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Links from GEO DataSets

Items: 20

1.

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

(Submitter supplied) Polycystic ovary Syndrome (PCOS) is a heterogeneous endocrine disorder that shows evidence of genetic predidposition among affected individuals. We have utilized the Microarray data from granulosa cells of normal and PCOS women for network construction.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4399
Platform:
GPL570
10 Samples
Download data: CEL
Series
Accession:
GSE34526
ID:
200034526
2.
Full record GDS4399

Polycystic ovary syndrome: granulosa cells

Analysis of granulosa cells from ovarian aspirates from polycystic ovary syndrome (PCOS) women undergoing in vitro fertilization. PCOS is an endocrine disorder associated with greater risk for infertility, diabetes and cardiovascular diseases. Results provide insight into molecular basis of PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE34526
10 Samples
Download data: CEL
3.

Microarray analysis of NL and PCOS oocytes

(Submitter supplied) Polycystic ovary syndrome (PCOS), the most common cause of anovulatory infertility, is characterized by increased ovarian androgen production, arrested follicle development, and is frequently associated with insulin resistance. These PCOS phenotypes are associated with exaggerated ovarian responsiveness to FSH and increased pregnancy loss. To examine whether the perturbations in follicle growth and the intrafollicular environment affects development of the mature PCOS oocyte, genes that are differentially expressed in PCOS compared to normal oocytes were defined using microarray analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
12 Samples
Download data: CEL, EXP
Series
Accession:
GSE5850
ID:
200005850
4.

Reduced expression of mitochondrial oxidative metabolism genes in skeletal muscle of women with PCOS

(Submitter supplied) Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). Using the HG-U133 Plus 2.0 expression array from Affymetrix, we analyzed gene expression in skeletal muscle from obese women with PCOS (n=16) and age- and body mass index-matched control women (n=13) metabolically characterized by euglycemic-hyperinsulinemic clamp and indirect calorimetry. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3104
Platform:
GPL570
29 Samples
Download data: CEL
Series
Accession:
GSE6798
ID:
200006798
5.
Full record GDS3104

Insulin-resistant polycystic ovary syndrome: muscle

Analysis of vastus lateralis muscles from women with insulin-resistant polycystic ovary syndrome (PCOS). Insulin resistance in skeletal muscles is a risk factor for the development of type 2 diabetes in women with PCOS. Results provide insight into the pathogenesis of insulin resistance in PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE6798
29 Samples
Download data: CEL
DataSet
Accession:
GDS3104
ID:
3104
6.

Profiles for long noncoding RNAs in ovarian granulosa cells from polycystic ovary syndrome patients with different serum concentrations of androgen

(Submitter supplied) Polycystic ovary syndrome (PCOS) is a common reproductive system disease, with hyperandrogenism as the core feature. The pathologies remain to be illustrated. Long noncoding RNAs (lncRNAs) has been proved to be involved in various biological processes of human diseases. However, there were few reports about the research on lncRNAs in PCOS, not to mention hyperandrogenism.
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL21096
12 Samples
Download data: TXT
Series
Accession:
GSE106724
ID:
200106724
7.

Enhanced Inflammatory Transcriptome in the Granulosa Cells of Women With Polycystic Ovarian Syndrome

(Submitter supplied) Context: Polycystic ovarian syndrome (PCOS), the most common endocrine disorder of reproductive- aged women, is associated with systemic low-grade inflammation. Objective: We propose that increased or altered intrafollicular inflammatory reactions also occur in periovulatory follicles of PCOS patients. Design: Gene profiling and quantitative PCR (qPCR) analyses in granulosa-lutein cells (GCs) collected from PCOS and non-PCOS women undergoing in vitro fertilization were compared with serum and follicular fluid (FF) levels of cytokines and chemokines. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE102293
ID:
200102293
8.

PCOS patients vs control subjects

(Submitter supplied) This experiment was designed to study if there are differences in gene expression in the adipose tissue of women affected by polycystic ovary syndrome (PCOS) compared to non-hyperandrogenic women. PCOS is the most common endocrinopathy in women of reproductive age, and is characterized by hyperandrogenism and chronic anovulation. This disease is frequently associated with obesity, insulin resistance, and defects in insulin secretion, predisposing these women to type 2 diabetes, atherosclerosis, and cardiovascular disease. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2084
Platform:
GPL96
17 Samples
Download data: CEL, EXP
Series
Accession:
GSE5090
ID:
200005090
9.
Full record GDS2084

Polycystic ovary syndrome: adipose tissue

Analysis of omental adipose tissues of morbidly obese patients with polycystic ovary syndrome (PCOS). PCOS is a common hormonal disorder among women of reproductive age, and is characterized by hyperandrogenism and chronic anovulation. PCOS is associated with obesity.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL96
Series:
GSE5090
15 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS2084
ID:
2084
10.

