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Links from GEO DataSets

Items: 20

1.

Gene expression analysis of cardiac left-ventricle tissue from hybrid mice harboring the Scn5a-1798insD/+ mutation

(Submitter supplied) Prolonged electrocardiographic indices reflecting myocardial impulse conduction and repolarization are risk factors for sudden cardiac death and drug-induced arrhythmia. The PR-interval, QRS-duration and QT-interval are heritable traits influenced by multiple genetic and environmental factors. The genetic underpinnings of these traits are still largely unknown. In this study, we leveraged the variability in cardiac gene expression and the variation in PR-, QRS- and QT-intervals among F2 mice harboring the cardiac sodium ion-channel mutation Scn5a-1798insD/+ derived from the 129P2-Scn5a1798insD/+ and FVB/NJ-Scn5a1798insD/+ cross, to isolate novel genes and biological pathways impacting on cardiac conduction and repolarization.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
120 Samples
Download data: TXT
Series
Accession:
GSE27236
ID:
200027236
2.

Genetic background effect on Scn5a mutant cardiac right ventricle gene expression

(Submitter supplied) Conduction slowing of the electric impulse that drives the heartbeat may evoke lethal cardiac arrhythmias. Mutations in SCN5A, which encodes the pore-forming cardiac sodium channel alpha subunit, are associated with familial arrhythmia syndromes based on conduction slowing. However, disease severity among mutation carriers is highly variable. We hypothesized that genetic modifiers underlie the variability in conduction slowing and disease severity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2995
12 Samples
Download data: TXT
Series
Accession:
GSE19741
ID:
200019741
3.

Athero-susceptibility of inbred mouse strains

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL16570 GPL17400
20 Samples
Download data: CEL, CHP
Series
Accession:
GSE53006
ID:
200053006
4.

Expression data from the aorta of DBA, B6 and 129 mice

(Submitter supplied) Strain differences influence susceptibility to atherosclerosis. Apolipoprotein E-null mice on a DBA/2J genetic background (DBA-apoE) and C57BL/6 (B6-apoe) are highly susceptible to atherosclerosis in the aortic root area compared with those on a 129S6/SvEvTac background (129-apoE). To explore strain-specific differences affecting the susceptibility to atherosclerosis, we performed microarray analysis of aortic arch and root from wild type mice of each strains.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE52818
ID:
200052818
5.

Expression data from thioglycollate-elicited peritoneal macrophages from 129S6/SvEvTac and C57BL/6 mice

(Submitter supplied) Strain differences influence susceptibility to atherosclerosis. Apolipoprotein E-null mice on a C57BL/6 genetic background (B6-apoE) are highly susceptible to atherosclerosis in the aortic root area compared with those on a 129S6/SvEvTac background (129-apoE). To explore strain-specific differences affecting the susceptibility to atherosclerosis, we performed microarray analysis of macrophages from wild type mice of each strains.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE52816
ID:
200052816
6.

Expression data from thioglycollate-elicited peritoneal macrophages from 129S6/SvEvTac and DBA2/J mice

(Submitter supplied) Strain differences influence susceptibility to atherosclerosis. Apolipoprotein E-null mice on a DBA/2J genetic background (DBA-apoE) are highly susceptible to atherosclerosis in the aortic root area compared with those on a 129S6/SvEvTac background (129-apoE). To explore strain-specific differences affecting the susceptibility to atherosclerosis, we performed microarray analysis of macrophages from wild type mice of each strains.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE52473
ID:
200052473
7.

Coxsackievirus B3 (CVB3) infection of AJ, B10.A, CSS3 and B6.chr3AJ (heart tissue day 4)

(Submitter supplied) The pathogenesis of viral myocarditis is a multifactorial process involving host genetics, viral genetics and the environment in which they interact. Here, we used a model of infection with Coxsackievirus B3 to characterize the contribution of host genetics to viral myocarditis. We determined heart CVB3 load in mice from a classical intercross between progenitors A/J (H2a) and B10.A-H2a (B10.A) of different genetic backgrounds but with a common H2 haplotype. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
24 Samples
Download data: TXT
Series
Accession:
GSE19496
ID:
200019496
8.

Blood and Adipose tissue samples

(Submitter supplied) We analyzed the expression of 23,720 transcripts in the adipose tissue of 701 individuals and the blood of 1021 individuals. Keywords: microarray profiling, genetics, gene expression
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL3991
1722 Samples
Download data
Series
Accession:
GSE7965
ID:
200007965
9.

eQTL study of bone marrow derived macrophages and endothelial cells from DBA2xAKR F2 mice

(Submitter supplied) An eQTL analysis between DBA/2J and AKR/J mice strains on the ApoE null background was done in bone marrow derived macrophages and endothelial cells to identify modifier genes that affect atherosclerosis susceptibility.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
218 Samples
Download data: TXT
Series
Accession:
GSE35676
ID:
200035676
10.

