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Links from GEO DataSets

Items: 6

1.

Effect of Concentration and type of Dietary Fatty Acid on Development of Nonalcoholic Fatty Liver Disease

(Submitter supplied) The current study was designed to determine if dietary fatty acid concentration and composition affects the development and progression of nonalcoholic fatty liver disease. Male SD rats were overfed diets low (5%) or high (70%) fat diets via total enteral nutrition where the fat source was olive oil (monounsaturated), or corn oil (polyunsaturated). Overfeeding 5% corn oil produced little steatosis relative to feeding 5% olive oil. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL85
12 Samples
Download data: CEL
Series
Accession:
GSE33166
ID:
200033166
2.

Non-alcoholic Steatohepatitis following feeding of high polyunsaturated fat diets

(Submitter supplied) Most commonly used models of non-alcoholic steatohepatitis (NASH) are diets based on specific gene knockouts or represent extreme manipulations of diet. We have examined the effects of modest increased caloric intake and high dietary unsaturated fat content on the development of NASH in male rats using a model in which overfeeding is accomplished via intragastric infusion of liquid diets as a part of total enteral nutrition. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3431
Platform:
GPL85
6 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE8253
ID:
200008253
3.
Full record GDS3431

Non-alcoholic steatohepatitis model

Analysis of livers from males fed a high polyunsaturated diet containing 70% corn oil to induce the development of non-alcoholic steatohepatitis (NASH). In NASH, steatosis is accompanied by inflammation, necrosis, apoptosis, and fibrosis. Results provide insight into the pathogenesis of NASH.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL85
Series:
GSE8253
6 Samples
Download data: CEL, CHP, EXP
DataSet
Accession:
GDS3431
ID:
3431
4.

Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine

(Submitter supplied) We studied the effect of dietary fat type, varying in polyunsaturated/saturated fatty acid ratio's (P/S) on development of metabolic syndrome. C57Bl/6J mice were fed purified high-fat diets (45E% fat) containing palm oil (HF-PO; P/S 0.4), olive oil (HF-OO; P/S 1.1) or safflower oil (HF-SO; P/S 7.8) for 8 weeks. A low-fat palm oil diet (LF-PO; 10E% fat) was used as a reference. Additionally, we analyzed diet-induced changes in gut microbiota composition and mucosal gene expression. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4339
Platform:
GPL1261
9 Samples
Download data: CEL
Series
Accession:
GSE18586
ID:
200018586
5.
Full record GDS4339

Dietary saturated fat effect on small intestine

Analysis of small intestine divided into 3 equal parts along the proximal to distal axis (SI 1, SI 2, SI 3) from C57Bl/6J males fed high-fat diets varying in polyunsaturated/saturated fatty acid ratios (P/S). Results provide insight into role of dietary fat type on development of metabolic syndrome.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 agent, 3 tissue sets
Platform:
GPL1261
Series:
GSE18586
9 Samples
Download data: CEL
DataSet
Accession:
GDS4339
ID:
4339
6.

Microarray Analysis of Hepatic Genes Differentially Expressed in the Presence of the Maslinic Acid in Olive Oil

(Submitter supplied) Two olive oils only differing in the presence of maslinic acid were prepared. Using DNA microarrays, hepatic gene expression was analysed in apoE-deficient mice with a C57BL/6J genetic background Keywords: diet study
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
2 Samples
Download data: CEL
Series
Accession:
GSE7091
ID:
200007091
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