GEO DataSets

(Submitter supplied) The CRISPR-Cas system represents an RNA-based adaptive immune response system in prokaryotes. CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats) consist of arrays of short repeat sequences interspaced by non-repetitive short spacers, some of which show sequence similarity to foreign phage genetic elements. Their cistronic transcripts are processed to produce the mature CRISPR RNAs (crRNAs), the elements that confer immunity by base-pairing with exogenous nucleic acids. more...

Organism:

Thermus thermophilus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL14992 GPL14993

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Thermus thermophilus HB8

Type:

Expression profiling by array

Platform:

GPL4902

24 Samples

Download data: CEL

(Submitter supplied) We observed the expression profile of the total mRNA in crp (TTHA1437) deletion mutant strain of Thermus thermophilus HB8 during infection of bacteriophage ϕYS40. Keywords: time course, bacteriophage, infection, CRP, cAMP receptor protein, deletion mutant

Organism:

Thermus thermophilus HB8

Type:

Expression profiling by array

Platform:

GPL4902

9 Samples

Download data: CEL

(Submitter supplied) We observed the expression profile of the total mRNA of wild-type Thermus thermophilus HB8 strain during infection of bacteriophage ϕYS40. Keywords: time course, bacteriophage, infection, wild type

Organism:

Thermus thermophilus HB8

Type:

Expression profiling by array

Platform:

GPL4902

15 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Thermus thermophilus HB8

Type:

Expression profiling by array

Platform:

GPL4902

41 Samples

Download data: CEL

(Submitter supplied) We observed the expression profile of the total mRNA of crp (TTHA1437) deletion mutant of Thermus thermophilus HB8 strain grown in a rich (TT) medium at 70oC compared with that of wild type. Keywords: cell type comparison

Organism:

Thermus thermophilus HB8

Type:

Expression profiling by array

Platform:

GPL4902

12 Samples

Download data: CEL

(Submitter supplied) We observed the expression profile of the total mRNA of wild-type Thermus thermophilus HB8 strain grown in a rich (TT) medium at 70oC. Keywords: time course

Organism:

Thermus thermophilus HB8

Type:

Expression profiling by array

Platform:

GPL4902

30 Samples

Download data: CEL

(Submitter supplied) We have previously reported that Mycobacterium tuberculosis Rv2837c (cnpB) encodes a phosphodiesterase that specifically cleaves cyclic di-AMP (c-di-AMP) into AMP. Deletion of cnpB results in significant virulence attenuation in a mouse pulmonary infection model, which is very likely due to the significantly elevated c-di-AMP levels as overexpression of Mtb diadenylate cyclase, disA, also leads to a similar outcome. more...

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18768

6 Samples

Download data: XLSX

(Submitter supplied) CRISPR-Cas immune systems function to defend prokaryotes against potentially harmful mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems (Types I, II, III) each recognize and target destruction of foreign invader nucleic acids via structurally and functionally diverse effector complexes (crRNPs). CRISPR-Cas effector complexes are comprised of CRISPR RNAs (crRNAs) that contain sequences homologous to the invading nucleic acids and Cas proteins specific to each immune system type. more...

Organism:

Pyrococcus furiosus

Type:

Non-coding RNA profiling by high throughput sequencing; Other

Platform:

GPL14794

4 Samples

Download data: BEDGRAPH

(Submitter supplied) Analysis of CRISPR RNAs from both total Pyrococcus furiosus RNA and those that co-purify with the Cmr complex, which has been predicted to be involved in RNA-mediated targeting of foreign RNAs in prokaryotes. Small RNAs (20 - 70 nts) were isolated either from total Pyrococcus furiosus RNA or RNAs isolated from immunopurified Cmr complexes. The RNAs were cloned and sequenced using the Illumina platform. more...

Organism:

Pyrococcus furiosus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14794

2 Samples

Download data: BEDGRAPH, SAM

(Submitter supplied) In bacteria and archaea, CRISPR loci confer adaptive, sequence-based immunity against viruses and plasmids. CRISPR interference is specified by CRISPR RNAs (crRNAs) that are transcribed and processed from CRISPR spacers and repeats. Pre-crRNA processing is essential for CRISPR interference in all systems studied thus far. Here we examine crRNA biogenesis and CRISPR interference in naturally competent Neisseria spp., including the human pathogen N. more...

Organism:

Neisseria lactamica 020-06

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16715

2 Samples

Download data: TXT