GEO DataSets

(Submitter supplied) Mammalian females are born with a finite number of non-renewing primordial follicles, the majority of which remain in a quiescent state for many years. Due to their non-renewing nature, these resting oocytes are particularly vulnerable to xenobiotic insult, resulting in premature ovarian senescence and the formation of dysfunctional oocytes. In this study we characterised the mechanisms of ovotoxicity for the ovotoxic agent 3-methylcholanthrene (3MC), which targets immature follicles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

6 Samples

Download data: TXT, XLSX

(Submitter supplied) Mammalian females are born with a finite number of non-renewing primordial follicles, the majority of which remain in a quiescent state for many years. Due to their non-renewing nature, these “resting” oocytes are particularly vulnerable to xenobiotic insult, resulting in premature ovarian senescence and the formation of dysfunctional oocytes. In this study we characterised the mechanisms of ovotoxicity for the ovotoxic agent 7,12-dimethylbenz-[a]anthracene (DMBA), which targets immature follicles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

9 Samples

Download data: TXT, XLSX

(Submitter supplied) Mammalian females are born with a finite number of non-renewing primordial follicles, the majority of which remain in a quiescent state for many years. Due to their non-renewing nature, these “resting” oocytes are particularly vulnerable to xenobiotic insult, resulting in premature ovarian senescence and the formation of dysfunctional oocytes. In this study we characterised the mechanisms of ovotoxicity for three ovotoxic agents, 4-Vinylcyclohexene Diepoxide (VCD), Methoxychlor (MXC), and Menadione (MEN), all of which target immature follicles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4171

Platform:

GPL1261

12 Samples

Download data: CEL, XLS

Analysis of ovaries from Swiss neonates cultured in media containing xenobiotics: 4-vinylcyclohexene diepoxide, methoxychlor, menadione. Non-renewing follicles are vulnerable to xenobiotic insult. Results provide insight into molecular mechanisms underlying xenobiotic-induced preantral ovotoxicity.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 agent sets

Platform:

GPL1261

Series:

GSE23725

12 Samples

Download data: CEL

(Submitter supplied) Women are born with millions of primordial follicles which gradually decrease with increasing age and this irreversible supply of follicles completely exhausts at menopause. The fertility capacity of women diminishes in parallel with aging. The mechanisms for reproductive aging are not fully understood. In our recent work we observed a decline in BRCA1 mediated DNA repair in aging rat primordial follicles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

6 Samples

Download data: TXT