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Links from GEO DataSets

Items: 20

1.

MiRNA expression profile in murine

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
28 Samples
Download data
Series
Accession:
GSE34648
ID:
200034648
2.

MiRNA expression profile in murine advanced atherosclerotic plaque compared with early atherosclerotic plaque

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
7 Samples
Download data: XLSX
Series
Accession:
GSE34647
ID:
200034647
3.

MiRNA expression profile in murine un-diseased arterial tissue on 3 month high fat diet vs 10 month high fat diet

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
7 Samples
Download data: XLSX
Series
Accession:
GSE34646
ID:
200034646
4.

MiRNA expression profile in murine early atherosclerotic plaque compared with un-diseased arterial tissue

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
8 Samples
Download data: XLSX
Series
Accession:
GSE34645
ID:
200034645
5.

MiRNA expression profile in murine advanced atherosclerotic plaque compared with un-diseased arterial wall

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
6 Samples
Download data: XLSX
Series
Accession:
GSE34644
ID:
200034644
6.

MiRNA expression profile in the aortas of Apoe-/- mice with an specific knock-out of Dicer in endothelial cells compared to control mice after 4 weeks of a high-fat diet

(Submitter supplied) Increased monocyte adhesion to dysfunctional endothelial cells (ECs) orchestrated by chemokines plays an important role in arterial inflammation during atherosclerosis. Endothelial microRNAs (miRNAs) processed by the RNase Dicer1 determine the phenotype of ECs by posttranscriptional regulation of gene expression. However, the impact of endothelial miRNAs on endothelial inflammation and atherosclerosis is currently unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL18082
6 Samples
Download data: TXT
Series
Accession:
GSE53435
ID:
200053435
7.

MiRNA profiling in aortas of Apoe-/- mice with an specific knock-out of Dicer in endothelial cells compared to control mice after 12 weeks of a high-fat diet

(Submitter supplied) Increased monocyte adhesion to dysfunctional endothelial cells (ECs) orchestrated by chemokines plays an important role in arterial inflammation during atherosclerosis. Endothelial microRNAs (miRNAs) processed by the RNase Dicer1 determine the phenotype of ECs by posttranscriptional regulation of gene expression. However, the impact of endothelial miRNAs on endothelial inflammation and atherosclerosis is currently unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL18082
6 Samples
Download data: TXT
Series
Accession:
GSE53433
ID:
200053433
8.

MiR expression profiles in M1-polarized compared with unstimulated (MФ) bone marrow-derived macrophage cells

(Submitter supplied) The global change of the miR expression profile during atherosclerosis is due to the infiltration of different types of leukocytes into the arterial vessel wall in addition to disease-specific regulation in vascular cells. Monocyte-derived macrophage accumulation in the subintimal region is critical in the formation of atherosclerotic plaques. It is currently unknown which miRs are involved in the atherogenic macrophage response. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15673
10 Samples
Download data: TXT
Series
Accession:
GSE33453
ID:
200033453
9.

Changes in miR expression profile carotid plaques induced by acutely induced flow disturbances in apoe-/- mice on a high fat diet.

(Submitter supplied) Atherosclerosis is causally related to disturbed flow through low and oscillatory shear stress. In order to study the miR expression profile in atherosclerotic plaques induced by disturbed flow, partial ligation of the carotid artery was performed. This procedure results acutely in severly reduced blood flow and in stenotic lesion formation within 6 weeks in apoe-/- mice on a high fat diet. We compared the miR expression profile in partially ligated left carotid arteries with the untreated right carotid artery to identify miRs which are involved in plaque formation through flow disturbances.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL11419
12 Samples
Download data: TXT
Series
Accession:
GSE26555
ID:
200026555
10.

Expression profiling of Dicer loss-of-function macrophages

(Submitter supplied) The role of microRNAs in the inflammatory response of macrophages to LPS was adressed by expression analysis in DicerKO (LysMcre/+;Dicerfl/fl;ApoE-/-) vs wildtype (LysMcre/+;Dicer+/+ApoE-/-) macrophages when challenged either with vehicle (PBS) or LPS.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
12 Samples
Download data: TXT
Series
Accession:
GSE106854
ID:
200106854
11.

