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Links from GEO DataSets

Items: 19

1.

Expression analysis of mouse retinas after treatment with VEGF-A or Dll4-Fc.

(Submitter supplied) Transcriptional profiling of retinas extracted from mouse pups 24 hours after IVT injection (at P8) of 1 microgram VEGFA, 4 micrograms Dll4-Fc, or 4 microgram hFc alone. Goal was to determine the mechanism by which inhibiting Dll4/Notch pathway is vasoprotective during retinal development.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13397
16 Samples
Download data: TXT
Series
Accession:
GSE28516
ID:
200028516
2.

Expression profiling after ICAP1 or constitutive active NOTCH1 over expression in human umbilical vein endothelial cells

(Submitter supplied) ICAP1 (also known as ITG1BP1) is a protein interaction partner of beta1-integrins and the cerebral cavernous malformation protein 1 (CCM1, also known as KRIT1). In mice Icap1 plays an important role for bone development. The function of ICAP1 in endothelial cells is poorly understood. However, the interactions with beta1-integrins and CCM1 suggest that ICAP1 should play an important role also in endothelial cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
6 Samples
Download data: TXT
Series
Accession:
GSE18035
ID:
200018035
3.

Gene expression analysis of Rip1Tag2 spontaneous tumors treated by sEphB4-Alb or PBS

(Submitter supplied) Rip1Tag2 mice spontaneously develop tumors. Mice were treated with sEphB4-Alb or PBS for 3.5 weeks. RNA was isolated from harvested tumors and subjected to global gene expression analysis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11033
4 Samples
Download data: TXT
Series
Accession:
GSE24603
ID:
200024603
4.

Response of C2C12-hN1∆ECD to DAPT washout

(Submitter supplied) C2C12 cells expressing constitutively active hN1∆ECD were activated by complete DAPT washout for 1h or 6h, or left in 10 uM DAPT
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
3 Samples
Download data: XLSX
Series
Accession:
GSE72847
ID:
200072847
5.

Gene expression profiles of control IgG and anti-Dll4 Ab treated retinal endothelial cells (ECs) in EC-specific RiboTag mouse (Cdh5-CreERT2 Rpl22 tm1.1Psam)

(Submitter supplied) We report the gene expression profiles of control IgG and anti-Dll4 Ab treated retinal endothelial cells (ECs) in EC-specific RiboTag mouse (Cdh5-CreERT2 Rpl22 tm1.1Psam )
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
7 Samples
Download data: TSV
Series
Accession:
GSE142671
ID:
200142671
6.

Expression data from WT and Snail1 knockout (KO) embryonic endothelial cells (ECs)

(Submitter supplied) Snail1 is a master factor of epithelial to mesenchymal transitioin (EMT), however, its role in embryonic vascular development is largely undefined. We used microarrays to compare the global programme of gene expression between cultured WT and Snai1 KO embyronic ECs.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
2 Samples
Download data: CEL
Series
Accession:
GSE57030
ID:
200057030
7.

Sequential ligand-dependent Notch signaling activation regulates valve primordium formation and morphogenesis

(Submitter supplied) Our studies identify a mechanism of signaling crosstalk during valve morphogenesis that sheds light on the origin of congenital heart defects associated with reduced Notch function.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11002
16 Samples
Download data: TXT
Series
Accession:
GSE74556
ID:
200074556
8.

Molecular mechanism underline immune cell type population shift upon anti-DLL4 treatment

(Submitter supplied) Molecular mechanism underline immune cell type population shift upon anti-DLL4 treatment
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10964
18 Samples
Download data: TXT
Series
Accession:
GSE24296
ID:
200024296
9.

Hypoxia-induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling

(Submitter supplied) Hypoxia (low oxygen) and Notch signaling are two important regulators of vascular development, but how they interact in controlling the choice between arterial and venous fates for endothelial cells during vasculogenesis is less well understood. In this report, we show that hypoxia and Notch signaling intersect in promotion of arterial differentiation. Hypoxia upregulated expression of the Notch ligand Dll4 and increases Notch signaling, in a process requiring the vasoactive hormone adrenomedullin but not endogenous VEGF. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
12 Samples
Download data: TXT
Series
Accession:
GSE35894
ID:
200035894
10.

Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade

(Submitter supplied) Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryonic angiogenesis, but its role in coronary development remains uncertain. We show Jag1, Dll4 and activated Notch1 receptor expression in sinus venosus (SV) endocardium. Endocardial Jag1 removal blocks SV capillary sprouting, while Dll4 inactivation stimulates excessive capillary growth, suggesting that ligand antagonism regulates coronary primary plexus formation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
36 Samples
Download data: XLS
Series
Accession:
GSE110614
ID:
200110614
11.

