Similar studies for GEO DataSets (Select 200028117) - GEO DataSets

Select item 2000281171.

IL-4 mediated gene expression profiles in vascular endothelial cells

(Submitter supplied) Endothelial cell activation and dysfunction underlie many vascular disorders, including atherosclerosis and inflammation. Here, we show that interleukin (IL)-4 markedly induced vascular cell adhesion molecule (VCAM)-1, both in cultured endothelial cells and in the intact endothelium in mice. Combined treatment with IL-4 and tumor necrosis factor (TNF)- alpha resulted in further, sustained induction of VCAM-1 expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
13 Samples

Download data: CEL

Series

Accession:: GSE28117

ID:: 200028117

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001008892.

Extensive overlap of the STAT6 and RXR cistromes in the active enhancer repertoire of human CD14+ monocyte-derived differentiating macrophages

(Submitter supplied) Macrophages are able to differentiate into classically polarized (M1) or alternatively polarized (M2) states upon encountering pro-inflammatory cytokines such as interferon (IFN) g or anti-inflammatory cytokines such as interleukin (IL) -4/IL-13, respectively. Moreover, macrophages are known to regulate lipid metabolism via multiple members of the nuclear hormone receptor family, including the retinoid X receptors (RXR). more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL16791
18 Samples

Download data: TXT

Series

Accession:: GSE100889

ID:: 200100889

PubMed Similar studies SRA Run Selector

Select item 2000716443.

The IL4-STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: synthetic construct; Mus musculus; Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL6246 GPL8786
21 Samples

Download data: CEL, CHP

Series

Accession:: GSE71644

ID:: 200071644

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000716424.

Negative control and mir-342-3p mimics-transfected RAW264.7 mouse macrophages.

(Submitter supplied) RAW264.7 mouse macrophages were transfected with negative control and miR-342-3p mimics and subjected to microarray analysis 18 hours after the transfection. We used microarray to obtain global mRNA expression data of negative control and miR-342-3p mimics-transfected RAW264.7 cells.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE71642

ID:: 200071642

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000716415.

Human periheral blood-derived monocytes and unstimulated as well as IL-4-stimulated differentiating macrophages

(Submitter supplied) CD14+ monocytes were separated from human peripheral blood and exposed to IL-4 for 12 or 72 hours then subjected to microarray analysis We used Affymetrix miRNA1.0 microarray to obtain global miRNA expression data of human monocytes, unstimulated and IL-4-stimulated differentiating macrophages.

Organism:: Homo sapiens; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL8786
15 Samples

Download data: CEL, CSV

Series

Accession:: GSE71641

ID:: 200071641

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000250886.

PPARg and IL-4-induced gene expression data from wild-type and STAT6 knockout mouse bone marrow-derived macrophages

(Submitter supplied) C57Bl/6 wild-type and STAT6 KO mice were used to study PPARg and IL-4 signaling. Bone marrow of 3 mice per group was isolated and differentiated to macrophages with M-CSF (20 ng/ml). 20 ng/ml IL-4 was used to induce alternative macrophage activation and 1 uM Rosiglitazone (RSG) was used to activate PPARg. From each mouse 4 samples were generated: 1. M-CSF, 2. M-CSF+RSG, 3. IL-4 and 4. IL-4+RSG. All compounds were added throughout the whole differentiation process, and frech media was added every other day. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
24 Samples

Download data: CEL

Series

Accession:: GSE25088

ID:: 200025088

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001067067.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
141 Samples

Download data: TSV

Series

Accession:: GSE106706

ID:: 200106706

PubMed Full text in PMC Similar studies

Select item 2001067058.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [ChIP-Seq II]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TSV

Series

Accession:: GSE106705

ID:: 200106705

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001067049.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [RNA-Seq II]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
53 Samples

Download data: TSV

Series

Accession:: GSE106704

ID:: 200106704

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010670310.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [GRO-Seq]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: TSV

Series

Accession:: GSE106703

ID:: 200106703

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010670211.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [ATAC-Seq]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: TSV

Series

Accession:: GSE106702

ID:: 200106702

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010670112.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [ChIP-Seq I]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
64 Samples

Download data: TSV

Series

Accession:: GSE106701

ID:: 200106701

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010670013.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [RNA-Seq I]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TSV

Series

Accession:: GSE106700

ID:: 200106700

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20020965414.

Effect of Caspase1 deletion on oxygen-induced retinopathy in C57BL/6 mice

(Submitter supplied) To investigate the expression profile of genes involved in oxygen-induced retinopathy (OIR) and the effect of caspase1 deletion on those genes in retina.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: TXT

Series

Accession:: GSE209654

ID:: 200209654

PubMed Full text in PMC Similar studies

Select item 20006005115.

NF-kB coordinates rapid, BRD4-dependent remodeling of proinflammatory super-enhancers [Chem-Seq]

(Submitter supplied) Proinflammatory stimuli rapidly and globally remodel chromatin landscape, thereby enabling transcriptional responses. Yet, the mechanisms coupling chromatin regulators to the master regulatory inflammatory transcription factor NF-kB remain poorly understood. We report in human endothelial cells (ECs) that activated NF-kB binds to enhancers, provoking a rapid, global redistribution of BRD4 preferentially at super-enhancers, large enhancer domains highly bound by chromatin regulators. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL11154
3 Samples

Download data: WIG

Series

Accession:: GSE60051

ID:: 200060051

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005400016.

NF-kB coordinates rapid, BRD4-dependent remodeling of proinflammatory super-enhancers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL11154 GPL16043
36 Samples

Download data: CEL, WIG

Series

Accession:: GSE54000

ID:: 200054000

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005399917.

NF-kB coordinates rapid, BRD4-dependent remodeling of proinflammatory super-enhancers [Affymetrix]

(Submitter supplied) Proinflammatory stimuli rapidly and globally remodel chromatin landscape, thereby enabling transcriptional responses. Yet, the mechanisms coupling chromatin regulators to the master regulatory inflammatory transcription factor NF-kB remain poorly understood. We report in human endothelial cells (ECs) that activated NF-kB binds to enhancers, provoking a rapid, global redistribution of BRD4 preferentially at super-enhancers, large enhancer domains highly bound by chromatin regulators. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16043
12 Samples

Download data: CEL

Series

Accession:: GSE53999

ID:: 200053999

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005399818.

NF-kB coordinates rapid, BRD4-dependent remodeling of proinflammatory super-enhancers [ChIP-Seq]

(Submitter supplied) Proinflammatory stimuli rapidly and globally remodel chromatin landscape, thereby enabling transcriptional responses. Yet, the mechanisms coupling chromatin regulators to the master regulatory inflammatory transcription factor NF-kB remain poorly understood. We report in human endothelial cells (ECs) that activated NF-kB binds to enhancers, provoking a rapid, global redistribution of BRD4 preferentially at super-enhancers, large enhancer domains highly bound by chromatin regulators. more...