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Links from GEO DataSets

Items: 20

1.

Control of oxidative stress by miRNA and impact on ovarian tumorigenesis

(Submitter supplied) Transcriptome analysis of high-grade human ovarian adenocarcinomas. The hypothesis tested in the present study was that two reciprocal pathways, namely oxidative stress response and fibrosis, enable to build a hierarchical cluster of ovarian patients.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
107 Samples
Download data: CEL
Series
Accession:
GSE26193
ID:
200026193
2.

miRNA analysis of murine fibroblasts subjected to acute oxidative stress

(Submitter supplied) Analysis of miRNA modulated by H2O2 treatment in murine fibroblasts. The hypothesis in the present study is that stress balance the level of some miRNAs. These particular miRNAs may target key proteins involved in stress and thus modulate cellular response to stress.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL8180
14 Samples
Download data: TXT
Series
Accession:
GSE26194
ID:
200026194
3.

Genome-wide analysis of transfection of miR-141 or miR-200c in murine fibroblasts subjected to acute oxidative stress

(Submitter supplied) Analysis of abnormal cellular response to stress after overexpression of stress-induced microRNAs. The hypothesis tested in the present study was that miR-141 or miR-200c may influence transcription of stress-pathways related genes
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6105
4 Samples
Download data: TXT
Series
Accession:
GSE26113
ID:
200026113
4.

miRNA Expression Profiling in Ovarian Cell Lines compared to pooled commercial RNA samples

(Submitter supplied) We investigated whether levels of serum microRNAs (miRNAs) could discriminate women with high-grade serous ovarian epithelial cancer (SEOC) from age matched healthy volunteers. miRNA expression profiling was performed on 4 SEOC cell lines and normal human ovarian surface epithelial cells (HOSE). miR-182, miR-200a, b and c were highly overexpressed in the SEOC cell lines. miR-103, miR-92a and miR-638 displayed relatively invariant expression and with RNU48, were assessed, as putative serum miRNA normalizers. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL15257
5 Samples
Download data: GAL, SPOT
Series
Accession:
GSE35951
ID:
200035951
5.

Expression data from HK2 proximal tubule cells transduced with shPGC-1alpha compared to cells transduced with control shRNA

(Submitter supplied) To identify regulation of genes involved in lipid and glycogen metabolism by PGC-1alpha We used whole genome expression analysis to explore the mechanism of lipid and glycogen accumulation in proximal tubule cells following suppression of PGC-1alpha expression.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
6 Samples
Download data: CEL
Series
Accession:
GSE57994
ID:
200057994
6.

A PGC-1alpha-dependent decrease in mitochondrial oxidative metabolism in muscle of humans with inherited insulin resistance

(Submitter supplied) We used microarrays to assess gene expression profiling of 6 patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR) and 10 matched healthy controls
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4897
Platform:
GPL571
16 Samples
Download data: CEL
Series
Accession:
GSE36297
ID:
200036297
7.
Full record GDS4897

Skeletal muscle of patients with inherited insulin resistance

Analysis of muscle from patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR). This mutation is associated with inherited insulin resistance. Results provide insight into molecular mechanisms underlying insulin resistance in skeletal muscle.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL571
Series:
GSE36297
16 Samples
Download data: CEL
DataSet
Accession:
GDS4897
ID:
4897
8.

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(Submitter supplied) The study aimed to analyse the transcriptome of mouse cancer cells while in primary tumor, in circulation and after homing to metastatic site. The model used here is the 4T1 cancer cell orthotopic model.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
3 Samples
Download data: TXT
Series
Accession:
GSE37344
ID:
200037344
9.

A transcriptional regulatory network connects mitochondrial biogenesis and metabolic shift with stem cell commitment to hepatic differentiation

(Submitter supplied) Mitochondrial biogenesis and metabolism recently emerged as critical modulators of stemness properties and differentiation programmes. The increase in mitochondrial biogenesis and metabolic shift toward increased oxidative phosphorylations (OXPHOS) appear as hallmarks of stem cell differentiation processes. While several mechanisms support the involvement of mitochondrial biogenesis and function in the regulation of stem cell differentiation, the mechanisms triggering mitochondrial biogenesis in the context of cell differentiation remain elusive. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE75184
ID:
200075184
10.

lipin 1beta overexpression in mouse liver

(Submitter supplied) Mutations in the gene encoding lipin 1 cause hepatic steatosis in fld mice, a genetic model of lipodystrophy. Lipin 1 appears to be highly involved in the control of fatty acid metabolism. Lipin 1 is most often located in the nucleus, but other studies suggest that lipin also has effects in the cytoplasm. However, the molecular function of lipin 1 is unclear. To evaluate the effects of activation of the lipin 1 system in liver, lipin 1beta was overexpressed in mouse liver using an adenoviral vector. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2291
Platform:
GPL339
4 Samples
Download data
Series
Accession:
GSE5538
ID:
200005538
11.
Full record GDS2291

