GEO DataSets

(Submitter supplied) The objective of this study was to identify genes that are differentially regulated in cultured sympathetic neurons during BMP-induced dendritic growth and to determine the temporal expression patterns of these genes.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3930

Platform:

GPL85

9 Samples

Download data: CEL

Analysis of superior cervical ganglia (SCG) cultured neurons treated with bone morphogenic protein-7 (BMP-7) for 6 or 24h. Addition of BMPs triggers these neurons to extend multiple dendrites. Results provide insight into molecular mechanisms underlying initial formation of primary dendrites.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 2 time sets

Platform:

GPL85

Series:

GSE28150

9 Samples

Download data: CEL

(Submitter supplied) MicroRNA profiling of cultured sympathetic neurons from the superior cervical ganglia of E21 Sprague-Dawley rat pups following growth under control conditions or after treatment with BMP-7 at 50 ng/mL for 6 hours or 24 hours.

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL20108

6 Samples

Download data: TXT, XLS

(Submitter supplied) Class I and IV Drosophila dendritic arborization sensory neurons were isolated via magnetic bead sorting and total RNA isolated from the samples was used for gene expression profiling. Elucidating the molecular mechanisms controlling dendrite development is key to understanding the pivotal role these structures play in influencing synaptic integration and neural function. Despite significant advances in this field, genetic pleiotropy remains a significant impediment to investigating such complex developmental processes. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL7300

7 Samples

Download data: TXT

(Submitter supplied) Elucidating the molecular mechanisms controlling dendrite development is key to understanding the pivotal role these structures play in influencing synaptic integration and neural function. Despite significant advances in this field, genetic pleiotropy remains a significant impediment to investigating such complex developmental processes. To circumvent this problem, we have applied class specific neuron transcriptional expression profiling coupled to an in vivo RNAi functional validation screen in order to dissect the molecular bases of Drosophila class IV dendritic arborization (da) neuron dendritogenesis. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL6385

2 Samples

Download data: TXT

(Submitter supplied) We identified 112 known genes and 150 expressed sequence tags (ESTs) showing more than a 1.3 fold change in target-exposed neurons compared to neurons grown in the absence of target. Expression of 36 genes and 49 ESTs was upregulated, while expression of 76 genes and 101 ESTs was downregulated by the presence of target during the culture period. Overall, these changes represented approximately 1.6% of the probe set. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

2 Samples

Download data: CEL

(Submitter supplied) The transcription factor Egr3 has been shown to have a cell autonomous role in sympathetic nervous system (SNS) development. We utilized microarray analysis to identify potential downstream target genes deregulated with loss of Egr3. Both conditions were in the null Bax background to prevent apoptosis and therefore mitigate identification of apoptosis related genes. Our analysis identified genes involved in biological processes that were expected such as SNS development and axonogenesis as well as those that were unexpected such as dendritogenesis and axon guidance. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6105

6 Samples

Download data: TXT

(Submitter supplied) Gene expression profiles of Ngn3-overexpressing cultured hippocampal neurons was compared to the profile of the corresponding control populations. (neurons expressing GFP). Neurogenin3, a proneural transcription factor controlled by Notch receptor, is involved in hippocampal neuron differentiation and synapses, but little is known about the molecular bases of Ngn3 activity in neurons. Microarray analysis indicated that overexpression of Ngn3 upregulated a number of genes related with cytoskeleton dynamics. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8063

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

60 Samples

Download data: TXT

(Submitter supplied) Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily of growth factors. They are known for their roles in regulation of osteogenesis and developmental processes and, in recent years, evidence has accumulated of their crucial functions in tumor biology. BMP7, in particular, has been implicated in breast cancer. However, little is known about BMP target genes in the context of tumor. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

30 Samples

Download data: TXT

(Submitter supplied) Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily of growth factors. They are known for their roles in regulation of osteogenesis and developmental processes and, in recent years, evidence has accumulated of their crucial functions in tumor biology. BMP4, in particular, has been implicated in breast cancer. However, little is known about BMP target genes in the context of tumor. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

30 Samples

Download data: TXT

(Submitter supplied) Analysis of BMP-2 induced gene expression of C2C12 cells treated with the endocytosis inhibitor dynasore to identify gene expression profiles which are sensitive to endocytosis inhibition. Our data highlight the importance of endocytosis for transmission of an extracellular BMP-2 signal into the nucleus to activate a transcriptional gene network

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

8 Samples

Download data: TXT