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Links from GEO DataSets

Items: 10

1.

Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis

(Submitter supplied) Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo [1,2]. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected by SARS-CoV with or without E gene was compared. Twenty-five stress response genes were preferentially upregulated during infection in the absence of the E gene. In addition, genes involved in signal transduction, transcription, cell metabolism, immunoregulation, inflammation, apoptosis and cell cycle and differentiation were differentially regulated in cells infected with rSARS-CoV with or without the E gene. more...
Organism:
Homo sapiens; Chlorocebus aethiops
Type:
Expression profiling by array
Platform:
GPL570
33 Samples
Download data: CEL
Series
Accession:
GSE30589
ID:
200030589
2.

Host responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains

(Submitter supplied) Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease leading to death in 10% of the infected people. A mouse adapted SARS-CoV lacking the envelope (E) protein (rSARS-CoV-MA15-ΔE) is attenuated in vivo. To identify E protein domains and host responses that contribute to rSARS-CoV-MA15-ΔE attenuation, several mutants (rSARS-CoV-MA15-E*) containing point mutations or deletions in the amino-terminal or the carboxy-terminal regions of E protein, respectively, were generated. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
15 Samples
Download data: TXT
Series
Accession:
GSE59185
ID:
200059185
3.

The PDZ-binding motif of SARS-CoV envelope protein is a determinant of viral pathogenesis

(Submitter supplied) A recombinant SARS-CoV lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein interactions, is a major virulence determinant in vivo. Elimination of SARS-CoV E protein PBM by using reverse genetics led to attenuated viruses (SARS-CoV-mutPBM) and to a reduction in the deleterious exacerbate immune response triggered during infection with the parental virus (SARS-CoV-wt). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
9 Samples
Download data: TXT
Series
Accession:
GSE52920
ID:
200052920
4.

SM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.

(Submitter supplied) Purpose of experiment was to perform transcriptomic analysis on C57Bl/6 mice infected with different doses of SARS CoV MA15 at 4 different days post infection.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
92 Samples
Download data: TXT
Series
Accession:
GSE33266
ID:
200033266
5.

Comparative Pathogenesis of Three Human and Zoonotic SARS-CoV Strains in Cynomolgus Macaques

(Submitter supplied) The severe acute respiratory syndrome (SARS) epidemic was characterized by increased pathogenicity in the elderly due to an early exacerbated innate host response. SARS-CoV is a zoonotic pathogen that entered the human population through an intermediate host like the palm civet. To prevent future introductions of zoonotic SARS-CoV strains and subsequent transmission into the human population, heterologous disease models are needed to test the efficacy of vaccines and therapeutics against both late human and zoonotic isolates. more...
Organism:
Macaca mulatta
Type:
Expression profiling by array
Platform:
GPL3535
30 Samples
Download data: CEL, CHP
Series
Accession:
GSE23955
ID:
200023955
6.

SARS-CoV-Encoded Small RNAs Contribute to Infection-Associated Lung Pathology

(Submitter supplied) Severe acute respiratory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exacerbated inflammatory response and extensive lung pathology. To address the relevance of small non-coding RNAs in SARS-CoV pathology, we deep sequenced RNAs from the lungs of infected mice and discovered three 18–22 nt small viral RNAs (svRNAs). The three svRNAs were derived from the nsp3 (svRNA-nsp3.1 and -nsp3.2) and N (svRNA-N) genomic regions of SARS-CoV. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL15103
16 Samples
Download data: TXT
Series
Accession:
GSE90624
ID:
200090624
7.

Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation

(Submitter supplied) Background: Type I interferons (IFNs) are essential to the clearance of viral diseases, in part by initiating upregulation of IFN regulated genes (IRGs). A clear distinction between genes upregulated directly by virus and genes upregulated by secondary IFN production has not been made. Here we investigated the genes regulated by IFN-a2b compared to the genes regulated by SARS-CoV infection in ferrets. more...
Organism:
Canis lupus familiaris; Mustela putorius furo
Type:
Expression profiling by array
Platform:
GPL3738
43 Samples
Download data: CEL
Series
Accession:
GSE22581
ID:
200022581
8.

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

(Submitter supplied) RNA was isolated from the lungs of mock and infected control and Trim55-/- mice at 2 and 4 DPI.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
21 Samples
Download data: TXT
Series
Accession:
GSE64660
ID:
200064660
9.

Gene expression pattern of pulmonary CD11c+ cells from middle-aged and young mice.

(Submitter supplied) Analysis of function of CD11c+ cells from middle-aged and young mice at gene level. This experiment provided insight into the different genes that plays roles in inflammation, immune response and mainly arachidonic acid cascade that are differentiall expressed in CD11c+ cells from middle aged and young mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5879
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE71868
ID:
200071868
10.
Full record GDS5879

Pulmonary CDC11c+ cells from young and middle-age animals

Analysis of pulmonary CDC11c+ cells from 6-8 week and 10-13 month old C57BL/6 animals. CDC11c+ cells are key modulators of the immune response in the lung. Results provide insight into molecular mechanisms underlying the decline in immune function associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL6885
Series:
GSE71868
8 Samples
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