GEO DataSets

(Submitter supplied) RNA expression patterns of liver cell lines were compared to those of liver tumors to determine the suitability of cell lines as a model for drug development studies. The cell lines appear to recapitulate liver tumors.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

20 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling was conducted on RNA from 23 breast cancer cell lines to identify genes whose expression level correlates with sensitivity of particular drug Keywords: comparison of sensitive group versus resistant group of cell lines to particular drug

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

46 Samples

Download data

(Submitter supplied) HER2 targeting with trastuzumab has changed the prognosis of breast cancer patients carrying amplification and/or overexpression of this oncogene. Despite this progress, however, resistance to trastuzumab occurs in the vast majority of patients. Newer anti-HER2 therapies, like the dual tyrosine-kinase inhibitor (TKI) lapatinib, show antitumor activity in a limited proportion of patients, indicating that HER2 can be still exploited as a target after trastuzumab failure. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

2 Samples

Download data: TXT

(Submitter supplied) Epithelial-mesenchymal transition (EMT), a switch of polarized epithelial cells to a migratory, fibroblastoid phenotype, is considered a key process driving tumor cell invasiveness and metastasis. Using breast cancer cell lines as a model system, we sought to discover gene-expression signatures of EMT with clinical and mechanistic relevance. A supervised comparison of epithelial and mesenchymal breast cancer lines defined a 200-gene EMT signature that was prognostic across multiple breast cancer cohorts. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL7785

20 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL10558 GPL21185

20 Samples

Download data: IDAT, TXT

(Submitter supplied) Abstract. Background: Glioblastoma is the most common primary malignancy of the central nervous system with dismal prognosis. Differential gene expression classifies IDH-wildtype glioblastoma into three subtypes: proneural, mesenchymal and classical. Dasatinib, an inhibitor of the proto-oncogene tyrosine-protein kinase SRC, is one of many therapeutics that, despite promising preclinical results, has failed to improve overall survival in glioblastoma patients in clinical trials. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

9 Samples

Download data: IDAT, TXT

(Submitter supplied) Abstract. Background: Glioblastoma is the most common primary malignancy of the central nervous system with dismal prognosis. Differential gene expression classifies IDH-wildtype glioblastoma into three subtypes: proneural, mesenchymal and classical. Dasatinib, an inhibitor of the proto-oncogene tyrosine-protein kinase SRC, is one of many therapeutics that, despite promising preclinical results, has failed to improve overall survival in glioblastoma patients in clinical trials. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL21185

11 Samples

Download data: TXT

(Submitter supplied) Gene profiles from three dasatinib-resistant and three dasatinib-sensitive pancreatic cancer cell lines were compared by microarray analysis.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5627

Platform:

GPL10558

18 Samples

Download data: TXT

Analysis of dasatinib-resistant and dasatinib-sensitive PC cell lines. Dasatinib, a small-molecule kinase inhibitor, is FDA-approved for PC, but certain PC cells can have intrinsic or acquired resistance to dasatinib. Results provide insight into molecular basis of dasatinib-resistance in PC cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 6 cell line, 2 cell type sets

Platform:

GPL10558

Series:

GSE59357

18 Samples

Download data

(Submitter supplied) Transcriptional profiling was conducted on RNA from 16 prostatic cancer cell lines to identify genes whose expression level correlate with sensitivity of an anti-tumor agent (dasatinib). Keywords: comparison of sensitive group versus resistant group of cell lines to agent

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3155

Platform:

GPL571

16 Samples

Download data: CEL

Analysis of 16 prostatic cancer cell lines treated with anti-tumor agent dasatinib. The cell lines display sensitivity or resistance to dasatinib. Results used to define a gene expression profile associated with sensitivity to dasatinib.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 16 cell line, 2 other sets

Platform:

GPL571

Series:

GSE9633

16 Samples

Download data: CEL

(Submitter supplied) Transforming Growth Factor beta (TGF-beta) is a pleiotropic cytokine playing a key role in liver carcinogenesis. The goal of this study was to identify genes differentially expressed in hepatocellular carcinoma cell lines PRC/PRF/5 and SNU-449 after a treatment with TGF-beta and/or Galunisertib, an inhibitor of the type I TGF-beta receptor (TGFBRI). Thus, cells were treated for 16 hours with 1 ng/mL recombinant human TGF-β1 (R&D Systems, Minneapolis, MN) and/or 10 μM LY2157299 (Sigma-Aldrich, St. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL21185

24 Samples

Download data: TXT