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Links from GEO DataSets

Items: 20

1.

MicroRNA expression in thioglycollate and alternatively activated

(Submitter supplied) Macrophage activation must be tightly controlled to prevent overzealous responses that cause self-damage. MicroRNAs have been shown to promote classical macrophage activation by blocking concomitant anti-inflammatory signals and transcription factors, but can also place restraints on activation by preventing excessive TLR-signalling. In contrast, the microRNA profile associated with alternatively activated macrophages and their role in regulating wound-healing or anti-helminthic responses has not yet been described. more...
Organism:
Human alphaherpesvirus 1; Macaca mulatta polyomavirus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL15121
14 Samples
Download data: TXT
Series
Accession:
GSE35047
ID:
200035047
2.

Experimental identification of miR-378-3p targets by overexpression and silencing in murine NIH-3T3 fibroblasts

(Submitter supplied) MicroRNAs (miRNAs) are short noncoding RNA molecules regulating the expression of mRNAs. Target identification of miRNAs is computationally difficult due to the relatively low homology between miRNAs and their targets. We provide data here utilizing an experimental approach to identify targets of mmu-miR-378-3p, where mmu-miR-378-3p was overexpressed and silenced in NIH-3T3 murine fibroblasts and compared to control RNA transfected cells (RISC-free siRNA). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
9 Samples
Download data: CEL
Series
Accession:
GSE34873
ID:
200034873
3.

The IL4-STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
synthetic construct; Mus musculus; Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL6246 GPL8786
21 Samples
Download data: CEL, CHP
Series
Accession:
GSE71644
ID:
200071644
4.

Negative control and mir-342-3p mimics-transfected RAW264.7 mouse macrophages.

(Submitter supplied) RAW264.7 mouse macrophages were transfected with negative control and miR-342-3p mimics and subjected to microarray analysis 18 hours after the transfection. We used microarray to obtain global mRNA expression data of negative control and miR-342-3p mimics-transfected RAW264.7 cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE71642
ID:
200071642
5.

Human periheral blood-derived monocytes and unstimulated as well as IL-4-stimulated differentiating macrophages

(Submitter supplied) CD14+ monocytes were separated from human peripheral blood and exposed to IL-4 for 12 or 72 hours then subjected to microarray analysis We used Affymetrix miRNA1.0 microarray to obtain global miRNA expression data of human monocytes, unstimulated and IL-4-stimulated differentiating macrophages.
Organism:
Homo sapiens; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL8786
15 Samples
Download data: CEL, CSV
Series
Accession:
GSE71641
ID:
200071641
6.

MiRNA expression profile in murine

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
28 Samples
Download data
Series
Accession:
GSE34648
ID:
200034648
7.

MiRNA expression profile in murine advanced atherosclerotic plaque compared with early atherosclerotic plaque

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
7 Samples
Download data: XLSX
Series
Accession:
GSE34647
ID:
200034647
8.

MiRNA expression profile in murine un-diseased arterial tissue on 3 month high fat diet vs 10 month high fat diet

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
7 Samples
Download data: XLSX
Series
Accession:
GSE34646
ID:
200034646
9.

MiRNA expression profile in murine early atherosclerotic plaque compared with un-diseased arterial tissue

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
8 Samples
Download data: XLSX
Series
Accession:
GSE34645
ID:
200034645
10.

MiRNA expression profile in murine advanced atherosclerotic plaque compared with un-diseased arterial wall

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
6 Samples
Download data: XLSX
Series
Accession:
GSE34644
ID:
200034644
11.

WTX overexpression effect on gastric cell line

(Submitter supplied) We used microarrays to detail the global gene expression in AGS gastric cancer cells overexpressing WTX, a tumor suppressor frequently inactivated in Wilms tumor. Results provide insight into roles for WTX in gastric cancer cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
2 Samples
Download data: CEL
Series
Accession:
GSE114353
ID:
200114353
12.

