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Links from GEO DataSets

Items: 20

1.

Tissue-specific differences in PPARγ control of macrophage function.

(Submitter supplied) PPARγ is known for its anti-inflammatory actions in macrophages. However, which macrophage populations express PPARγ in vivo and how it regulates tissue homeostasis in the steady state and during inflammation is not completely understood. We show that lung and spleen macrophages constitutively expressed PPARγ, while other macrophage populations did not. Recruitment of monocytes to sites of inflammation was associated with induction of PPARγ as they differentiated to macrophages. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
14 Samples
Download data: CEL
Series
Accession:
GSE32034
ID:
200032034
2.

Identification of PPARG regulated genes in human GM-CSF-primed monocyte-derived macrophages

(Submitter supplied) Identification of PPARG regulated genes in human GM-CSF polarized monocyte-derived macrophages by siRNA knock-down approaches.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL21185
6 Samples
Download data: TXT
Series
Accession:
GSE88768
ID:
200088768
3.

Transcriptional analysis of PPARgamma activation in control and PPARgamma null macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL13112
38 Samples
Download data: BIGWIG
Series
Accession:
GSE111105
ID:
200111105
4.

Transcriptional analysis of PPARgamma activation in control and PPARgamma null macrophages [ChIP-seq]

(Submitter supplied) The nuclear receptor Peroxisome Proliferator Activated Receptor gamma (PPARgamma) is known to regulate lipid metabolism in many tissues, including macrophages. Here we report that macrophage respiration is enhanced by rosiglitazone, an activating PPARgamma ligand, in a PPARgamma dependent manner. Moreover, PPARgamma is required for macrophage respiration even in the absence of exogenous ligand. Unexpectedly, the absence of PPARgamma dramatically affects the oxidation of glutamine. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data: BIGWIG
Series
Accession:
GSE111104
ID:
200111104
5.

Transcriptional analysis of PPARgamma activation in control and PPARgamma null macrophages [GRO-seq]

(Submitter supplied) The nuclear receptor Peroxisome Proliferator Activated Receptor gamma (PPARgamma) is known to regulate lipid metabolism in many tissues, including macrophages. Here we report that macrophage respiration is enhanced by rosiglitazone, an activating PPARgamma ligand, in a PPARgamma dependent manner. Moreover, PPARgamma is required for macrophage respiration even in the absence of exogenous ligand. Unexpectedly, the absence of PPARgamma dramatically affects the oxidation of glutamine. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL13112
5 Samples
Download data: BIGWIG
6.

Transcriptional analysis of PPARgamma activation in control and PPARgamma null macrophages [RNA-seq]

(Submitter supplied) The nuclear receptor Peroxisome Proliferator Activated Receptor gamma (PPARgamma) is known to regulate lipid metabolism in many tissues, including macrophages. Here we report that macrophage respiration is enhanced by rosiglitazone, an activating PPARgamma ligand, in a PPARgamma dependent manner. Moreover, PPARgamma is required for macrophage respiration even in the absence of exogenous ligand. Unexpectedly, the absence of PPARgamma dramatically affects the oxidation of glutamine. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
31 Samples
Download data: XLSX
Series
Accession:
GSE111102
ID:
200111102
7.

PPARγ controls alveolar macrophage identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
12 Samples
Download data: CEL
Series
Accession:
GSE60249
ID:
200060249
8.

PPARγ controls alveolar macrophage identity [part2]

(Submitter supplied) Tissue-resident macrophages comprise heterogeneous populations with unique functions and distinct gene expression signatures. While it has been established that they mostly originate from embryonic progenitors, the signals inducing a characteristic tissue-specific differentiation program remain unknown. Here we identify PPARγ as the crucial transcription factor determining perinatal alveolar macrophage (AM) development and identity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
4 Samples
Download data: CEL
Series
Accession:
GSE60248
ID:
200060248
9.

PPARγ controls alveolar macrophage identity [part1]

(Submitter supplied) Tissue-resident macrophages comprise heterogeneous populations with unique functions and distinct gene expression signatures. While it has been established that they mostly originate from embryonic progenitors, the signals inducing a characteristic tissue-specific differentiation program remain unknown. Here we identify PPARγ as the crucial transcription factor determining perinatal alveolar macrophage (AM) development and identity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
8 Samples
Download data: CEL
Series
Accession:
GSE60247
ID:
200060247
10.

Expression data from PPARg WT and KO macrophages

(Submitter supplied) PPARg is a nuclear receptor that plays an important role in lipid metabolism, homeostasis and immunity. Microarray analysis of gene expression was performed in macrophages from WT and PPARg KO mice. Differentially expressed genes were selected for further analysis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE24292
ID:
200024292
11.

