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Links from GEO DataSets

Items: 20

1.

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(Submitter supplied) The study aimed to analyse the transcriptome of mouse cancer cells while in primary tumor, in circulation and after homing to metastatic site. The model used here is the 4T1 cancer cell orthotopic model.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
3 Samples
Download data: TXT
Series
Accession:
GSE37344
ID:
200037344
2.

Expression data from a lung metastatic cell line or metastatic explants in mouse and human

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL23038 GPL23159
40 Samples
Download data: CEL
Series
Accession:
GSE99557
ID:
200099557
3.

Expression data from lung metastatic explants

(Submitter supplied) The role of PGC1alpha in breast cancer lung metastasis is largely unknown. We used expression data from lung metastatic explants overexpressing PGC1alpha or control, treated with phenformin to understand global gene expression changes which occur in a PGC1alpha context and under phenformin treatment. We used expression data to understand the pathways and genes that may lead to lung metastasis in a PGC1alpha overexpression setting.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
12 Samples
Download data: CEL, TXT
Series
Accession:
GSE99556
ID:
200099556
4.

Expression data from lung metastasis

(Submitter supplied) The role of PGC1alpha in breast cancer lung metastasis is largely unknown. We used expression data from lung metastasis of mice injected with PGC1alpha overexpression or control cells to understand global changes that occur upon overexpression of PGC1alpha that lead to lung metastasis. We used expression data to understand the pathways and genes that may lead to lung metastasis in a PGC1alpha overexpression setting.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
22 Samples
Download data: CEL, TXT
Series
Accession:
GSE99555
ID:
200099555
5.

Expression data from a human lung metastatic cell line treated with siPGC1alpha or siControl

(Submitter supplied) To understand global expression changes in a knockdown of PGC1alpha (siPGC1alpha) vs control (siControl) in a lung metastatic cell line (4175) Metabolic adaptations play a key role in fuelling tumour growth. However, less is known regarding the metabolic changes that promote cancer progression to metastatic disease. Herein, we reveal that PGC-1a expression and activity are differentially regulated depending on breast cancer metastatic sites. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23159
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE99554
ID:
200099554
6.

ChIPSeq data from melanoma cancer cell line CHL-1 after Bromodomain and extra terminal (Bet) domain inhibitor treatment

(Submitter supplied) Bromodomain and extra terminal domain (BET) inhibition reduces occupancy of BET-family proteins at promoter and enhancer sites finally leading to genome wide changes in gene transcription. We used ChIPSeq profiling to investigate genome wide changes in promoter and enhancer occupancy induced by BET inhibitors BAY 1238097 and OTX-015, respectively.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16791
18 Samples
Download data: BW
Series
Accession:
GSE95585
ID:
200095585
7.

Progressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation

(Submitter supplied) Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4904
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE52550
ID:
200052550
8.
Full record GDS4904

Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle

Analysis of muscle from aged animals with muscle-specific Pgc-1α depletion. PGC-1alpha is a transcriptional coactivator of the mitochondrial gene program. Results provide insight into the role of Pgc-1α in the glucose intolerance and chronic systemic inflammation associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE52550
12 Samples
Download data: CEL
9.

mTOR pathway controls mitochondrial gene expression and respiration through the YY1/PGC-1alpha transcriptional complex

(Submitter supplied) Mitochondrial oxidative function is tightly controlled to maintain energy homeostasis in response to nutrient and hormonal signals. An important cellular component in the energy sensing response is the target of rapamycin (TOR) kinase pathway; however whether and how mTOR controls mitochondrial oxidative activity is unknown. Here, we show that mTOR kinase activity stimulates mitochondrial gene expression and oxidative function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE5332
ID:
200005332
10.

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

(Submitter supplied) Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1α. We could then efficiently knockdown PGC-1β expression by shRNA expression. Loss of PGC-1α did not alter brown fat differentiation but severely reduced the induction of thermogenic genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2123
Platform:
GPL1261
6 Samples
Download data
Series
Accession:
GSE5042
ID:
200005042
11.