Expression Profiling of DA, COP, and F1(COPxDA) rat left ventricles

(Submitter supplied) We used high density oligonucleotide arrays to measure the relative expression levels of ~27,000 probe sets in the left ventricles of inbred rat strains; DA (high performing), Copenhagen (COP, low performing), as well as F1(COPxDA) rats bred from these two strains whose performance was intermediate relative to both parental strains. DA and COP rats differ for both intrinsic aerobic running capacity (assessed with a treadmill exercise test to exhaustion) and intrinsic cardiac performance (as assessed by the Langendorff-Neeley working heart model). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS778 GDS779 GDS780
Platforms:
GPL86 GPL87 GPL85
36 Samples
Download data
Series
Accession:
GSE1795
ID:
200001795
11.
Full record GDS780

Aerobic running capacity: expression profiling of heart ventricles from various strains (RG-U34C)

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 strain sets
Platform:
GPL87
Series:
GSE1795
12 Samples
Download data
DataSet
Accession:
GDS780
ID:
780
12.
Full record GDS779

Aerobic running capacity: expression profiling of heart ventricles from various strains (RG-U34B)

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 strain sets
Platform:
GPL86
Series:
GSE1795
12 Samples
Download data
DataSet
Accession:
GDS779
ID:
779
13.
Full record GDS778

Aerobic running capacity: expression profiling of heart ventricles from various strains (RG-U34A)

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 strain sets
Platform:
GPL85
Series:
GSE1795
12 Samples
Download data
DataSet
Accession:
GDS778
ID:
778
14.

Mapping of a QTL for airway hyperresponsiveness on mouse chromosome 12

(Submitter supplied) The BcA86 strain is a unique recombinant congenic strain created from parental strains A/J and C57BL/6J. Naive mice from the BcA86 strain have a lung responsiveness phenotype resembling mice from airway hyperresponsive strain A/J. However, majority of the BcA86 genome is from the hyporesponsive strain C57BL/6J. Our goal was to identify the genomic regions that are associated with this BcA86 phenotype. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
9 Samples
Download data: CEL
Series
Accession:
GSE52356
ID:
200052356
15.

Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; SNP genotyping by SNP array
Platforms:
GPL10558 GPL13135
258 Samples
Download data
Series
Accession:
GSE55232
ID:
200055232
16.

Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart: gene expression

(Submitter supplied) In recent years genome-wide association studies (GWAS) have uncovered numerous chromosomal loci associated with various electrocardiographic traits and cardiac arrhythmia predisposition. A considerable fraction of these loci lie within inter-genic regions. Trait-associated SNPs located in putative regulatory regions likely exert their effect by modulating gene expression. Hence, the key to unraveling the molecular mechanisms underlying cardiac traits is to interrogate variants for association with differential transcript abundance by expression quantitative trait locus (eQTL) analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
129 Samples
Download data: TXT
Series
Accession:
GSE55231
ID:
200055231
17.

Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart: genotyping

(Submitter supplied) In recent years genome-wide association studies (GWAS) have uncovered numerous chromosomal loci associated with various electrocardiographic traits and cardiac arrhythmia predisposition. A considerable fraction of these loci lie within inter-genic regions. Trait-associated SNPs located in putative regulatory regions likely exert their effect by modulating gene expression. Hence, the key to unraveling the molecular mechanisms underlying cardiac traits is to interrogate variants for association with differential transcript abundance by expression quantitative trait locus (eQTL) analysis. more...
Organism:
Homo sapiens
Type:
SNP genotyping by SNP array
Platform:
GPL13135
129 Samples
Download data: TXT
Series
Accession:
GSE55230
ID:
200055230
18.

Expression data from mouse bone marrow macrophages from a strain intercross

(Submitter supplied) Bone marrow macrophages were cultured from 16 week old apoE-deficient F2 mice from an AKRxDBA/2 intercross Gene expression profiling was performed using Affy 430v2 arrays, and 1967 informative SNP markers were genotyped for each mouse Supplementary file of SNP data attached below from ParAllele 5K mouse linkage panel Keywords: Genetic-genomic
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
207 Samples
Download data: CEL, TXT
Series
Accession:
GSE8512
ID:
200008512
19.

Identification of active gene regulatory elements in the human and murine TBX3 locus

(Submitter supplied) The human and murine TBX3 locus harbors hundreds of active regulatory elements responding to Smad-/Gata- and Tcf-transcription factors in vitro.
Organism:
Mus musculus; Homo sapiens
Type:
Other
Platforms:
GPL16417 GPL15520
19 Samples
Download data: BED, BIGWIG
20.

Tbx3 governs a transcriptional program to maintain atrioventricular conduction system form and function

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL21103
13 Samples
Download data: BED
Series
Accession:
GSE121465
ID:
200121465
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