Interferon gamma down-regulates miR-3473b to promote macrophage activation

(Submitter supplied) Macrophages are major effector cells and antigen presenting cells of the innate immune system and classical activation of macrophage function requires interferon–γ (IFN-γ) pretreatment (priming) and TLR stimuli, which promotes inflammatory responses though high levels of pro-inflammatory cytokines and lower level of the anti-inflammatory cytokines, resulting in microbicidal and tumoricidal effect. However, the underlying molecular mechanism of IFN-γ priming remains elusive. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL15216
1 Sample
Download data: XLS
Series
Accession:
GSE50569
ID:
200050569
13.

miRNA arrays for LPS-activated Akt1+/+ and Akt1-/- macrophages

(Submitter supplied) MicroRNAs regulated by lipopolysaccharide (LPS) target genes that contribute to the inflammatory phenotype. Here we showed that the protein kinase Akt1, which is activated by LPS, positively regulated miRNAs let-7e, miR-181c but negatively regulated miR-155 and miR-125b. In silico analyses and transfection studies revealed that let-7e repressed Toll-like receptor 4 (TLR4) whereas miR-155 repressed SOCS1, two proteins critical for LPS-driven TLR signalling, which regulate endotoxin sensitivity and tolerance. more...
Organism:
Homo sapiens; Rattus norvegicus; Mus musculus
Type:
Other
Platform:
GPL8952
4 Samples
Download data
Series
Accession:
GSE17421
ID:
200017421
14.

miRCURY LNATM microRNA Array (7th Gen) profiling of monocyte-derived macrophages and monocyte-derived dendritic cells.

(Submitter supplied) To examine the miRNA changes that occur during macrophage and dendritic cell differentiation we used the miRCURY LNATM microRNA Array (7th Gen) to profile monocyte-derived macrophages and monocyte-derived dendritic cells. Of the 2046 probes present on the assay, we detected expression of ~400 (20%) miRNAs across all samples.
Organism:
Cytomegalovirus; Human polyomavirus 1; Human alphaherpesvirus 2; Lymphocryptovirus; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Homo sapiens; Human alphaherpesvirus 1; Rhadinovirus; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL19128
90 Samples
Download data: TXT, XLSX
Series
Accession:
GSE60839
ID:
200060839
15.

miR-221-3p drives the Shift of M2-Macrophage to a Pro-Inflammatory Function by Modulating JAK3/STAT3 Signaling and is Increased in Rheumatoid Arthritis

(Submitter supplied) We performed a transcriptome analysis of M2 macrophages generated in vitro from monocytes isolated from peripheral blood of healthy donors, and studied the effect of miR-221-3p mimic transfection and stimulation with LPS.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
20 Samples
Download data: TSV
Series
Accession:
GSE133527
ID:
200133527
16.

The differential miRNA expression induces M2 macrophage polarization and mediates their profibrogenic effects

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; synthetic construct
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL13497 GPL17107
21 Samples
Download data: TXT
Series
Accession:
GSE59349
ID:
200059349
17.

M2 cytokines alter the miRNA expression profile in macrophages

(Submitter supplied) To examine the miRNA expression profile of the profibrogenic macrophages, we compared miRNA expression in untreated versus IL-4 or IL-13-treated macrophages using miRNA microarray.IL-4 and IL-13 treatment resulted in marked changes in 18 and 19 miRNAs in macrophages, respectively.(n=3, fold changes>2, P<0.05)
Organism:
Homo sapiens; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL17107
9 Samples
Download data: TXT
Series
Accession:
GSE59348
ID:
200059348
18.

mRNA expression profile in IL-4-treated macrophages transfected with miR-142-5p ASO or miR-130a-3p mimics

(Submitter supplied) To identify target genes of miR-142-5p and miR-130a-3p that are involved in M2 polarization, we examined the mRNA expression profile changes after altering miR-142-5p or miR-130a-3p expression in IL-4-treated macrophages.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13497
12 Samples
Download data: TXT
Series
Accession:
GSE59347
ID:
200059347
19.

Genome-wide analysis of gene expression of livers of wild type and IL-4/IL-13-/- mice after carbon tetrachloride-induced injury

(Submitter supplied) Global analysis of differentially expressed genes of livers of wild type and IL-4/IL-13-/- two days after carbon tetrachloride treatment.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5073
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE45002
ID:
200045002
20.
Full record GDS5073

IL-4 IL-13 double mutant liver response to acute injury

Analysis of livers of IL-4 IL-13 double mutants 2 days following treatment with carbon tetracholoride to induce acute liver injury. Results provide insight into the role of IL-4 and IL-13 in liver regeneration.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation sets
Platform:
GPL6885
Series:
GSE45002
8 Samples
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