Lipin 1-beta overexpression effect on the liver

Analysis of livers of transgenics overexpressing lipin 1-beta, an alternative form of lipin 1 containing a 33 amino acid insertion. Mutations in the gene encoding lipin 1 cause hepatic steatosis in fld animals, a genetic model of lipodystrophy. Results provide insight into the function of lipin 1.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE5538
4 Samples
Download data
DataSet
Accession:
GDS2291
ID:
2291
12.

mTOR pathway controls mitochondrial gene expression and respiration through the YY1/PGC-1alpha transcriptional complex

(Submitter supplied) Mitochondrial oxidative function is tightly controlled to maintain energy homeostasis in response to nutrient and hormonal signals. An important cellular component in the energy sensing response is the target of rapamycin (TOR) kinase pathway; however whether and how mTOR controls mitochondrial oxidative activity is unknown. Here, we show that mTOR kinase activity stimulates mitochondrial gene expression and oxidative function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE5332
ID:
200005332
13.

Progressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation

(Submitter supplied) Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4904
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE52550
ID:
200052550
14.
Full record GDS4904

Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle

Analysis of muscle from aged animals with muscle-specific Pgc-1α depletion. PGC-1alpha is a transcriptional coactivator of the mitochondrial gene program. Results provide insight into the role of Pgc-1α in the glucose intolerance and chronic systemic inflammation associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE52550
12 Samples
Download data: CEL
15.

Remodeling of Brown and White Adipose Tissue by NT-PGC-1α-Mediated Gene Regulation

(Submitter supplied) The β-adrenergic receptor signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β-AR activation highly induces transcriptional coactivator PGC-1α and its splice variant N-terminal (NT)-PGC-1α, promoting the transcription program of mitochondrial biogenesis and thermogenesis. In the present study, we evaluated the role of NT-PGC-1α in brown adipocyte energy metabolism by genome-wide profiling of NT-PGC-1α-responsive genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2995
4 Samples
Download data: TXT
Series
Accession:
GSE71774
ID:
200071774
16.

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α

(Submitter supplied) Mutant forms of p53 protein often possess pro-tumorigenic function, conferring increased survival and migration to tumor cells via its “gain of function” activity. Whether and how a common polymorphism in TP53 at amino acid 72 (Pro72Arg, hereafter P72 and R72) impacts this gain of function has not been determined. We show that mutant p53 enhances migration and metastasis of tumors through the ability to bind and regulate PGC-1α, and that this regulation is markedly impacted by the codon 72 polymorphism. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
11 Samples
Download data: TXT
Series
Accession:
GSE109373
ID:
200109373
17.

Oxidative phosphorylation promotes primary melanoma invasion

(Submitter supplied) Dermal invasion is a hallmark of malignant melanoma. The molecular alterations driving the progression of primary melanoma to metastatic disease have been studied extensively, whereas the early progression of non-invasive primary melanoma to an invasive state is not well understood. To elucidate the mechanisms underlying the transition from radial to vertical growth, the first step in melanoma invasion, we developed a zebrafish melanoma model in which constitutive activation of ribosomal protein S6 kinase 1 (RSK1) drives tumor invasion. more...
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14875
12 Samples
Download data: CSV
Series
Accession:
GSE144117
ID:
200144117
18.

single cell RNA-seq analysis of ovarian cancer ascites

(Submitter supplied) To understand the cellular diversity within malignant ascites, we profiled ~11,000 single cells from 22 samples by Smartseq2 and by 10x.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
10906 Samples
Download data: TSV
Series
Accession:
GSE146026
ID:
200146026
19.

Dual inhibition of Src and MEK decreases the growth of human ovarian cancer cells

(Submitter supplied) Treatment of established lines and primary ovarian cancer cultures with Src and MEK inhibitors, saracatinib and selumetinib, respectively, showed target kinase inhibition and synergistic induction of apoptosis and cell cycle arrest in vitro and tumor inhibition in xenografts.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE112371
ID:
200112371
20.

Ovarian Tumor Samples: mixed reference of 106 pooled ovarian samples vs. individual patient ovarian sample

(Submitter supplied) The goal of the study was to identify molecular subgroups that might predict clinical outcomes in serous epithelial ovarian cancer (EOC) patients. A second objective was to identify potential therapeutic targets for serous EOC based on improved understanding of the molecular diversity of the disease. Ovarian tissues and matched peripheral blood samples were prospectively obtained from sequential patients undergoing planned gynecologic surgery at Cedars-Sinai Medical Center between 1989 and 2005. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7264
172 Samples
Download data: TXT
Series
Accession:
GSE51088
ID:
200051088
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