GEO DataSets

(Submitter supplied) We report the gene expression profile of human endometriual stromal cells and armadillo endometrial samples

Organism:

Monodelphis domestica; Homo sapiens; Dasypus novemcinctus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL13923 GPL17258 GPL9115

4 Samples

Download data: TXT

(Submitter supplied) A major challenge in biology is to determine how evolutionarily novel characters originate, however, mechanistic explanations for the origin of novelties are almost completely unknown. The evolution of mammalian pregnancy is an excellent system in which to study the origin of novelties because extant mammals preserve major stages in the transition from egg-laying to live-birth. To determine the molecular bases of this transition we characterized the pregnant/gravid uterine transcriptome from tetrapods, including species in the three major mammalian lineages, and used ancestral transcriptome reconstruction to trace the evolutionary history of uterine gene expression. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL9115 GPL11154

13 Samples

Download data: BED, WIG

(Submitter supplied) A major challenge in biology is to determine how evolutionarily novel characters originate, however, mechanistic explanations for the origin of novelties are almost completely unknown. The evolution of mammalian pregnancy is an excellent system in which to study the origin of novelties because extant mammals preserve major stages in the transition from egg-laying to live-birth. To determine the molecular bases of this transition, we characterized the pregnant/gravid uterine transcriptome from tetrapods, including species in the three major mammalian lineages, and used ancestral transcriptome reconstruction to trace the evolutionary history of uterine gene expression. more...

Organism:

Ornithorhynchus anatinus; Canis lupus familiaris; Dasypus novemcinctus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL18702 GPL18701 GPL13923

3 Samples

Download data: TXT

(Submitter supplied) Pregnancy loss is the most common complication of human pregnancy. Recurrent early pregnancy loss (REPL) has multiple etiologies, including endometrial dysregulation leading to “suboptimal” implantation. Although the implantation process is tightly regulated in Eutherian (placental) mammals, the molecular factors contributing to dysregulated endometrial gene expression patterns in women with REPL are largely unknown. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

84 Samples

Download data: IDAT, TXT

(Submitter supplied) To further explore the function of Mtf2, the homolog of Drosophila Polycomb group gene PCL, we have employed the mouse whole genome microarray expression profiling as a discovery platform to identify genes mediated by Mtf2. Oligos of 2 different RNAi target sites on gene Mtf2 were cloned into RNAi Vector pSuper and transfected individually into Mouse Embryonic Stem Cell line E14. Empty Vector pSuper and plasmid containing RNAi target against gene Luciferase (Firefly) were performed in the same way as negative controls. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

4 Samples

Download data: GPR

(Submitter supplied) The process of early development of mammals is subtly and accurately controlled by the regulation networks of embryo cells. Time course expression data measured at different stages during early embryo development process can give us valuable information by revealing the dynamic expression patterns of genes in genome wide scale. In this study, bovine embryo expression data were generated at oocyte, one cell stage, two cell stage, four cell stage, eight cell stage, sixteen cell stage, morula, and blastocyst; Human embryo expression data were generated at one cell stage, two cell stage, four cell stage, eight cell stage, morula, and blastocyst; Mouse embryo expression data were generated at one cell stage, two cell stage, four cell stage, eight cell stage, morula, and blastocyst. more...

Organism:

Homo sapiens; Bos taurus; Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3958 GDS3959 GDS3960

Platforms:

GPL2112 GPL570 GPL339

52 Samples

Download data: CEL

Analysis of embryos at different stages of preimplantation embryonic development (PED): oocyte, one-cell, two-cell, four-cell, eight-cell, 16-cell, morula, and blastocyst. The progression of PED is highly conserved among mammals. Results provide insight into molecular mechanisms underlying PED.

Organism:

Bos taurus

Type:

Expression profiling by array, count, 8 development stage sets

Platform:

GPL2112

Series:

GSE18290

16 Samples

Download data: CEL

Analysis of embryos at different stages of preimplantation embryonic development (PED): one-cell, two-cell, four-cell, eight-cell, morula, and blastocyst. The progression of PED is highly conserved among mammals. Results provide insight into molecular mechanisms underlying PED.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 6 development stage sets

Platform:

GPL570

Series:

GSE18290

18 Samples

Download data: CEL

Analysis of embryos at different stages of preimplantation embryonic development (PED): one-cell, two-cell, four-cell, eight-cell, morula, and blastocyst. The progression of PED is highly conserved among mammals. Results provide insight into molecular mechanisms underlying PED.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 6 development stage sets

Platform:

GPL339

Series:

GSE18290

18 Samples

Download data: CEL

(Submitter supplied) The goal of this study is to analyze the contribution of transposable elements (TEs) tocis-regulation in CD8+ T cells. Using a combination of NGS techniques we show that specific subfamilies of TEs are enriched, and distributed in a lineage-specific fashion in core and boundary domains of CD8+T cell enhancers.This study represents the first detailed analysis of the topology and the enhancer domain-associated putative functions of distinct TE types.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL17021

23 Samples

Download data: BW, WIG

(Submitter supplied) Encoded in the hundreds by the human genome, KRAB-containing zinc finger proteins (KRAB-ZFPs) constitute a rapidly evolving family of transcription factors with largely undefined functions. Here, by a combination of phylogenetic and genomic approaches, we retrace the evolutionary history of KRAB-ZFP genes and define the genomic targets of their human products. Through in silico analysis of 207 vertebrate genomes and chromatin immunoprecipitation / deep sequencing characterization of 257 human KRAB-ZFPs, we identify the root of the family in an early Devonian ancestor of tetrapods, describe its diversity amongst these species, and reveal that the majority of its human members primarily recognize transposable elements. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL16791

237 Samples

Download data: BED

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:

GPL11002 GPL17021

14 Samples

Download data

(Submitter supplied) The placenta is an understudied organ that has a critical role in mammalian development. In early placental development, the essential process of trophoblast invasion establishes adequate blood flow between mother and fetus. Despite its importance, little is known about the genomic regions responsible for regulating trophoblast invasion. In order to identify enhancers that are important for regulating the process, we carried out ChIP-Seq for an enhancer-associated mark at two time points during early placental development. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

6 Samples

Download data: TXT

(Submitter supplied) The placenta is an understudied organ that has a critical role in mammalian development. In early placental development, the essential process of trophoblast invasion establishes adequate blood flow between mother and fetus. Despite its importance, little is known about the genomic regions responsible for regulating trophoblast invasion. In order to identify enhancers that are important for regulating the process, we carried out ChIP-Seq for an enhancer-associated mark at two time points during early placental development. more...

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL11002

8 Samples

Download data: BED

(Submitter supplied) Transcriptional profiling of heat-shocked worms was compared to non-heat-shocked worms to determine genes that are induced upon heat shock in each species; heat-shock-induced genes in each species were compared

Organism:

Caenorhabditis briggsae; Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL27110 GPL22765

12 Samples

Download data: TXT