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Links from GEO DataSets

Items: 20

1.

Genome-wide analysis of mouse macrophages stimulated with IL-4 (bone marrow macrophages) (Affymetrix)

(Submitter supplied) Analysis of alternative activation of macrophages at gene expression level. The study forms part of a wider study where we compare the effects of IL-4 in different human and mouse macrophages. Our results support the notion that in vitro culture conditions greatly affect the macrophage response to IL-4. Total RNA obtained from bone marrow derived macrophages upon exposure to 20 ng/ml of IL-4 for 18 hours.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE35435
ID:
200035435
2.

Similarities and differences between human activated macrophages II

(Submitter supplied) We compare, in human macrophages, stimuli considered to induce M1 or M2 type of activation, also termed classical and alternative activation. This dataset highlights key differences between the M1 and M2 stimuli pointing to the need of a revision of the paradigm. Macrophages were left untreated or stimulated with IL-4 and IL-13 (prototypic M1 stimuli), Dexamethasone (Glucocorticoid receptor agonist) which has been hitherto considered M2, IL-10 which also falls under the M2 umbrella, and LPS and Interferon Gamma considered M1 stimuli. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
7 Samples
Download data: TXT
Series
Accession:
GSE51446
ID:
200051446
3.

Similarities and differences between human activated macrophages I

(Submitter supplied) The human AA dataset 5 includes the gene expression profile of monocyte-derived macrophages isolated from blood donor buffy coats and plated on TCP in medium containing 10% autologous serum. Cells were stimulated for 120 hours with 50 ng/ml of IL-4, 50 U/ml of IFN-γ plus 12.5 ng/ml of TNF-α, 50 ng/ml of M-CSF or 50 ng/ml of IL-10. RNA samples were isolated using TriPure isolation reagent (Roche) and the RNeasy Mini Kit-Qiagen Clean up method. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE49240
ID:
200049240
4.

Genome-wide analysis of human and mouse macrophages, resting and activated

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
5 related Platforms
73 Samples
Download data: CEL
Series
Accession:
GSE35495
ID:
200035495
5.

Genome-wide analysis of mouse macrophages stimulated with IL-4 (Biogel and thioglycollate macrophages) (Affymetrix)

(Submitter supplied) Analysis of alternative activation of macrophages at gene expression level. The study forms part of a wider study where we compare the effects of IL-4 in different human and mouse macrophages. Our results support the notion that in vitro culture conditions greatly affect the macrophage response to IL-4. Total RNA obtained from Thioglycollate and Biogel elicited peritoneal macrophages exposed to 20 ng/ml of IL-4 for 18 hours.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE35436
ID:
200035436
6.

Genome-wide analysis of human macrophages stimulated with IL-4 (10ng/ml) (Illumina)

(Submitter supplied) Analysis of alternative activation of macrophages at gene expression level. The study forms part of a wider study where we compare the effects of IL-4 in different human and mouse macrophages. Our results support the notion that in vitro culture conditions greatly affect the macrophage response to IL-4.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
6 Samples
Download data: TXT
Series
Accession:
GSE35434
ID:
200035434
7.

Genome-wide analysis of human macrophages stimulated with IL-4 (20ng/ml) (Illumina)

(Submitter supplied) Analysis of alternative activation of macrophages at gene expression level. The study forms part of a wider study where we compare the effects of IL-4 in different human and mouse macrophages. Our results support the notion that in vitro culture conditions greatly affect the macrophage response to IL-4.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
6 Samples
Download data: TXT
Series
Accession:
GSE35433
ID:
200035433
8.

RNA-seq of human peripheral blood mononuclear cells

(Submitter supplied) Inflammatory cytokine responses to activation of innate immunity differ between individuals, yet the genomic and transcriptomic determinants of inflammatory responsiveness are not well understood. We hypothesized that mRNA and lincRNA expression is modulated in disease-relevant tissues in humans in vivo during inflammation, and differs between individuals with divergent evoked inflammatory responses. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
30 Samples
Download data: DIFF
Series
Accession:
GSE87290
ID:
200087290
9.

Expression Data from Macrophage Maturation and Polarization Experiment

(Submitter supplied) Monocytes were induced to mature to macrophages with M-CSF. Cells were then activated with Interferon gamma and LPS or IL-4.
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2429 GDS2430
Platforms:
GPL97 GPL96
30 Samples
Download data: CEL
Series
Accession:
GSE5099
ID:
200005099
10.
Full record GDS2430

Monocyte differentiation to macrophage and subsequent polarization (HG-U133B)

Analysis of monocytes (MCs) treated with M-CSF to induce differentiation into macrophages (MPs), and mature MPs treated with either IFN-gamma and LPS or IL-4 to induce polarization to M1 or M2 cells, respectively. Results provide insight into MC to MP differentiation and polarized activation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 development stage sets
Platform:
GPL97
Series:
GSE5099
15 Samples
Download data: CEL
DataSet
Accession:
GDS2430
ID:
2430
11.
Full record GDS2429

Monocyte differentiation to macrophage and subsequent polarization (HG-U133A)

Analysis of monocytes (MCs) treated with M-CSF to induce differentiation into macrophages (MPs), and mature MPs treated with either IFN-gamma and LPS or IL-4 to induce polarization to M1 or M2 cells, respectively. Results provide insight into MC to MP differentiation and polarized activation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 development stage sets
Platform:
GPL96
Series:
GSE5099
15 Samples
Download data: CEL
DataSet
Accession:
GDS2429
ID:
2429
12.

Effects of TGF-beta on mature macrophages

(Submitter supplied) The goal of the study was to identify the effects of TGF-beta on primary human macrophages maturated under different conditions. Keywords: time course, differentiation conditions, alternative activation
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
25 Samples
Download data: CEL, CHP
Series
Accession:
GSE7568
ID:
200007568
13.

Control of the inflammatory macrophage transcriptional signature by miR-155

(Submitter supplied) Classically activated (M1) macrophages protect from infection but can cause inflammatory disease and tissue damage while alternatively activated (M2) macrophages reduce inflammation and promote tissue repair. Modulation of macrophage phenotype may be therapeutically beneficial and requires further understanding of the molecular programs that control macrophage differentiation. A potential mechanism by which macrophages differentiate may be through microRNA (miRNA), which bind to messenger RNA and post-transcriptionally modify gene expression, cell phenotype and function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL, XLSX
Series
Accession:
GSE77425
ID:
200077425
14.

The IL4-STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus; synthetic construct
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL6246 GPL8786
21 Samples
Download data: CEL, CHP
Series
Accession:
GSE71644
ID:
200071644
15.

Negative control and mir-342-3p mimics-transfected RAW264.7 mouse macrophages.

(Submitter supplied) RAW264.7 mouse macrophages were transfected with negative control and miR-342-3p mimics and subjected to microarray analysis 18 hours after the transfection. We used microarray to obtain global mRNA expression data of negative control and miR-342-3p mimics-transfected RAW264.7 cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE71642
ID:
200071642
16.

Human periheral blood-derived monocytes and unstimulated as well as IL-4-stimulated differentiating macrophages

(Submitter supplied) CD14+ monocytes were separated from human peripheral blood and exposed to IL-4 for 12 or 72 hours then subjected to microarray analysis We used Affymetrix miRNA1.0 microarray to obtain global miRNA expression data of human monocytes, unstimulated and IL-4-stimulated differentiating macrophages.
Organism:
synthetic construct; Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8786
15 Samples
Download data: CEL, CSV
Series
Accession:
GSE71641
ID:
200071641
17.

Novel transcriptome signatures and markers defining murine macrophages at the extremes of the canonical M1 and M2 polarization spectrum

(Submitter supplied) Classically (M1) and alternatively activated (M2) macrophages play distinct roles in various physiological and disease processes. Understanding the gene transcription programs that contribute to macrophage polarization along the M1/M2 spectrum may lead to new tools to detect and therapeutically manipulate macrophage phenotype. Here, we define the M1 and M2 macrophage signature through mRNA microarray. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE69607
ID:
200069607
18.

Functional and Transcriptomic Characterization of iPSC-derived Macrophages and their Application in Modeling Mendelian Disease

(Submitter supplied) Using RNA-Seq, we reported novel findings in the comparison of transcriptome profiles of isogenic HMDM and IPSDM during differentiation and polarization. First, IPSDM lost expression of pluripotency markers, had remarkably distinct gene expression profiles relative to precursor iPSCs, and had largely similar gene expression as HMDM. Second, macrophage polarization to M1 was associated with a dramatic change in the transcriptome; expression profiles of IPSDM- and HMDM-derived M1 lines were highly correlated with each other but much less so with their respective IPSDM and HMDM precursors. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
33 Samples
Download data: DIFF, TXT
Series
Accession:
GSE55536
ID:
200055536
19.

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to PGE2

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
34 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE119521
ID:
200119521
20.

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to PGE2 (RNA-seq)

(Submitter supplied) Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here we show that PGE2 causes mitochondrial membrane potential (Δψm) to dissipate in interleukin-4 activated macrophages (M(IL-4)). Effects on Δψm are a consequence of PGE2-initiated transcriptional regulation of genes in the malate-aspartate shuttle (MAS), particularly GOT1. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
30 Samples
Download data: TXT
Series
Accession:
GSE119509
ID:
200119509
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