GEO DataSets

(Submitter supplied) Passive smoke intake by pregnant women may have detrimental effects such as spontaneous abortion, lower birth weight, stillbirth, and reduced infant lung function. To extend our knowledge on molecular effects of tobacco smoke exposure in pregnancy, we analyzed transcriptome alterations in passive smokers (PS) and compared them to those in active smokers (AS). Using Illumina Expression Beadchip with 24,526 transcript probes, gene expression patterns were assayed in placentas from PS (N=25) exposed to environmental tobacco smoke (ETS) throughout pregnancy and non-exposed (NS) counterparts (N=35), and in cord blood cells from their newborns. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6883

104 Samples

Download data: TXT

(Submitter supplied) Smoking in pregnancy increases a woman's risk of preterm delivery resulting in serious health problems during the newborn period, chronic lifelong disabilities (such as cerebral palsy, mental retardation and learning problems), and even death. Further, smoking women have placental problems such as placenta previa (a low-lying placenta that covers part or all of the opening of the uterus), placental abruption (in which the placenta peels away, partially or almost completely before delivery) often resulting in bleeding during delivery. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3793

Platform:

GPL6104

76 Samples

Download data: TXT

Analysis of placentas of women who smoked during pregnancy. Smoking increases the risk of preterm delivery and complications such as placental previa and abruption. Results provide insight into the molecular basis of smoke-induced placental abnormalities.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 dose sets

Platform:

GPL6104

Series:

GSE18044

76 Samples

Download data

(Submitter supplied) Maternal smoking has a severe negative effect on all stages of pregnancy that in consequence impairs fetal growth and development. Tobacco smoke-related defects are well established at the clinical level; however, little is known about molecular mechanisms underlying these pathological conditions. We thus employed a genomic approach to determine transcriptome alterations induced by maternal smoking in pregnancy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3929

Platform:

GPL6883

183 Samples

Download data: TXT

Analysis of peripheral blood leukocytes and placenta of pregnant smokers. Umbilical cord blood leukocytes of their newborns also examined. Maternal smoking has a negative effect on all stages of pregnancy. Results provide insight into molecular mechanisms underlying tobacco smoke-related defects.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 3 specimen sets

Platform:

GPL6883

Series:

GSE27272

183 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

synthetic construct; Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL17400 GPL16384

45 Samples

Download data: CEL

(Submitter supplied) Background: In utero smoke exposure is a recognized risk factor for impaired lung function development and a significant risk factor for airway disease. Despite intensive anti-tobacco campaigns the prevalence of smoking pregnant women has remained high requiring additional strategies to protect the offspring’s lung. To achieve this goal, it is critical to understand the mechanisms how disease risks are established in early life. more...

Organism:

Mus musculus; synthetic construct

Type:

Non-coding RNA profiling by array

Platform:

GPL16384

24 Samples

Download data: CEL

(Submitter supplied) Background: In utero smoke exposure is a recognized risk factor for impaired lung function development and a significant risk factor for airway disease. Despite intensive anti-tobacco campaigns the prevalence of smoking pregnant women has remained high requiring additional strategies to protect the offspring’s lung. To achieve this goal, it is critical to understand the mechanisms how disease risks are established in early life. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17400

21 Samples

Download data: CEL

(Submitter supplied) The objective of this study was to identify the tissue expression patterns and biological pathways enriched in term cord blood fetal RNA of obese women compared to lean In fetuses of obese women, 683 differentially regulated genes were identified.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

16 Samples

Download data: CEL

(Submitter supplied) Microarray analysis to globally assess gene expression at the maternal-fetal interface Keywords: age

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2528 GDS2529

Platforms:

GPL97 GPL96

72 Samples

Download data: CEL

Analysis of the basal plate of the placenta from midgestation to term. The basal plate is the region where maternal and fetal cells coexist. Its proper formation is required for pregnancy. Results provide insight into the molecular basis of the unique cell-cell interactions in the basal plate.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 12 age, 2 development stage sets

Platform:

GPL97

Series:

GSE5999

36 Samples

Download data: CEL

Analysis of the basal plate of the placenta from midgestation to term. The basal plate is the region where maternal and fetal cells coexist. Its proper formation is required for pregnancy. Results provide insight into the molecular basis of the unique cell-cell interactions in the basal plate.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 12 age, 2 development stage sets

Platform:

GPL96

Series:

GSE5999

36 Samples

Download data: CEL

(Submitter supplied) Maternal smoking doubles the risk of delivering a low birth weight infant. The purpose of this study was to analyze differential gene expression in umbilical cord tissue as a function of maternal smoking, with an emphasis on growth-related genes. We recruited 15 pregnant smokers and 15 women who never smoked during pregnancy to participate RNA was isolated from umbilical cord tissue collected and snap frozen at the time of delivery. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

30 Samples

Download data

(Submitter supplied) Anorexia nervosa (AN) is a devastating eating disorder characterized by self-starvation that mainly affects women. Its etiology is unknown, which impedes successful treatment options leading to a limited chance of full recovery. Here, we show that gestation is a vulnerable window that can influence the predisposition to AN. By screening placental microRNA expression of naive and prenatally stressed (PNS) fetuses and assessing vulnerability to activity-based anorexia (ABA) in early adulthood, we identify miR-340 as a sexually dimorphic regulator involved in prenatal programming of ABA. more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL24611

8 Samples

Download data: TXT

(Submitter supplied) We are investigating the transcriptional response of newborns in response to prenatal arsenic exposure We used microarrays to detail the global programme of gene expression response due to prenatal arsenic exposure Keywords: dose (arsenic)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

64 Samples

Download data: CEL