GEO DataSets

(Submitter supplied) Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to phase-variable expression (high-frequency reversible ON/OFF switching of gene expression). In Haemophilus influenzae, Neissera Meningtidis and Neisseria Gonorrhoeae, the random switching of the modA gene, associated with a phase variable type III restriction modification (R-M) system, controls expression of a phase-variable regulon of genes (a “phasevarion”), via differential methylation of the genome in the modA ON and OFF states. more...

Organism:

Helicobacter pylori P12; Helicobacter pylori

Type:

Expression profiling by array

Platform:

GPL11628

6 Samples

Download data: TXT

(Submitter supplied) Moraxella catarrhalis contains an N6-adenine DNA-methyltransferase (ModM3), that is subject to phase variable expression (random ON/OFF switching). Phase-variable switching of DNA methyltransferase activity results in the presence or absence of methylation at a specific target sequence, leading to co-ordinated, epigenetically-regulated switching of expression of multiple genes across the genome. The suite of genes thus regulated are known as a phasevarion (phase-variable regulon). more...

Organism:

Moraxella catarrhalis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27756

6 Samples

Download data: TXT

(Submitter supplied) Helicobacter pylori colonizes the gastric epithelium and is the leading cause of gastric adenocarcinoma. There is increasing evidence that DNA methylation regulates gene expression in addition to its role in genome protection. In this study, we characterize the impact of acidity, the Two-Component System (TCS) ArsRS, Autoinducer-2, and the Type I m6A DNA methyltransferase HsdM1 (HP0463) on the Helicobacter pylori methylome. more...

Organism:

Helicobacter pylori

Type:

Other

Platform:

GPL33724

6 Samples

Download data: CSV, GFF

(Submitter supplied) Actinobacillus pleuropneumoniae is the cause of porcine pleuropneumonia, a severe respiratory tract infection that is responsible for major economic losses to the swine industry. Many host-adapted bacterial pathogens encode systems known as phasevarions (phase-variable regulons). Phasevarions result from variable expression of cytoplasmic DNA methyltransferases. Variable expression results in genome-wide methylation differences within a bacterial population, leading to altered expression of multiple genes via epigenetic mechanisms. more...

Organism:

Escherichia coli; Actinobacillus pleuropneumoniae

Type:

Other

Platforms:

GPL33074 GPL33073

16 Samples

Download data: RDS

(Submitter supplied) Helicobacter pylori genome is rich in restriction - modification (R-M) systems. Around 4 % of the genome codes for components of R-M systems. hpyAVIBM, which codes for a putative phase-variable C5 - cytosine methyltransferase (MTase) from H. pylori lacks a cognate restriction enzyme.

Organism:

Helicobacter pylori; Helicobacter pylori SS1; Helicobacter pylori 26695

Type:

Expression profiling by array

Platform:

GPL13279

12 Samples

Download data: TXT, XLS

(Submitter supplied) Comprehensive analysis of microRNA expression were performed with 238 rat genes of microRNA between CagA-expressing and -non-expressing cells. CagA expression was controlled by tetracycline-off system in RGM1 cells.

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL13427

2 Samples

Download data: TXT

(Submitter supplied) The human gastric pathogen Helicobacter pylori is extremely well adapted to the highly acidic conditions encountered in the stomach. The pronounced acid resistance of H. pylori relies mainly on the ammonia-producing enzyme urease, however, urease-independent mechanisms are likely to contribute to acid adaptation. Acid-responsive gene regulation is mediated at least in part by the ArsRS two-component system consisting of the essential OmpR-like response regulator ArsR and the non-essential cognate histidine kinase ArsS whose autophosphorylation is triggered in response to low pH. more...

Organism:

Helicobacter pylori

Type:

Expression profiling by array

Platform:

GPL3476

4 Samples

Download data

(Submitter supplied) Helicobacter pylori is a human gastric pathogen associated with gastric and duodenal ulcers as well as specific gastric cancers. It is well-evidenced that motility is essential for this pathogen to colonize human gastric tissues. We found that the H. pylori G27 HP0518 mutant showed greater motility than the parental strain, leading to increased cell adhesion and subsequent CagA translocation and NF-κB activation in AGS cells. more...

Organism:

Helicobacter pylori

Type:

Expression profiling by array

Platform:

GPL3476

2 Samples

Download data: CSV, TIFF, TXT, XML

(Submitter supplied) Comparison of RNA expression profiles from NTHi strain R2866 expressing methyltransferase ModA10 (ON) or not (LOCK_OFF).

Organism:

Haemophilus influenzae R2866

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26504

6 Samples

Download data: TXT

(Submitter supplied) Comparison of RNA expression profiles from NTHi strain 723 strains expressing methyltransferase ModA2 (ON) or not (OFF)

Organism:

Haemophilus influenzae

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19560

6 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of N. gonorrhoeae comparing wild type cells to cells with inactivated by kanamycin cassette (km) gene involved in restriction modification NgoAXP or with chloramphenicol cassette (cm) gene involved in restriction-modification NgoAV. The Goal was to study the role of M.NgoAXP and NgoAV methyltransferases in overall expression profile.

Organism:

Neisseria gonorrhoeae

Type:

Expression profiling by array

Platform:

GPL19073

8 Samples

Download data: TXT