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Links from GEO DataSets

Items: 8

1.

Hypoxia-induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling

(Submitter supplied) Hypoxia (low oxygen) and Notch signaling are two important regulators of vascular development, but how they interact in controlling the choice between arterial and venous fates for endothelial cells during vasculogenesis is less well understood. In this report, we show that hypoxia and Notch signaling intersect in promotion of arterial differentiation. Hypoxia upregulated expression of the Notch ligand Dll4 and increases Notch signaling, in a process requiring the vasoactive hormone adrenomedullin but not endogenous VEGF. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
12 Samples
Download data: TXT
Series
Accession:
GSE35894
ID:
200035894
2.

Expression profiling after ICAP1 or constitutive active NOTCH1 over expression in human umbilical vein endothelial cells

(Submitter supplied) ICAP1 (also known as ITG1BP1) is a protein interaction partner of beta1-integrins and the cerebral cavernous malformation protein 1 (CCM1, also known as KRIT1). In mice Icap1 plays an important role for bone development. The function of ICAP1 in endothelial cells is poorly understood. However, the interactions with beta1-integrins and CCM1 suggest that ICAP1 should play an important role also in endothelial cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
6 Samples
Download data: TXT
Series
Accession:
GSE18035
ID:
200018035
3.

Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade

(Submitter supplied) Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryonic angiogenesis, but its role in coronary development remains uncertain. We show Jag1, Dll4 and activated Notch1 receptor expression in sinus venosus (SV) endocardium. Endocardial Jag1 removal blocks SV capillary sprouting, while Dll4 inactivation stimulates excessive capillary growth, suggesting that ligand antagonism regulates coronary primary plexus formation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
36 Samples
Download data: XLS
Series
Accession:
GSE110614
ID:
200110614
4.

Expression analysis of mouse retinas after treatment with VEGF-A or Dll4-Fc.

(Submitter supplied) Transcriptional profiling of retinas extracted from mouse pups 24 hours after IVT injection (at P8) of 1 microgram VEGFA, 4 micrograms Dll4-Fc, or 4 microgram hFc alone. Goal was to determine the mechanism by which inhibiting Dll4/Notch pathway is vasoprotective during retinal development.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13397
16 Samples
Download data: TXT
Series
Accession:
GSE28516
ID:
200028516
5.

Gene expression profile of DLL4+ and DLL4- Hemato-Endothelial Progenitors (HEPs) subpopulations

(Submitter supplied) In hESCs, expression of the Notch ligand DLL4 parallels the emergence of bipotent hematoendothelial progenitors (HEPs) and promotes their hematopoietic differentiation. During differentiation, DLL4 is only expressed in a subpopulation of HEPs. To study the developmental fate of the two subpopulations of HEPs identified by DLL4 expression, we FACS-isolated DLL4high and DLL4low/- HEPs at day 15 of differentiation and performed gene expression analysis using microarrays
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13607
4 Samples
Download data: TXT
Series
Accession:
GSE56881
ID:
200056881
6.

Expression data from WT and Snail1 knockout (KO) embryonic endothelial cells (ECs)

(Submitter supplied) Snail1 is a master factor of epithelial to mesenchymal transitioin (EMT), however, its role in embryonic vascular development is largely undefined. We used microarrays to compare the global programme of gene expression between cultured WT and Snai1 KO embyronic ECs.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
2 Samples
Download data: CEL
Series
Accession:
GSE57030
ID:
200057030
7.

Integration between Notch- and hypoxia-induced transcriptomes

(Submitter supplied) Background: Interaction between key signaling mechanisms is important to generate the diversity in signaling output required for proper control of cellular differentiation and function, although the molecular manifestations of such cross-talk are only partially understood. Notch signaling and the cellular response to hypoxia intersect at different points in the signaling cascades, and in this report we analyze the consequences of this cross-talk at the transcriptome level. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
30 Samples
Download data: TXT
Series
Accession:
GSE19074
ID:
200019074
8.

Arterialization requires the timely suppression of cell growth

(Submitter supplied) Arteries are thought to be formed through the induction of a highly conserved arterial genetic programme in a subset of vessels that will later experience an increase in oxygenated blood flow. The initial steps of arterial specification require both VEGF and Notch signalling. Here, we combined inducible genetic mosaics and transcriptomics to modulate and define the function of these signalling pathways in cell proliferation, arteriovenous (AV) differentiation and mobilization. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TXT
Series
Accession:
GSE158731
ID:
200158731
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