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Links from GEO DataSets

Items: 20

1.

Expression data from peripheral blood - blood draws at Pre and Post time points of Allergen inhalation challenge (PAX.NGR)

(Submitter supplied) Detecting differential changes in the peripheral whole-blood transcriptome, post-challenge compared to pre-challenge; using non-globin reduced PAXgene (PAX.NGR) tubes Blood was collected immediately prior to, and two hours after challenge
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
8 Samples
Download data: CEL
Series
Accession:
GSE34159
ID:
200034159
2.

Expression data from peripheral blood - blood draws at Pre and Post time points of Allergen inhalation challenge

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
34 Samples
Download data: CEL
Series
Accession:
GSE34172
ID:
200034172
3.

Expression data from peripheral blood - blood draws at Pre and Post time points of Allergen inhalation challenge (PAX.NGR and EDTA)

(Submitter supplied) To determine differential gene expression in peripheral blood of asthmatic individuals undergoing allergen inhalation challenge, post-challenge compared to pre-challenge
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
18 Samples
Download data: CEL
Series
Accession:
GSE34160
ID:
200034160
4.

Expression data from peripheral blood - blood draws at Pre and Post time points of Allergen inhalation challenge (PAX.GR)

(Submitter supplied) Detecting differential changes in the peripheral whole-blood transcriptome, post-challenge compared to pre-challenge; using globin reduced PAXgene (PAX.GR) tubes
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
8 Samples
Download data: CEL
Series
Accession:
GSE34158
ID:
200034158
5.

Transcriptional profiling of peripheral blood - comparison of results obtained from samples stored in two RNA stabilizing reagents

(Submitter supplied) RNA stabilizing reagents have been developed to ensure that transcription profiles of whole blood samples reflect the physiological state at the time of the blood drawn. Ability to preserve and maintain the in vivo gene expression status ex vivo is essential for gene expression profiling and biomarker discovery from clinical sample material. We compared transcriptional profiles obtained from samples collected using two established peripheral blood RNA collection systems, TEMPUS™ and PAXgene™. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2700
14 Samples
Download data: TXT
Series
Accession:
GSE29487
ID:
200029487
6.

Expression data from peripheral blood - blood draws at Pre and Post time points of Allergen inhalation challenge (ER and DR)

(Submitter supplied) To determine differential gene expression in peripheral blood of asthmatic individuals undergoing allergen inhalation challenge between early responders (ERs) and dual responders (DRs) following allergen inhalation challenge
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5001
Platform:
GPL6244
28 Samples
Download data: CEL
Series
Accession:
GSE40240
ID:
200040240
7.
Full record GDS5001

Allergen inhalation challenge effect on peripheral blood of asthmatic early responders and dual responders

Analysis of blood collected from asthmatics immediately prior to, and two hours after, cat allergen challenge. Some asthmatics are early responders while others are dual (early plus late) responders. Results provide insight into the molecular mechanisms underlying early and dual asthmatic responses.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 10 age, 2 gender, 14 individual, 2 other, 2 protocol sets
Platform:
GPL6244
Series:
GSE40240
28 Samples
Download data: CEL
8.

microRNA expression data in bronchial epithelial cells from healthy and asthmatic donors

(Submitter supplied) Airway inflammation is the hallmark of asthma and suggests a dysregulation of homeostatic mechanisms. MicroRNAs (miRNAs) are key regulators of gene expression, necessary for the proper function of cellular processes. We used miRNA microarrays to compare the profiles of human bronchial epithelial cells from healthy and asthmatic donors
Organism:
Homo sapiens; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL8786
14 Samples
Download data: CEL
Series
Accession:
GSE25230
ID:
200025230
9.

Gene Expression Profiling of Whole Blood: Comparison of target preparation methods

(Submitter supplied) Peripheral blood is an accessible and informative source of transcriptomal information for many human disease and pharmacogenomic studies. While there can be significant advantages to analyzing RNA isolated from whole blood, particularly in clinical studies, the preparation of samples for microarray analysis is complicated by the need to minimize artifacts associated with highly abundant globin RNA transcripts. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL201
24 Samples
Download data: CEL, CHP
Series
Accession:
GSE13292
ID:
200013292
10.

Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA

(Submitter supplied) Transcriptome analysis is of great interest in clinical research, where significant differences between individuals can be translated into biomarkers of disease. Although next generation sequencing provides robust, comparable and highly informative expression profiling data, with several million of tags per blood sample, reticulocyte globin transcripts can constitute up to 76% of total mRNA compromising the detection of low abundant transcripts. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL10999
12 Samples
Download data: TXT
Series
Accession:
GSE33701
ID:
200033701
11.

Variation in RNA-Seq transcriptome profiles of peripheral whole blood from healthy individuals with and without globin depletion

(Submitter supplied) In this study we aimed to assess technical variability associated with globin depletion in addition to assessing general technical variability in RNA-Seq from whole blood derived samples. We compared technical and biological replicates having undergone globin depletion or not and found that globin depletion removed approximately 80% of globin transcripts, improved the correlation of technical replicates, allowed for reliable detection of thousands of additional transcripts and generally increased transcript abundance measures.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
47 Samples
Download data: TXT
Series
Accession:
GSE53655
ID:
200053655
12.

