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Links from GEO DataSets

Items: 20

1.

Characterization of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows a strong conservation of involved transcription factors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL15592 GPL11084
30 Samples
Download data: CEL
Series
Accession:
GSE38124
ID:
200038124
2.

Expression Profiles of PMH treated with 7µM of the genotoxic compound cisplatin

(Submitter supplied) The transcriptomic changes induced in primary mouse hepatocytes (C57BL/6 ) by 7µM of cisplatin after treatment for 24 and 48h
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL15592
12 Samples
Download data: CEL
Series
Accession:
GSE38123
ID:
200038123
3.

Expression Profiles of HepG2 cells treated with 7µM of the genotoxic compound cisplatin

(Submitter supplied) The transcriptomic changes induced in the human liver cell line HepG2 by 7µM of cisplatin after treatment for 12, 24 and 48h
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL11084
18 Samples
Download data: CEL
Series
Accession:
GSE38122
ID:
200038122
4.

Analyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

(Submitter supplied) For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics are highly desired. In the present study, the transcriptomics responses following exposure to genotoxic (GTX) and non-genotoxic (NGTX) hepatocarcinogens and non-carcinogens (NC) in five liver-based in vitro models, namely conventional and epigenetically-stabilized cultures of primary rat hepatocytes, the human hepatoma-derived HepaRG and HepG2 cell lines and the human embryonic stem cell-derived hepatocyte-like cells hES-Heps are examined and compared.
Organism:
Homo sapiens; Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL13916 GPL15933
548 Samples
Download data: CEL
Series
Accession:
GSE40117
ID:
200040117
5.

Evaluating mRNA and microRNA profiles reveals discriminative and compound-specific responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus; Rattus norvegicus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL18609 GPL18615
120 Samples
Download data: CEL, GPR, TXT
Series
Accession:
GSE57132
ID:
200057132
6.

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Affymetrix]

(Submitter supplied) The study investigated differential gene expression in primary mouse hepatocyte mRNA following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological replicates per compound/solvent.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18615
60 Samples
Download data: CEL
Series
Accession:
GSE57129
ID:
200057129
7.

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Exiqon]

(Submitter supplied) The study investigated differential miRNA changes in primary mouse hepatocyte following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological replicates per compound/solvent.
Organism:
Homo sapiens; Mus musculus; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL18609
60 Samples
Download data: GPR, TXT
Series
Accession:
GSE57082
ID:
200057082
8.

Thalidomide induced early gene expression perturbations indicative of human embryopathy in mouse embryonic stem cells

(Submitter supplied) To unravel the mechanisms of thalidomide developmental toxicity, we used microarrays to study transcriptomic changes induced by thalidomide during mouse embryonic stem cell (mESC) differentiation. C57BL/6 mESCs were allowed to differentiate spontaneously and global gene expression changes were studied using microarrays at at different time points after exposure to 0.25 mM thalidomide (THD).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
18 Samples
Download data: CEL
Series
Accession:
GSE61306
ID:
200061306
9.

Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL9052 GPL13695
16 Samples
Download data: CEL, TXT
Series
Accession:
GSE36244
ID:
200036244
10.

Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (Affymetrix)

(Submitter supplied) Whole-genome transcriptome measurements are pivotal for characterizing carcinogenic mechanisms of chemicals and predicting toxic classes, such as genotoxicity, from in vitro and in vivo assays. DNA microarrays have evolved as the gold standard for this purpose. In recent years deep sequencing technologies have been developed that hold the promise of measuring the transcriptome with RNA-seq in a more accurate and unbiased manner than microarrays. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13695
8 Samples
Download data: CEL, TXT
Series
Accession:
GSE36243
ID:
200036243
11.

Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (RNA-Seq)

(Submitter supplied) Whole-genome transcriptome measurements are pivotal for characterizing carcinogenic mechanisms of chemicals and predicting toxic classes, such as genotoxicity, from in vitro and in vivo assays. DNA microarrays have evolved as the gold standard for this purpose. In recent years deep sequencing technologies have been developed that hold the promise of measuring the transcriptome with RNA-seq in a more accurate and unbiased manner than microarrays. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9052
8 Samples
Download data: TXT
Series
Accession:
GSE36242
ID:
200036242
12.

Signature of human hepatocytes treated with Aroclor1254

(Submitter supplied) In order to determine molecular rules for transcriptional regulation of targeted genes to explain in part the pleiotropic effect observed in animals and humans upon exposure to Aroclor 1254 we treated human hepatocytes with Aroclor1254 and analysed RNA expression using a Nimblegene human custom array. Keywords: Human hepatocytes, Aroclor1254 treatment, 20µM, 72h
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL3872
2 Samples
Download data
Series
Accession:
GSE5213
ID:
200005213
13.

Gene expression profiling to recognize specific features of (non-) genotoxic carcinogens

(Submitter supplied) The current test strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Non-genotoxic carcinogens (NGTXC) are negative for genotoxicity and go undetected. Therefore, alternative tests to detect these chemicals are urgently needed. NGTXC act through different modes of action, which complicates the development of such assays. We have demon­strated recently in primary mouse hepatocytes that some, but certainly not all, NGTXC can be categorized according to their mode of action based on feature detection at a gene expression level (Schaap et al. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17198
88 Samples
Download data: CEL
Series
Accession:
GSE47345
ID:
200047345
14.

Gene expression profiling to recognize specific features of non-genotoxic carcinogens

(Submitter supplied) The current test strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Non-genotoxic carcinogens (NGTXC) are negative for genotoxicity and go undetected. Therefore, alternative tests to detect these chemicals are urgently needed. NGTXC act through different modes of action, which complicates the development of such assays. We have demonstrated recently in primary mouse hepatocytes that some, but certainly not all, NGTXC can be categorized according to their mode of action based on feature detection at a gene expression level (Schaap et al. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL15125
111 Samples
Download data: CEL, TXT
Series
Accession:
GSE44088
ID:
200044088
15.

Hepatotoxicity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
300 Samples
Download data: CEL, CHP
Series
Accession:
GSE40348
ID:
200040348
16.

Effect of Methapyrilene on Rat Primary Hepatocytes.

(Submitter supplied) This study provides an evaluation of changes in gene expression associated with methapyrilene treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (3 uM and 100 uM) of methaphyriline and 1% DMSO vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
30 Samples
Download data: CEL, CHP
Series
Accession:
GSE40347
ID:
200040347
17.

Effect of WY-14643 on Rat Primary Hepatocytes.

(Submitter supplied) This study provides an evaluation of changes in gene expression associated with WY-14643 treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses 8 uM and 200 uM) of WY-14643 and 1% DMSO vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
30 Samples
Download data: CEL, CHP
Series
Accession:
GSE40346
ID:
200040346
18.

Effect of Clofibrate on Rat Primary Hepatocytes.

(Submitter supplied) This study provides an evaluation of changes in gene expression associated with clofibrate treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (60 uM and 1 mM) of clobibrate and 1% DMSO vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
30 Samples
Download data: CEL, CHP
Series
Accession:
GSE40344
ID:
200040344
19.

Effect of Diisononyl Phthalate on Rat Primary Hepatocytes.

(Submitter supplied) This study provides an evaluation of changes in gene expression associated with diisononyl phthalate treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (25 mM and 100 mM) of diisononyl phthalate and 1% DMSO vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
30 Samples
Download data: CEL, CHP
Series
Accession:
GSE40342
ID:
200040342
20.

Effect of Chlorpromazine HCl on Rat Primary Hepatocytes.

(Submitter supplied) This study provides an evaluation of changes in gene expression associated with chlorpromazine HCl treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (0.8 uM and 20 uM) of chlorpromazine HCl and 1% DMSO vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
30 Samples
Download data: CEL, CHP
Series
Accession:
GSE40341
ID:
200040341
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