Gene expression profiling in skeletal muscle of PCOS after pioglitazone therapy

(Submitter supplied) Insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes. Studies have shown that thiazolidinediones (TZD) improve metabolic disturbances in PCOS patients. We hypothesized that the effect of TZD in PCOS is in part mediated by changes in the transcriptional profile of muscle favoring insulin sensitivity. Using Affymetrix microarrays, we examined the effect of pioglitazone (30 mg/day for 16 weeks) on gene expression in skeletal muscle of 10 obese women with PCOS metabolically characterized by a euglycemic-hyperinsulinemic clamp. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS4132 GDS4133
Platform:
GPL570
43 Samples
Download data: CEL
Series
Accession:
GSE8157
ID:
200008157
11.
Full record GDS4133

Obese women with polycystic ovary syndrome and obese, healthy women: skeletal muscle

Analysis of skeletal muscle from obese women with polycystic ovary syndrome (PCOS) and obese, healthy women. Results provide insight into whether pioglitazone ameliorates preexisting abnormalities in PCOS patients.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE8157
23 Samples
Download data: CEL
12.
Full record GDS4132

PPAR-γ agonist pioglitazone effect on obese women with polycystic ovary syndrome: skeletal muscle

Analysis of skeletal muscle from obese women with polycystic ovary syndrome (PCOS) before and after thiazolidinedione (TZD) pioglitazone treatment. TZDs improve metabolic disturbances in PCOS patients. Results provide insight into the molecular mechanisms underlying the effect of TZD in PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL570
Series:
GSE8157
20 Samples
Download data: CEL
13.

miRNAs expression profile of the cumulus cell samples with PCOS and non-PCOS

(Submitter supplied) To reveal microRNAs expression differences in cumulus cells between polycystic ovary syndrome (PCOS) and non-PCOS women. miRNAs expression profile of the cumulus cell samples with PCOS and non-PCOS were determined by Affymetrix miRNA 2.0.
Organism:
Homo sapiens; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL14613
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE68285
ID:
200068285
14.

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types from Women with Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

(Submitter supplied) Context: Endometrium in polycystic ovary syndrome (PCOS) presents altered gene expression indicating progesterone resistance and predisposing to reduced endometrial receptivity and endometrial cancer. Objective: We hypothesized that an altered endocrine/metabolic environment in PCOS may result in an endometrial “disease phenotype” affecting the gene expression of different endometrial cell populations, including stem cells and their differentiated progeny. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4987
Platform:
GPL6244
29 Samples
Download data: CEL
Series
Accession:
GSE48301
ID:
200048301
15.
Full record GDS4987

Polycystic ovary syndrome: proliferative phase endometrial cell types

Analysis of FACS-sorted endometrial cell types from proliferative phase endometrial biopsies collected from overweight/obese women with PCOS. Results provide insight into the molecular mechanisms underlying an endometrial disease phenotype in women with PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 cell type, 2 disease state sets
Platform:
GPL6244
Series:
GSE48301
29 Samples
Download data: CEL
16.

Cabergoline-treated lutein granulosa cells from polycystic ovarian syndrome (PCOS) patients exhibit higher transcriptomic response than cabergoline-treated controls

(Submitter supplied) This study assessed the transcriptomic profiles of lutein granulosa cells (LGCs) from women with and without PCOS using Affymetrix microarray chips to provide novel information about the molecular changes that occur in these cells when they are treated with a D2-ag (Cb2) and to assess the signal transduction pathways regulated by this treatment. Transcriptomic analysis, using Affimetrix Human 1.0ST. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
16 Samples
Download data: CEL
Series
Accession:
GSE98595
ID:
200098595
17.

Different gene expression profiles of granulosa cells in Chinese obese patients with or without polycystic ovary syndrome

(Submitter supplied) Obese or polycystic ovary syndrome (PCOS) women have encountered poor reproductive outcomes in natural as well as assisted conception. Furthermore, pregnancy complications of women with PCOS are profoundly worsened by obesity. Both obesity and PCOS affect function of granulosa cells, which is essential in offering the oocyte with nutrients and growth regulators.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
16 Samples
Download data: CEL
Series
Accession:
GSE80432
ID:
200080432
18.

Gene expression in rat ovaries treated with DHT

(Submitter supplied) Polycystic ovarian syndrome (PCOS) is an endocrine disorder of the reproductive and metabolic axis in women during the reproductive age. In this study, we used a rat model exhibiting reproductive and metabolic abnormalities similar to human PCOS to unravel the molecular mechanisms underlining this complex syndrome.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
8 Samples
Download data: CEL
Series
Accession:
GSE59456
ID:
200059456
19.

Multiomics analysis reveals molecular abnormalities in granulosa cells of women with polycystic ovary syndrome

(Submitter supplied) Polycystic ovary syndrome (PCOS) is the most common complex endocrine and metabolic disease in women of reproductive age. It is characterized by anovulatory infertility, hormone disorders, and polycystic ovarian morphology. Regarding the importance of granulosa cells (GCs) in the pathogenesis of PCOS, few studies have investigated the etiology at a single “omics” level, such as with an mRNA expression array or methylation profiling assay, but this can provide only limited insights into the biological mechanisms. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL16791
40 Samples
Download data: TXT
Series
Accession:
GSE168404
ID:
200168404
20.

Epigenetic reprogramming of immune cells in women with PCOS impact genes controlling reproductive function

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL18573
41 Samples
Download data: COV
Series
Accession:
GSE130582
ID:
200130582
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