individual, 4 time sets

Platform:

GPL10558

Series:

GSE55924

48 Samples

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(Submitter supplied) This study integrates global transcriptional profiling and the metabolic perturbation induced by fasting and re-feeding. Genetic control of growth and development should be revealed by systematic modeling of metabolic and regulatory pathways. Chicken oligo arrays were used for transcriptional profiling in two time-course experiments. Two critical developmental stages were chosen: immediately after hatchling (Wk1) and prior to marketing of broiler chickens (Wk6). more...

Organism:

Gallus gallus

Type:

Expression profiling by array

Platform:

GPL6049

80 Samples

Download data: GPR

(Submitter supplied) Peroxisome proliferator-activated receptor alpha (PPARα) is a key regulator of hepatic fat oxidation that serves as an energy source during starvation. Vanin-1 has been described as a putative PPARα target gene in liver, but its function in hepatic lipid metabolism is unknown. We investigated the regulation of vanin-1, and total vanin activity, by PPARα in mice and humans. Furthermore, the function of vanin-1 in the development of hepatic steatosis in response to starvation was examined in Vnn1 deficient mice, and in rats treated with an inhibitor of vanin activity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4872

Platform:

GPL11533

16 Samples

Download data: CEL

Analysis of liver from vanin-1 KOs fasted for 24 hrs. Vanin-1 is highly expressed in liver compared to other tissues. In the fasted state, liver switches to fatty acid oxidation and glucose production. Results provide insight into the role of vanin-1 in hepatic lipid metabolism during starvation.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:

GPL11533

Series:

GSE51712

16 Samples

Download data: CEL

(Submitter supplied) To identify genes whose expression is under the strict dependence of hepatocyte PPARa activity, we used a mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to their liver WT littermates (albumin-Cre-/- Pparaflox/flox or LWT) fed ad libitum or fasted for 24 hours.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL21810

24 Samples

Download data: TXT

(Submitter supplied) Peroxisome Proliferator-Activated receptor α (PPARα) and cAMP-Responsive Element Binding Protein 3-Like 3 (CREB3L3) are transcription factors involved in the regulation of lipid metabolism in the liver. The aim of the present study was to characterize the interrelationship between PPARα and CREB3L3 in regulating hepatic gene expression. Male wildtype, PPARα-/-, CREB3L3-/- and combined PPARα/CREB3L3-/- mice were subjected to a 16-hour fast or 4 days of ketogenic diet. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11533

30 Samples

Download data: CEL

(Submitter supplied) RNA-seq analysis was applied in two independent batches, each one in triplicate samples of HeLa cells in nutrient-rich and nutrient-deprived media

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

12 Samples

Download data: TXT

(Submitter supplied) Nuclear receptor activation in liver leads to coordinated alteration of the expression of multiple gene products with attendant phenotypic changes of hepatocytes. Peroxisome proliferators including endogenous fatty acids, environmental chemicals, and drugs induce a multi-enzyme metabolic response that affects lipid and fatty acid processing. We studied the signaling network for the peroxisome proliferator-associated receptor alpha (PPARα) in primary human hepatocytes using the selective PPARα ligand, GW7647. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13158

120 Samples

Download data: CEL

(Submitter supplied) Gene expression regulation of transporters and phase I/II metabolic enzymes in murine small intestine during fasting Keywords: metabolic state analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2934

Platform:

GPL339

12 Samples

Download data: CEL

Analysis of PPARalpha deficient small intestines after a 24 hour fast. PPARalpha is a fatty acid-activated transcription factor. Results provide insight into transport function and phase I/II metabolism in the small intestine during fasting and the role of PPARalpha in the response to fasting.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 protocol sets

Platform:

GPL339

Series:

GSE6864

12 Samples

Download data: CEL

(Submitter supplied) Mice used in this study were 129/sv males, 8-15 weeks of age, which were housed individually and received water ad libitum. Normal fed animals were fed before and during the 48h experiment with standard food ad libitum. Sugar fed animals were fed before the experiment with standard food ad libitum and during the 48h experiment with 50% (w/v) sugar solution (40% glucose, 10% sucrose). Mice were killed by CO2 asphyxiation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL765

60 Samples

Download data

(Submitter supplied) Mice used in this study were 129/sv males, 8-15 weeks of age, which were housed individually and received water ad libitum. Normal fed animals were fed before and during the 48h experiment with standard food ad libitum. Starved animals were fed before the experiment with standard food ad libitum and were starved during the 24h experiment. Mice were killed by CO2 asphyxiation. The livers were snap-frozen in liquid nitrogen and stored at -80 degrees C. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL765

24 Samples

Download data

(Submitter supplied) Mice used in this study were 129/sv males, 8-15 weeks of age, which were housed individually and received water ad libitum. Normal fed animals were fed before and during the 48h experiment with standard food ad libitum. Starved animals were fed before the experiment with standard food ad libitum and were starved during the 48h experiment. Mice were killed by CO2 asphyxiation. The livers were snap-frozen in liquid nitrogen and stored at -80 degrees C. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL765

24 Samples

Download data

(Submitter supplied) Mice used in this study were 129/sv males, 8-15 weeks of age, which were housed individually and received water ad libitum. Normal fed animals were fed before and during the 48h experiment with standard food ad libitum. Sugar fed animals were fed before the experiment with standard food ad libitum and during the 48h experiment with 50% (w/v) sugar solution (40% glucose, 10% sucrose). Mice were killed by CO2 asphyxiation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL765

12 Samples

Download data

(Submitter supplied) cDNA microarrays based on the Lion Bioscience (Heidelberg, Germany) clone collection Mouse ArrayTag(r) set A and B. Each microarray contains 43200 features within two seperate subarrays with each 21600 spots and 20188 spots containing gene probes. The ID is organized like this: Letter "A" or "B" to distiguish both subarrays from each other, followed by the # sign an a running index for each subarray (1 to 21600). more...

Organism:

Mus musculus

4 Series

60 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

32 Samples

Download data: CEL

(Submitter supplied) Identified genes deregulated in mouse primary hepatocytes after modulation of expression/activity of FOXA2 and FXR in glucagon or insulin state

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

24 Samples

Download data: CEL