Microarray characterization of gene expression changes in blood during acute ethanol exposure

(Submitter supplied) As part of the civil aviation safety program to define the adverse effects of ethanol on flying performance, we present results of our DNA microarray analysis of samples from a timecourse study of individuals given ethanol orally, and then evaluated by breathalyzer to monitor blood alcohol content (BAC). At five blood alcohol levels, T1-T5, blood was drawn such that the samples represented 0%, 0.04%, 0.08% BAC, and return to 0.04%, and 0.02% BAC. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS4938 GDS6177
Platform:
GPL570
54 Samples
Download data: CEL
Series
Accession:
GSE20489
ID:
200020489
13.
Full record GDS6177

Acute alcohol consumption effect on whole blood (control group): time course

Analysis of blood from subjects administered orange juice w/o alcohol. Blood collected at time points corresponding to collection times for the alcohol group in GDS4938. These results, together with those from GDS4938, provide insight into molecular response of blood during acute ethanol exposure.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 individual, 2 protocol, 5 time sets
Platform:
GPL570
Series:
GSE20489
25 Samples
Download data: CEL
14.
Full record GDS4938

Acute alcohol consumption effect on whole blood (alcohol group): time course

Analysis of blood from subjects administered orange juice with ethanol. Blood collected at Blood Alcohol Concentrations of 0%, 0.04%, 0.08%, declining 0.04% and 0.02%. These results, together with those from GDS6177, provide insight into molecular response of blood during acute ethanol exposure.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 6 individual, 2 protocol, 5 time sets
Platform:
GPL570
Series:
GSE20489
29 Samples
Download data: CEL
15.

Effects of allergen challenge on airway epithelial cell gene expression

(Submitter supplied) Allergen exposure induces the airway epithelium to produce chemoattractants, proallergic interleukins, matrix-modifying proteins, and proteins that influence the growth and activation state of airway structural cells. These proteins, in turn, contribute to the influx of inflammatory cells and changes in structure that characterize the asthmatic airway. To use the response of the airway epithelium to allergen to identify genes not previously associated with allergic responses, we compared gene expression in cytokeratin-positive cells before and after segmental allergen challenge. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8300
10 Samples
Download data
Series
Accession:
GSE3004
ID:
200003004
16.

Comparison of two sets of microarray experiments to define allergic asthma expression pattern

(Submitter supplied) Allergic asthma is a complex trait. Several approaches have been used to identify biomarkers involved in this disease. This study aimed at demonstrating the relevance and validity of microarrays in the definition of allergic asthma expression pattern. The authors compared the transcript expressions of bronchial biopsy of 2 different microarray experiments done 2 years apart, both including nonallergic healthy and allergic asthmatic subjects (n = 4 in each experiment). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4418
Platform:
GPL96
8 Samples
Download data: CEL
Series
Accession:
GSE41649
ID:
200041649
17.
Full record GDS4418

Allergic asthma: bronchial biopsies

Analysis of bronchial biopsies from allergic asthma (AA) subjects. These results, together with those from GDS4417 (a study with similar specimen collection procedures, but different subjects, GeneChips, data processing), provide insight into molecular mechanisms underlying AA pathophysiology.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL96
Series:
GSE41649
8 Samples
Download data: CEL
DataSet
Accession:
GDS4418
ID:
4418
18.

Gene Expression Profiling of Human Whole Blood Samples with the Illumina WG-DASL Assay

(Submitter supplied) Microarray-based gene expression analysis of peripheral whole blood is a common strategy in the development of clinically relevant biomarker panels for a variety of human diseases. However, the results of such an analysis are often plagued by decreased sensitivity and reliability due to the effects of relatively high levels of globin mRNA in whole blood. Globin reduction assays have been shown to overcome such effects, but they require large amounts of total RNA and may induce distinct gene expression profiles. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6883 GPL8432
64 Samples
Download data
Series
Accession:
GSE28064
ID:
200028064
19.

Expression data from uremic patients and 20 healthy controls (normals)

(Submitter supplied) Renal failure is characterized by important biological changes resulting in profound pleomorphic physiological effects termed “uremia”, whose molecular causation is not well understood. The data was used to study gene expression changes in uremia using whole genome microarray analysis of peripheral blood from subjects with end-stage renal failure (n=63) and healthy controls (n=20) to obtain insight into the molecular and biological causation of this syndrome.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
115 Samples
Download data: CEL
Series
Accession:
GSE37171
ID:
200037171
20.

Expression data from severe asthmatics, mild asthmatics and healthy controls

(Submitter supplied) Background: Around 5% of children with asthma suffer from chronic symptoms and/or severe exacerbations despite extensive treatment. The causes of severe therapy-resistant childhood asthma are poorly understood. Objectives: To define global patterns of gene expression in severe therapy-resistant vs. controlled asthma and healthy controls. Methods: Children with severe, therapy-resistant (SA, n=20) and controlled asthma (CA, n=20) were identified from a Swedish nation-wide study including extensive clinical and immunological characterisation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4896
Platform:
GPL6244
54 Samples
Download data: CEL
Series
Accession:
GSE27011
ID:
200027011
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