GEO DataSets

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

10 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL6947 GPL6101

80 Samples

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(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

10 Samples

Download data: TXT

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

10 Samples

Download data: TXT

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

10 Samples

Download data: TXT

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

20 Samples

Download data: TXT

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

20 Samples

Download data: TXT

(Submitter supplied) Non-invasive or minimally invasive surrogate approaches to detect/predict target organ toxicity have significant practical applications in occupational toxicology. Presently, using a rat model, we have investigated the potential application of peripheral blood transcriptomics as a practical approach to study the mechanisms of silica-induced pulmonary toxicity. Rats were exposed by inhalation to crystalline silica for one week (15 mg/m3, 6-hours/day, 5 days/week). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

24 Samples

Download data: TXT

(Submitter supplied) Occupational exposure to crystalline silica results in serious health effects, most notably, silicosis and cancer. A proper understanding of the mechanism(s) underlying the initiation and progression of silica-induced pulmonary toxicity is critical for the intervention and/or prevention of the adverse health effects associated with crystalline silica exposure. Rats were exposed to crystalline silica by inhalation at a concentration of 15 mg/m3, 6 hours/day, 5 days/week for 3, 6 or 12 weeks. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

36 Samples

Download data: TXT

(Submitter supplied) The capability to detect target organ toxicity as well as to determine the molecular mechanisms underlying such toxicity by employing surrogate biospecimens that can be obtained by a non-invasive or minimally invasive procedure has significant advantage in occupational toxicology. Pulmonary toxicity and global gene expression profile in the lungs, peripheral blood and bronchoalveolar lavage (BAL) cells were determined in rats at 44-weeks following pulmonary exposure to crystalline silica (15 mg/m3, 6-hours/day, 5 days). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

36 Samples

Download data: TXT

(Submitter supplied) Identification of molecular target(s) and mechanism(s) of silica-induced pulmonary toxicity is important for the intervention and/or prevention of diseases associated with occupational exposure to crystalline silica. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 h/day, 5 days) and global gene expression profile was determined in the lungs by microarray analysis at 1, 2, 4, 8, and 16 weeks following termination of silica exposure. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

60 Samples

Download data: TXT

(Submitter supplied) The present research aimed to investigate peripheral blood gene expression profiling as a minimally invasive surrogate approach to study silica-induced pulmonary toxicity. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 hours/day, 5 days). Pulmonary damage and blood gene expression profiles were determined at various latency periods (0 - 16 weeks). Silica exposure resulted in pulmonary toxicity and this was evidenced by histological changes in the lungs and elevation of LDH activity, and total protein and albumin contents in the bronchoalveolar lavage fluid (BALF) of the rats. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS5197 GDS5198 GDS5199

Platform:

GPL6101

96 Samples

Download data: TXT

Analysis of blood samples from Fischer animals 16 hours following inhalation of crystalline silica at a concentration of 1 mg/m3, 6 h/day for 5 consecutive days. Results provide insight into the utility of blood gene expression profiling to detect pulmonary toxicity induced by silica.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL6101

Series:

GSE27023

12 Samples

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Analysis of blood samples from Fischer animals 16 hours following inhalation of crystalline silica at a concentration of 2 mg/m3, 6 h/day for 5 consecutive days. Results provide insight into the utility of blood gene expression profiling to detect pulmonary toxicity induced by silica.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL6101

Series:

GSE27023

12 Samples

Download data

Analysis of blood samples from Fischer animals for up to 16 weeks following inhalation of crystalline silica at a concentration of 15 mg/m3, 6 h/day for 5 consecutive days. Results provide insight into the utility of blood gene expression profiling to detect pulmonary toxicity induced by silica.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 6 time sets

Platform:

GPL6101

Series:

GSE27023

72 Samples

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(Submitter supplied) Previous studies have shown that smoking induces oxidative stress and inflammation, known factors that coincide with the development and progression of silicosis. Nevertheless, the precise role of cigarette smoke exposure in silicosis and the underlying mechanisms are not clearly understood. Therefore, the objective of the present study was to determine the effect of smoking, if any, on silica-induced pulmonary response and the underlying mechanisms. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18694

24 Samples

Download data: TXT

(Submitter supplied) The purpose of this work was to identify the potential signatures of cobalt exposure using a toxicogenomic approach. A time course transcriptome analysis was performed on human type II epithelial cell line A549. Cells were exposed to cobalt at midlog phase ; a medium without FCS containing cobalt (CoCl2, Sigma) or not was added for 30mn, 2h, 4h or 24h. Total RNA was isolated using the Quiagen RNeasy miniprep kit, and then labelled using the FairPlay Microarray Labelling Kit (Stratagene). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4263

30 Samples

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(Submitter supplied) We have employed whole genome microarray expression to distinguish the effect of Fumed Silica Nanoparticles on human alveolar epithelial A549 lung cells. Cells were exposed in vitro, and datasets of differentially expressed genes were identified for NPs versus control samples.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

38 Samples

Download data: TXT

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL