GEO DataSets

(Submitter supplied) Background: Right ventricular (RV) and left ventricular (LV) myocardium differ in their response to pressure-overload hypertrophy (POH). In this report we use microarray and proteomic analyses to identify pathways modulated by LV-, and RV-POH in the immature heart. Methods: Newborn New Zealand White rabbits underwent banding of the descending thoracic aorta (LV-POH; n=6). RV-POH was achieved by banding the pulmonary artery (n=6). more...

Organism:

Oryctolagus cuniculus

Type:

Expression profiling by array

Platform:

GPL13758

6 Samples

Download data: GPR

(Submitter supplied) Purpose: While women are more susceptible to pulmonary arterial hypertension (PAH) than men, their right ventricular (RV) function is better preserved. Experimental studies have identified estrogen receptor alpha (ERα) as a likely mediator for estrogen protection in the RV. However, the role of ERα in preserving RV function and remodeling during pressure overload remains poorly understood. We hypothesized that loss of functional ERα removes female protection from adverse remodeling and is permissive for development of a maladapted RV phenotype. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28374

16 Samples

Download data: TXT, XLSX

(Submitter supplied) We recently introduced a modification of the established monocrotaline (MCT) model for pulmonary hypertension (PH) and subsequent right ventricular (RV) hypertrophy, which allows for the selective induction of either a compensate or decompensated RV hypertrophic phenotype within four weeks after a single subcutaneous MCT injection. Both doses of 30 or 80 mg/kg body weight lead to an intermediate phase of compensated RV hypertrophy (day 14-19), while the former dose leads to a stable compensated phenotype (HYP) and the latter dose progresses towards decompensated ventricular hypertrophy and RV failure (CHF) around day 25-28 (Buermans et. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1928

Platform:

GPL1397

27 Samples

Download data: IMAGENE

(Submitter supplied) 14 days after a single subcutaneous monocrotaline (MCT) injection we isolated the left and right ventricles from wistar rats. Factor1: Comparison between control (CON), compensated hypertrophy (HYP), and decompensated hypertrophy (CHF). Factor2: Comparison between left ventricle (LV) and right ventricle (RV). Keywords: dose response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS742

Platform:

GPL1397

24 Samples

Download data

Temporal analysis of right ventricles at the onset of compensated or decompensated right ventricular hypertrophy. Compensated and decompensated phenotypes induced by injection with 30 and 80 mg/kg monocrotaline, respectively. Results identify potential prognostic markers and therapeutic targets.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log2 ratio, 3 disease state, 3 time sets

Platform:

GPL1397

Series:

GSE3675

27 Samples

Download data: IMAGENE

Analysis of compensated and decompensated hypertrophies induced by monocrotaline in Wistar. Left and right heart ventricles examined 14 days after monocrotaline injection. Decompensated hypertrophy is a prelude to chronic heart failure.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 3 disease state, 2 tissue sets

Platform:

GPL1397

Series:

GSE1652

24 Samples

Download data

(Submitter supplied) The right ventricle (RV) differs in several aspects from the left ventricle (LV) including its embryonic origin, physiological role and anatomical design. In contrast to LV hypertrophy, little is known about the molecular circuits, which are activated upon RV hypertrophy (RVH). We established a highly reproducible model of RVH in mice using pulmonary artery clipping (PAC), which avoids detrimental RV pressure overload and thus allows long-term survival of operated mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4545

Platform:

GPL6246

12 Samples

Download data: CEL

Analysis of right ventricle (RV) from C57BL/6 males subjected to hemoclip installation around the pulmonary artery (PA) for up to 6 weeks. PA clipping induces RV hypertrophy (RVH) while avoiding detrimental RV pressure overload. Results provide insight into the molecular basis of RV remodeling.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 protocol, 3 time, 2 tissue sets

Platform:

GPL6246

Series:

GSE30428

12 Samples

Download data: CEL

(Submitter supplied) Background: In complex congenital heart disease patients such as those with tetralogy of Fallot, the right ventricle (RV) is subject to pressure overload, leading to RV hypertrophy and eventually RV failure. The mechanisms that promote the transition from stable RV hypertrophy to RV failure are unknown. We evaluated the role of mitochondrial bioenergetics in the development of RV failure. Methods: We created a murine model of RV pressure overload by pulmonary artery banding and compared with sham-operated controls. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

16 Samples

Download data: TXT, XLSX

(Submitter supplied) Right ventricular failure (RVF) due to pressure load is a major cause of death in congenital heart diseases and pulmonary hypertension. The mechanisms of RVF are yet unknown. Research is hampered by the lack of a good RVF model. Our aim was to study the pathophysiology of RVF in a rat model of chronic pressure load. Wistar rats (n=19) were subjected to pulmonary artery banding (PAB, 1.1mm) or sham surgery (CON). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL11534

16 Samples

Download data: CEL

(Submitter supplied) Background: Current mammalian model for heart regeneration research is limited in apex amputation or myocardium infarction, both of which are controversy. Moreover, RNAseq demonstrated there were a very limited set of differential expressed genes between sham and operation heart in the myocardium infarction model. Here we investigated whether pressure overload in the right ventricle(RV), a common phenomenon in congenital heart disease children, could be a better animal model for heart regeneration study when consider cardiomyocyte(CM) proliferation as the most important index. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18694

12 Samples

Download data: TXT

(Submitter supplied) Gene expression in the right ventricle is different in control patients as compared to either idiopathic dilated cardiomyopathy or pulmonary arterial hypertension

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5610

Platform:

GPL6244

6 Samples

Download data: CEL

Analysis of biopsies of right ventricle (RV) from patients with pulmonary arterial hypertension (PAH) with bone morphogenetic protein receptor type II (BMPR2) mutation. Results provide insight into molecular mechanisms underlying the metabolic effects of mutant BMPR2 in PAH RVs.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state sets

Platform:

GPL6244

Series:

GSE67492

6 Samples

Download data: CEL

(Submitter supplied) We performed RNA-seq to analyze gene expression in rat cardiac tissue from the left and right ventricle for animals in a) normoxia and b) exposed to hypoxia (10% O2) for 2 weeks

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22396

12 Samples

Download data: XLSX

(Submitter supplied) Cardiac fibrosis is a key aspect of heart failure, leading to reduced ventricular compliance and impaired electrical conduction in the myocardium. Various pathophysiologic conditions can lead to fibrosis in the left ventricle (LV) and/or right ventricle (RV). Despite growing evidence to support the transcriptomic heterogeneity of cardiac fibroblasts (CFs) in healthy and diseased states, there have been no direct comparisons of CFs in the LV and RV. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

9 Samples

Download data: H5, TSV

(Submitter supplied) Cardiac fibrosis is a key aspect of heart failure, leading to reduced ventricular compliance and impaired electrical conduction in the myocardium. Various pathophysiologic conditions can lead to fibrosis in the left ventricle (LV) and/or right ventricle (RV). Despite growing evidence to support the transcriptomic heterogeneity of cardiac fibroblasts (CFs) in healthy and diseased states, there have been no direct comparisons of CFs in the LV and RV. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

10 Samples

Download data: MTX, TSV