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Links from GEO DataSets

Items: 6

1.

Differences in gene expression patterns in mouse embryonic fibroblast Flp-In-3T3 cell lines stably expressing Pax6 or Pax6(5a).

(Submitter supplied) Novel target genes for the two transcription factor isoforms Pax6 and Pax6(5a) were identified by generating mouse embryonic fibroblast cell lines stably expressing either Pax6 or Pax6(5a), and comparing their gene expression pattern with the original mouse embryonic fibroblast cell line.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
8 Samples
Download data: TXT
Series
Accession:
GSE31402
ID:
200031402
2.

Functional dissection of the Paired domain of Pax6 – distinct roles of subdomains in neurogenesis and proliferation

(Submitter supplied) The transcription factor Pax6 acts as a key developmental regulator in various organs. In the developing brain Pax6 regulates patterning, neurogenesis and proliferation, but how these diverse effects are mediated at the molecular level is not well understood. As Pax6 regulates forebrain development including neurogenesis, proliferation and patterning, almost exclusively by one of its DNA-binding domains, the bipartite paired domain, we examined the role of its respective DNA-binding subdomains (PAI and RED). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
21 Samples
Download data: CEL
Series
Accession:
GSE35260
ID:
200035260
3.

Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during lens and forebrain development

(Submitter supplied) The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation and cell fate specification. Pax6 also regulates the entire lens developmental program. To reconstruct Pax6-dependent gene regulatory networks (GRNs), ChIP-seq studies were performed using lens and forebrain chromatin from mice. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL11002 GPL17021
24 Samples
Download data: BED, NARROWPEAK, TXT
Series
Accession:
GSE66961
ID:
200066961
4.

Pax6 mutant neocortex vs. wild type

(Submitter supplied) Pax6 is a transcription factor with key functional roles in embryonic development. In order to identify downstream effectors of Pax6 in the developing cerebral cortex we performed microarray analysis. We compared gene expression profiles of cortical tissues isolated from wild type and Pax6-/- mouse embryos.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
2 Samples
Download data: CEL
Series
Accession:
GSE32271
ID:
200032271
5.

Identification of Pax6-dependent gene regulatory networks in the mouse lens

(Submitter supplied) This is an integrative genome-wide approach to identify downstream networks controlled by Pax6 during mouse lens and forebrain development. Differential gene expression was analyzed in Pax6 mouse heterozygous and wildtype newborn mouse lenses, with subsequent comparison of this data with Pax6 forebrain expression data (Holm et al., 2007). Keywords: Differential gene expression
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
6 Samples
Download data: CEL
Series
Accession:
GSE13244
ID:
200013244
6.

E12.5 Murine lateral cortical progenitor cells: Pax6sey/sey vs. Pax6+/+

(Submitter supplied) The mechanisms by which the early spatiotemporal expression patterns of transcription factors such as Pax6 regulate the region-specific proliferation rates of neural progenitors are poorly understood. Pax6 is expressed in a gradient across the developing cortex and is essential for normal corticogenesis. We found that constitutive or conditional loss of Pax6 increases cortical progenitor proliferation by amounts that vary regionally with normal Pax6 levels. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2872
3 Samples
Download data: TXT
Series
Accession:
GSE38703
ID:
200038703
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