Sema6D reverse signaling controls lipid metabolism for macrophage polarization linking mTOR to PPARγ

(Submitter supplied) Purpose: The goal of this study is to compare downstream genes of Sema6D signaling in LPS plus IFNg stimulated macrophages. Methods: Bone marrow derived macrophage mRNA profiles of 7 weeks of wild type (WT) and Sema6D-/- mice were stimulated by LPS for 4 hrs. Results: According to this comparison, we found that 550 genes were downregulated in Sema6D-/- macrophages than WT macrophages in response to LPS. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: TXT
Series
Accession:
GSE99047
ID:
200099047
12.

Sema6D reverse signaling controls lipid metabolism for macrophage polarization linking mTOR to PPARγ

(Submitter supplied) The goal of this study is to compare downstream genes of Sema6D signaling in both M1 and M2 macrophages.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE99046
ID:
200099046
13.

The lung environment controls alveolar macrophage metabolism and responsiveness during type-2 inflammation.

(Submitter supplied) Fine control of macrophage activation is required to prevent inflammatory disease, particularly at barrier sites such as the lung. However, the dominant mechanisms that regulate pulmonary MΦs during inflammation are currently poorly understood. Here we show that airway MΦs are substantially less able to respond to the canonical type-2 cytokine IL-4, which underpins allergic disease and parasite worm infections, than lung tissue or peritoneal cavity MΦs. We reveal that MΦ hypo-responsiveness to IL-4 is dictated by the lung environment, though independent of the host microbiota or the prominent lung extracellular matrix components surfactant protein D and mucin 5b. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
13 Samples
Download data: TXT
Series
Accession:
GSE126309
ID:
200126309
14.

Transcriptional profle of bronchoalveolar cells in sarcoidosis

(Submitter supplied) Introduction: Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased approach to identify pathways activated in alveolar macrophages—a key immuno-inflammatory cell in the lung—can shed light on the pathogenesis of this complex disease. Methods: We recruited 15 patients with various stages of sarcoidosis and 12 healthy controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
27 Samples
Download data: CEL
Series
Accession:
GSE75023
ID:
200075023
15.

mRNA expression data from either wild-type mice or Scnn1b-transgenic mice at post-natal days 0, 3, 10, and 42

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6246 GPL11533
84 Samples
Download data: CEL
Series
Accession:
GSE47551
ID:
200047551
16.

mRNA expression data from whole trachea dissected from either wild-type mice or Scnn1b-Tg mice at post-natal days 0, 3, 10, and 42

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84; and Livraghi-Butrico et al. 2012, Mucosal Immunology 5(4):397-408). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE47550
ID:
200047550
17.

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; and Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84. Briefly, overexpression of the Scnn1b transgene in airway Club cells leads to hyperabsorption of sodium from the airway surface liquid, dehydrated airway surface liquid and mucus, and reduced mucus clearance associated with accumulation of mucus plugs/plaques. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
36 Samples
Download data: CEL
Series
Accession:
GSE47548
ID:
200047548
18.

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration [left lobe only]

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84; and Livraghi-Butrico et al. 2012, Mucosal Immunology 5(4):397-408). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE47546
ID:
200047546
19.

Ontogeny of alveolar macrophages is a critical determinant of function during lung fibrosis [RNA-seq]

(Submitter supplied) Little is known about the relative importance of monocyte and tissue-resident macrophages in the development of lung fibrosis. We show that specific genetic deletion of monocyte-derived alveolar macrophages after their recruitment to the lung ameliorated lung fibrosis, whereas tissue-resident alveolar macrophages did not contribute to fibrosis. Using transcriptomic profiling of flow-sorted cells, we found that monocyte to alveolar macrophage differentiation unfolds continuously over the course of fibrosis and its resolution. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
163 Samples
Download data: TXT
Series
Accession:
GSE82158
ID:
200082158
20.

Organ-specific tissue-resident macrophages dynamics during blood stage malaria

(Submitter supplied) Blood-stage malaria initiates both innate and adaptive immune responses, inclusive a strong activation of the mononuclear phagocyte network. Here we show that Plasmodium infection results in a transient loss of embryonically established tissue-resident macrophages in spleen, liver and lungs, much before the peak of parasitemia. During acute blood-stage malaria, fate mapping analysis revealed that inflammatory monocytes contribute to the repopulation of the emptied niches of splenic red pulp macrophages and hepatic Kupffer cells, while lung alveolar macrophages refill their niche mainly through self-renewal. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
18 Samples
Download data: TXT
Series
Accession:
GSE115906
ID:
200115906
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