Expression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs

(Submitter supplied) LRF, which is encoded by the ZBTB7A gene and formerly known as POKEMON (POK erythroid myeloid ontogenic factor), was originally identified as a PLZF (promyelocytic leukemia zinc finger) homologue interacting with BCL6 (B-cell lymphoma 6). LRF is a transcription factor that is broadly expressed in hematopoietic lineage cells, but its expression is particularly high in erythroblasts and germinal center (GC) B-cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
5 Samples
Download data: CEL
Series
Accession:
GSE41839
ID:
200041839
12.

Single-cell RNA-sequencing of CD45+ cells isolated from mouse dura mater or brain after photothrombotic injury

(Submitter supplied) To further elucidate molecular differences in immune cells and identify potential sources of Vegfa in response to photothrombotic injury, we performed single-cell RNA-sequencing of CD45+ cells isolated from the mouse dura mater or brain after photothrombotic injury.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
4 Samples
Download data: CSV
Series
Accession:
GSE145973
ID:
200145973
13.

RNA-sequencing of dura mater or brain ECs isolated from 8-week-old mice

(Submitter supplied) To further elucidate fundamental molecular differences between dura mater and brain ECs, we performed RNA-sequencing of primary dura mater or brain ECs isolated from adult mice
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
4 Samples
Download data: TXT
Series
Accession:
GSE138561
ID:
200138561
14.

Notch ligand Dll4 impairs the recruitment of hemogenic cells into intra-aortic clusters and limits hematopoietic stem cell production.

(Submitter supplied) Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium in the embryonic aorta. In most vertebrates, hemogenic cells protrude into the aortic lumen forming clusters where the hematopoietic features are acquired. Although much is known about the molecular characteristics of the hematopoietic cells, we still lack basic understanding on the origin and 3D-organization of intraortic hematopoietic clusters (IAHC) in the mouse embryo and how they evolve over time. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
24 Samples
Download data: TXT
Series
Accession:
GSE124875
ID:
200124875
15.

Notch ligand Dll4 impairs the recruitment of hemogenic cells into intra-aortic clusters and limits hematopoietic stem cell production

(Submitter supplied) Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium in the embryonic aorta. In most vertebrates, hemogenic cells protrude into the aortic lumen forming clusters where the hematopoietic features are acquired. Although much is known about the molecular characteristics of the hematopoietic cells, we still lack basic understanding on the origin and 3D-organization of intraortic hematopoietic clusters (IAHC) in the mouse embryo and how they evolve over time. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
483 Samples
Download data: TXT
Series
Accession:
GSE124477
ID:
200124477
16.

Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis

(Submitter supplied) We asked whether combining Notch and VEGF blockade would enhance suppression of tumor angiogenesis and growth, using the NGP neuroblastoma model. NGP tumors were engineered to express a Notch1 decoy construct (N1D), which restricts Notch signaling, and then treated with either the anti-VEGF antibody bevacizumab or vehicle. Combining Notch and VEGF blockade led to blood vessel regression, increasing endothelial cell apoptosis and disrupting pericyte coverage of endothelial cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
24 Samples
Download data: CEL
Series
Accession:
GSE48880
ID:
200048880
17.

RNAseq of wild type (WT) and Dll4+/- mouse lung

(Submitter supplied) We report the application of RNA sequencing for high-throughput profiling of gene epxression in WT and Dll4 +/- lung
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
10 Samples
Download data: XLSX
Series
Accession:
GSE164732
ID:
200164732
18.

Single cell(sc) RNAseq of wild type (WT) mouse lung

(Submitter supplied) We report the application of scRNA sequencing for high-throughput profiling of gene epxression in 40 unsupervised lung cell clusters
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
3 Samples
Download data: MTX, TSV
Series
Accession:
GSE164621
ID:
200164621
19.

Transcriptome analysis of the role of SMAD6 in mediating endothelial cell response to laminar shear stress by high throughput RNA sequencing

(Submitter supplied) Laminar shear stress regulates blood vessel morphogenesis and subsequent quiescence, but how endothelial cells (EC) enact and maintain the vascular homeostasis required in most vessels for proper vessel function is poorly understood. SMAD6, a scaffold for several signaling pathways, is expressed in developing arteries and its expression is flow-regulated. We found that SMAD6 is essential for endothelial cell flow-mediated responses, and that it functions downstream of the mechanosensor Notch1. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
8 Samples
Download data: XLSX
Series
Accession:
GSE147036
ID:
200147036
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