Ago2-RIP-chip and miRNA expression profile in Dicer WT and KO macrophages from bone marrow or aorta

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR; Other
Platforms:
GPL15053 GPL13912 GPL18082
18 Samples
Download data: TXT
Series
Accession:
GSE87721
ID:
200087721
12.

miRNA expression profile in aortas from LysM-Cre/Dicerflox/flox/Apoe–/– mice compared with LysM-Cre/Dicerwt/wt/Apoe–/– mice fed with high-fat diet for 12 weeks

(Submitter supplied) The global change of the miRNA expression profile during atherosclerosis is due to the infiltration of different types of leukocytes into the arterial vessel wall in addition to disease-specific regulation in vascular cells. Monocyte-derived macrophage accumulation in the subintimal region is critical in the formation of atherosclerotic plaques. However, the role of Dicer, the key enzyme for miRNA biogenesis, during the development of atherosclerosis is currently unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
6 Samples
Download data: TXT
Series
Accession:
GSE87719
ID:
200087719
13.

miRNA expression profiles in Dicer WT and KO bone marrow-derived macrophages

(Submitter supplied) The global change of the miRNA expression profile during atherosclerosis is due to the infiltration of different types of leukocytes into the arterial vessel wall in addition to disease-specific regulation in vascular cells. Monocyte-derived macrophage accumulation in the subintimal region is critical in the formation of atherosclerotic plaques. However, the role of Dicer, the key enzyme for miRNA biogenesis, during the development of atherosclerosis is currently unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL18082
6 Samples
Download data: TXT
Series
Accession:
GSE87718
ID:
200087718
14.

Ago2-RIP-chip in Dicer WT and KO macrophages

(Submitter supplied) To determine the spectrum of miRNA targets regulated following Dicer deletion, we performed argonaute 2 (AGO2)-RNA Immunoprecipitation (RIP)-microarray in bone marrow-derived macrophages (BMDMs) from LysM-Cre/Dicerflox/flox/Apoe–/– and LysM-Cre/Dicerwt/wt/Apoe–/– mice. This analysis combined with miRNA profiling in Dicer wild type (WT) and knockout (KO) BMDMs may help to identify the miRNA targets regulated by Dicer deletion.
Organism:
Mus musculus
Type:
Other
Platform:
GPL13912
6 Samples
Download data: TXT
Series
Accession:
GSE87717
ID:
200087717
15.

Attenuation of early atherogenesis in LDLR-KO mice by proteasome inhibition

(Submitter supplied) To get further insights into the processes leading to attenuation of early stage atherosclerosis in the bortezomib treated LDLR-KO mice, microarray profiling of gene expression was performed on RNA taken from whole aortae of bortezomib treated LDLR-KO and sham- treated LDLR-KO mice fed a Western diet for 6 weeks and compared the changes in gene expression in both groups to non-atherosclerotic CD animals.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
6 Samples
Download data: TXT
Series
Accession:
GSE30638
ID:
200030638
16.

Regulation of Activation-Associated mRNA and MicroRNA Accumulation Rates during Monocyte-to-Macrophage Differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platforms:
GPL19055 GPL14851
57 Samples
Download data
Series
Accession:
GSE60550
ID:
200060550
17.

Regulation of Activation-Associated Transcripts Accumulation Rates during Monocyte-to-Macrophage Differentiation

(Submitter supplied) We profiled macrophage activation-associated transcripts using TaqMan assays in a Fluidigm 48.48 Gene Expression Array to identify transcripts with expression levels that were affected by differences in culturing conditions during monocyte-to-macrophage differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL19055
48 Samples
Download data: TXT, XLS
Series
Accession:
GSE60549
ID:
200060549
18.

Regulation of Activation-Associated MicroRNA Accumulation Rates during Monocyte-to-Macrophage Differentiation

(Submitter supplied) We profiled miRNA expression using TaqMan TLDA assays to identify miRNAs with expression levels that were affected by differences in culturing conditions during monocyte-to-macrophage differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL14851
9 Samples
Download data: TXT
Series
Accession:
GSE60110
ID:
200060110
19.

Gene expression profiles of DKO172 cells expressing DICER1 wildtype or hotspot mutants

(Submitter supplied) DICER1 plays a critical role in microRNA (miRNA) biogenesis. Recurrent somatic “hotspot” mutations at four mental binding sites within the RNase IIIb domain of DICER1, were identified in ovarian sex cord-stromal tumors and have since been described in other pediatric tumors. In this study, we identified and characterized DICER1 hotspot mutations in endometrial cancers derived from The Cancer Genome Atlas (TCGA) and our local tumor bank. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
12 Samples
Download data: TXT
Series
Accession:
GSE65092
ID:
200065092
20.

MicroRNA expression in thioglycollate and alternatively activated

(Submitter supplied) Macrophage activation must be tightly controlled to prevent overzealous responses that cause self-damage. MicroRNAs have been shown to promote classical macrophage activation by blocking concomitant anti-inflammatory signals and transcription factors, but can also place restraints on activation by preventing excessive TLR-signalling. In contrast, the microRNA profile associated with alternatively activated macrophages and their role in regulating wound-healing or anti-helminthic responses has not yet been described. more...
Organism:
Human alphaherpesvirus 1; Macaca mulatta polyomavirus 1; Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL15121
14 Samples
Download data: TXT
Series
Accession:
GSE35047
ID:
200035047
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