GEO DataSets

(Submitter supplied) Analyzing culture supernatants of yeast and hyphal cells of Candida albicans by mass spectrometry, we found two close homologues of pathogenesis-related (PR-) 1 proteins, Rbe1p and Rbt4p, in the secretome of this human pathogen. By sequence homology, we assigned three yet not characterized open reading frames, ORF19.6200, ORF19.2787 and ORF19.2336, in addition to Rbe1p and Rbt4p to a novel family of proteins. more...

Organism:

Candida albicans SC5314; Candida albicans

Type:

Expression profiling by array

Platform:

GPL10374

12 Samples

Download data: GPR

(Submitter supplied) Invasion of host tissue by the human fungal pathogen, Candida albicans is an important step during many forms of candidosis. However, not all C. albicans strains possess the same invasive and virulence properties. It is known for example that the two clinical isolates SC5314 and ATCC10231 differ in their ability to invade into host tissue and to cause infections. Strain SC5314 is invasive whereas strain ATCC10231 is non-invasive and strongly attenuated in virulence as compared to SC5314. more...

Organism:

Candida albicans

Type:

Genome variation profiling by array

Platform:

GPL6453

2 Samples

Download data: GPR

(Submitter supplied) Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. albicans gene arrays were used for comparative analysis of global gene expression in the two species in reconstituted human oral epithelium (RHE). C. albicans (SC5314) showed upregulation of hypha-specific and virulence genes within 30 min postinoculation, coinciding with rapid induction of filamentation and increased RHE damage. more...

Organism:

Candida dubliniensis; Candida albicans

Type:

Expression profiling by array

Platform:

GPL6453

8 Samples

Download data: GPR, TXT

(Submitter supplied) Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. albicans gene arrays were used for comparative analysis of global gene expression in the two species in reconstituted human oral epithelium (RHE). C. albicans (SC5314) showed upregulation of hypha-specific and virulence genes within 30 min postinoculation, coinciding with rapid induction of filamentation and increased RHE damage. more...

Organism:

Candida albicans; Candida dubliniensis

Type:

Expression profiling by array

Platform:

GPL6475

6 Samples

Download data: GPR, TXT

(Submitter supplied) We report that a transcriptional regulator that originated in the lineage that gave rise to multiple host-associated Candida species is a key component of the circuitry that governs the C. albicans cell surface composition. Specifically, we show that the transcription regulator ZCF21 controls the expression of genes encoding multiple cell surface proteins and cell wall modifying enzymes.

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19036

8 Samples

Download data: FASTA, WIG

(Submitter supplied) 70mer oligonucleotides representing 6,346 of the 6,354 predicted ORFs in the annotated C. albicans genome assembly 19 were designed using an ArrayOligoSelector and were manufactured by and obtained from Illumina (San Diego, CA). One genome equivalent of each ORF was spotted three times per slide (i.e., n = 3 for each hybridization).

Organism:

Candida albicans

4 Series

20 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL22403 GPL26840

16 Samples

Download data: TXT

(Submitter supplied) Candida albicans is an opportunistic pathogen which is responsible for widespread nosocomial infections. It encompasses a fungus specific serine/threonine protein phosphatase gene CaPPZ1 that is involved in cation transport, cell wall integrity, oxidative stress response, morphological alterations, and virulence. We demonstrated that tert-butyl-hydoperoxide induced oxidative stress suppressed the growth rate and blocked the proliferation of the fungal cells without effecting their viability, both in the cappz1 KO mutant and in the genetically matching QMY23 control strains. more...

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22403

12 Samples

Download data: XLSX

(Submitter supplied) Candida albicans is an opportunistic pathogen which is responsible for widespread nosocomial infections. It encompasses a fungus specific serine/threonine protein phosphatase gene CaPPZ1 that is involved in cation transport, cell wall integrity, oxidative stress response, morphological alterations, and virulence. We demonstrated that tert-butyl-hydoperoxide induced oxidative stress suppressed the growth rate and blocked the proliferation of the fungal cells without effecting their viability, both in the cappz1 KO mutant and in the genetically matching QMY23 control strains. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL26840

4 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL16169

12 Samples

Download data: CSV

(Submitter supplied) Transcriptional profiling of Candida cells vs putative MFS transporter QDR2 knockout cells

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL16169

3 Samples

Download data: CSV, TXT

(Submitter supplied) Transcriptional profiling of Candida cells vs putative MFS transporter QDR1 knockout cells

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL16169

3 Samples

Download data: CSV, TXT

(Submitter supplied) Transcriptional profiling of Candida cells vs putative MFS transporter QDR2 knockout cells

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL16169

3 Samples

Download data: CSV, TXT

(Submitter supplied) Transcriptional profiling of Candida cells vs putative MFS transporter QDR1 knockout cells

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL16169

3 Samples

Download data: CSV, TXT

(Submitter supplied) Cap1p, a transcription factor of the basic region-leucine zipper family, regulates oxidative stress response (OSR) in Candida albicans. Alteration of its C-terminal cysteine-rich domain (CRD) results in Cap1p nuclear retention and transcriptional activation. To better understand the function of Cap1p in C. albicans, we used genome-wide location profiling (ChIP-on-chip) to identify its transcriptional targets in vivo. more...

Organism:

Candida albicans

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL4037

6 Samples

Download data: PAIR

(Submitter supplied) Cap1p, a transcription factor of the basic region-leucine zipper family, controls the oxidative stress response in Candida albicans. It was shown that alteration of the C-terminal cysteine-rich domain (CRD) of Cap1p results in nuclear retention and constitutive transcriptional activation. To further characterize the function of Cap1p in C. albicans, we used genome-wide location profiling (ChIP-on-chip), allowing the identification of Cap1p-transcriptional targets in vivo. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platforms:

GPL6808 GPL5723

18 Samples

Download data: CEL

(Submitter supplied) Candida albicans is an opportunistic pathogenic fungus that is able to assume several morphologies, including yeast and hyphal growth forms. The hyphal morphology can be induced by various environmental stimuli and is accompanied by expression of a large set of hyphal-specific genes (HSGs). Cell cycle and morphogenetic programs are interconnected: notably, inhibition of cell cycle progression often causes a switch to filamentous growth. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL6808

4 Samples

Download data: CEL, CHP

(Submitter supplied) The Candida albicans delta-doa1 mutant was investigated. This mutant shows lots of phenotypes. Doa1 protein has several WD 40 repeats. Keywords: mutant versus wildtype, comparative expression analysis

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL4751

3 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:

GPL19036

10 Samples

Download data

(Submitter supplied) Candida albicans is associated with humans as both a harmless commensal organism and a pathogen. Cph2 is a transcription factor whose DNA binding domain is similar to mammalian sterol response element binding proteins (SREBPs). SREBPs are master regulators of cellular cholesterol levels, and are highly conserved from fungi to mammals. However, ergosterol biosynthesis is regulated by the zinc finger transcription factor Upc2 in C. more...

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19036

4 Samples

Download data: TXT