GEO DataSets

(Submitter supplied) Exposure to nanomaterials (NM) during sensitive stages of development may predispose organisms to diseases later in life. However, direct translocation of NM from mother to fetus through the placenta is limited. The present study tests the hypothesis that pulmonary exposure to NM and NM-induced stress, such as inflammation during gestation, can lead to secondary effects in the growing fetus. Time mated C57BL/6BomTac mice were exposed by intratracheal instillation to vehicle (Milli Q water) or one of three concentrations (2.75, 13.5 or 67 µg/animal) of carbon black Printex 90 (CB) dispersions on gestational days 7, 10, 15 and 18 to a total final dose of 11, 54 or 268 µg/animal. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

20 Samples

Download data: TXT

(Submitter supplied) Exposure to nanomaterials (NM) during sensitive stages of development may predispose organisms to diseases later in life. However, direct translocation of NM from mother to fetus through the placenta is limited. The present study tests the hypothesis that pulmonary exposure to NM and NM-induced stress, such as inflammation during gestation, can lead to secondary effects in the growing fetus. Time mated C57BL/6BomTac mice were exposed by intratracheal instillation to vehicle (Milli Q water) or one of three concentrations (2.75, 13.5 or 67 µg/animal) of carbon black Printex 90 (CB) dispersions on gestational days 7, 10, 15 and 18 to a total final dose of 11, 54 or 268 µg/animal. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

38 Samples

Download data: TXT

(Submitter supplied) Exposure to nanomaterials (NM) during sensitive stages of development may predispose organisms to diseases later in life. However, direct translocation of NM from mother to fetus through the placenta is limited. The present study tests the hypothesis that pulmonary exposure to NM and NM-induced stress, such as inflammation during gestation, can lead to secondary effects in the growing fetus. Time mated C57BL/6BomTac mice were exposed by intratracheal instillation to vehicle (Milli Q water) or one of three concentrations (2.75, 13.5 or 67 µg/animal) of carbon black Printex 90 (CB) dispersions on gestational days 7, 10, 15 and 18 to a total final dose of 11, 54 or 268 µg/animal. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

18 Samples

Download data: TXT

(Submitter supplied) To investigate the effects of administration of carbon black nanoparticle (CB-NP) to pregnant mice on the brain development in infantile mice, we have employed whole-genome microarray expression profiling to identify genes which show dose-dependent differential expression with astrogliosis in the frontal cortex of offspring mice. Some pregnant mice were pretreated with ascorbic acid to investigate the mechanism underlying the CB-NP effect. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

32 Samples

Download data: TXT

(Submitter supplied) In the present study we investigate the effect of maternal pulmonary exposure to titanium dioxide (UV-Titan designed for use in the paint and lacquer industry) on prenatally exposed offspring. Time-mated mice (C57BL/6BomTac) were exposed by inhalation for 1 h/day to 42 mg UV-titan/m3 aerosolized powder or filtered air during gestation days (GD) 8-18. We evaluated levels of DNA strand breaks using the comet assay in bronchioalveolar lavage (BAL) cells and liver cells of the time-mated mice, and in liver cells of the offspring. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

16 Samples

Download data: TXT

(Submitter supplied) Pulmonary exposure to high doses of nanoparticles (NP) leads to well characterized lung toxicity in addition to long-term NP retention. However, pulmonary NP accumulation and toxicity following low dose exposures are not well described. In the present study we sought to: (1) investigate particle retention in mouse lungs following intratracheal instillation of varying doses of nano-sized titanium dioxide (nano-TiO2) and (2) determine the effects of long-term particle accumulation on pulmonary systems. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

65 Samples

Download data: TXT

(Submitter supplied) Exposure to PFOA during gestation altered the expression of genes related to fatty acid catabolism in both the fetal liver and lung. In the fetal liver, the effects of PFOA were robust and also included genes associated with lipid transport, ketogenesis, glucose metabolism, lipoprotein metabolism, cholesterol biosynthesis, steroid metabolism, bile acid biosynthesis, phospholipid metabolism, retinol metabolism, proteosome activation, and inflammation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3410 GDS3411

Platform:

GPL1261

59 Samples

Download data: CEL

Analysis of livers or lungs of fetuses dosed during gestation with up to 3 mg/(kg day) perfluorooctanoic acid (PFOA), an industrial chemical that induces growth deficits and mortality in murine neonates. Results provide insight into the molecular basis of PFOA-induced developmental toxicity.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 dose, 2 tissue sets

Platform:

GPL1261

Series:

GSE13044

29 Samples

Download data: CEL

Analysis of livers or lungs of fetuses dosed during gestation with up to 10 mg/(kg day) perfluorooctanoic acid (PFOA), an industrial chemical that induces growth deficits and mortality in murine neonates. Results provide insight into the molecular basis of PFOA-induced developmental toxicity.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 dose, 2 tissue sets

Platform:

GPL1261

Series:

GSE13044

30 Samples

Download data: CEL

(Submitter supplied) The aim of this study was to investigate the effects of administration of carbon black nanoparticle (CB-NP) to pregnant mice on the development of lymphoid tissues in infantile mice. Pregnant ICR mice were treated with a suspension of CB-NP 95 microg/kg/time) by intranasal instillation, twice, on gestational day 5 and 9. Spleen and thymus were collected from offspring mice at 5 days post-partum.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

4 Samples

Download data: TXT

(Submitter supplied) Adverse lung effects in rodents following pulmonary exposure to multi-walled carbon nanotubes (MWCNT) are well documented. However, systemic effects are less understood. Prospective epidemiological studies have shown increased cardiovascular disease risk after pulmonary exposure to airborne particles, which has led to concerns that inhalation exposure to MWCNT might pose similar risks. We used high-content genomics tools to compare hepatic responses after exposure to a short, entangled MWCNT to the hepatic responses after exposure to a long, stiffer MWCNT at the global transcriptomic level. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

60 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL13493

41 Samples

Download data: TXT

(Submitter supplied) miRNAs were measured in mice exposed to vehicle control (0.9% NaCl MilliQ water containing 10% v/v acellular BAL) or 0.162 mg Printex 90 in vehicle by intratracheal instillation and sacrificed 1, 3 and 28 days after exposure.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL13493

33 Samples

Download data: TXT

(Submitter supplied) miRNAs were measured in pregant mice exposed to vehicle control (nanopure water) or a cumulative dose of 0.268 mg Printex 90 in vehicle by intratracheal instillation and sacrificed at weaning (26-27 days after exposure).

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL13493

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

97 Samples

Download data: TXT

(Submitter supplied) We investigated pulmonary mRNA profiles of female mice exposed to 0.018, 0.054 and 0.162 mg Printex 90 carbon black nanoparticles by single intra-tracheal instillation. We examined responses to these doses 1, 3 and 28 days after exposure, alongside respective controls. This study demonstrates widespread changes in inflammatory and acute phase response genes that persisted to 28 days at the highest exposure dose. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

67 Samples

Download data: TXT

(Submitter supplied) We investigated hepatic mRNA profiles of female mice exposed to 0.162 mg Printex 90 carbon black nanoparticles by single intra-tracheal instillation. We examined responses to this dose 1, 3 and 28 days after exposure, alongside respective controls. We show that genes part of the 3-hydroxy-3-methyl-glutaryl-CoA reductase pathway to be up-regulated by exposure to Printex 90.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

30 Samples

Download data: TXT

(Submitter supplied) Carbon black nanoparticles (CBNP) are the most widely produced nanomaterial and are thus a concern for occupational exposures. CBNPs are known to cause inflammation upon inhalation; however, detailed time course data to evaluate the changing nature of inflammatory responses have not been evaluated. In this study, we investigate the short- and longer-term effects of CBNP following a single intratracheal exposure. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

76 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

44 Samples

Download data: TXT

(Submitter supplied) There is great interest in substituting animal with in vitro experimentation in human health risk assessment, but there are rather few comparisons of in vitro and in vivo biological responses to engineered nanomaterials (ENM). We used high-content genomics tools, to compare in vivo pulmonary responses of multiwalled carbon nanotubes (MWCNT) to those in vitro in cultured lung epithelial cells at the global transcriptomic level. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

22 Samples

Download data: TXT