Expression of the brown fat thermogenic gene program requires PGC-1alpha

(Submitter supplied) To investigate the specific role of PGC-1 coactivators in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1alpha. We could then efficiently knockdown PGC-1beta expression by shRNA expression. Loss of PGC-1alpha did not alter brown fat differentiation but severly reduced the induction of thermogenic genes. In order to assess the specific requirement for PGC-1α in the global transcriptional response to cAMP, we used Affymetrix arrays to compare the sets of genes induced in response to a 4 hr dbcAMP treatment in differentiated wt and KO cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2149
Platform:
GPL1261
8 Samples
Download data
Series
Accession:
GSE5041
ID:
200005041
12.
Full record GDS2149

PGC-1alpha null brown adipocyte response to cAMP

Analysis of PGC-1alpha null brown adipocytes treated with cAMP for 4 hours. PGC-1alpha is required for the thermogenic function of brown fat cells, and cAMP plays a role in thermogenesis. Results provide insight into the role of PGC-1alpha in the global transcriptional response to cAMP.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5041
8 Samples
Download data
DataSet
Accession:
GDS2149
ID:
2149
13.
Full record GDS2123

Brown fat cell response to PGC-1alpha and PGC-1beta deficiency

Analysis of brown fat cells lacking PGC-1alpha or both PGC-1alpha and PGC-1beta. PGC-1alpha is required for the thermogenic function of brown fat cells, and PGC-1beta is the closest homolog of PGC-1alpha. Results provide insight into the specific roles of PGC-1alpha and PGC-1beta in brown fat cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5042
6 Samples
Download data
DataSet
Accession:
GDS2123
ID:
2123
14.

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α

(Submitter supplied) Mutant forms of p53 protein often possess pro-tumorigenic function, conferring increased survival and migration to tumor cells via its “gain of function” activity. Whether and how a common polymorphism in TP53 at amino acid 72 (Pro72Arg, hereafter P72 and R72) impacts this gain of function has not been determined. We show that mutant p53 enhances migration and metastasis of tumors through the ability to bind and regulate PGC-1α, and that this regulation is markedly impacted by the codon 72 polymorphism. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
11 Samples
Download data: TXT
Series
Accession:
GSE109373
ID:
200109373
15.

Analysis of PGC-1alpha overexpression effects on the whole transcriptome in cultured skeletal muscle cells

(Submitter supplied) The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) is a chief activator of the mitochondrial and metatolic program in skeletal muscle (skm) and prevents atrophy. Here we tested whether PGC-1α overexpression could restructure the transcriptome and metabolism of cultured human skeletal myotubes, which display an athropic phenotype. An oligonucleotide microarray analysis was used to reveal PGC-1α effects on the whole transcriptome, and the possible impact on fuel metabolism reprogramming was examined. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
6 Samples
Download data: TXT
Series
Accession:
GSE28206
ID:
200028206
16.

PGC-1β Promotes Enterocyte Lifespan and Tumorigenesis in the Intestine

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
30 Samples
Download data
Series
Accession:
GSE61643
ID:
200061643
17.

Genome-wide analysis expression of ileum tumor samples from FVBN/APCmin and iPGC-1β/APCmin

(Submitter supplied) Analysis of metabolic pathway gene expression. The hypothesis tested in the present study is to assess mRNA level changes in metabolic genes in intestinal tumors from APCmin mice overexpressing PGC-1β specifically in the intestine.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
12 Samples
Download data: TXT
Series
Accession:
GSE61642
ID:
200061642
18.

Genome-wide analysis expression of ileum samples from wild-type and iPGC-1β

(Submitter supplied) Analysis of metabolic pathway gene expression. The hypothesis tested in the present study is to assess mRNA level changes in metabolic genes in enterocytes from transgenic mice overexpressing PGC-1β specifically in the intestine.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
10 Samples
Download data: TXT
Series
Accession:
GSE61641
ID:
200061641
19.

Genome-wide analysis expression of ileum samples from PGC-1β fl/? and iKOPGC-1β

(Submitter supplied) Analysis of metabolic pathway gene expression. The hypothesis tested in the present study is to assess mRNA level changes in metabolic genes in enterocytes from intestine specific PGC-1β konckout mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE61640
ID:
200061640
20.

Skeletal muscle PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction.

(Submitter supplied) Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation and reactive oxygen species scavenging in skeletal muscle and other tissues, and these processes are thought to be critical to the benefits of CR. PGC-1a is a transcriptional coactivator that regulates mitochondrial function and is induced by CR. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
26 Samples
Download data: CEL
Series
Accession:
GSE34773
ID:
200034773
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