Similar studies for GEO DataSets (Select 200038747) - GEO DataSets

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Items: 2

Select item 2000387471.

Regulatory role of multinucleated giant cells derived from placental CD14+ macrophages: Pathophysiological implications

(Submitter supplied) The role of placental macrophages is largely ignored in the success of pregnancy. We found that CD14+ macrophages purified from at-term placentas spontaneously matured into multinucleated giant cells (MGCs). MGCs lost the expression of CD14 and co-inhibitory molecules, such as Programmed cell Death-Ligands 1 and 2. Although MGCs kept phagocytosis and property to produce ROS, their inflammatory potential measured by TNF/IL-10 imbalance and activation of p38 MAPK and NF-κB was blunted without being associated with M2 phenotype. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5314
Platform:: GPL6480
12 Samples

Download data: TXT

Series

Accession:: GSE38747

ID:: 200038747

Select item 53142.

Placental CD14+ macrophage-derived multinucleated giant cells

Analysis of placental multinucleated giant cells (MGCs) obtained from at-term placental CD14+ macrophages cultured in DMEM-F12 containing 10% FCS and antibiotics for 9 days. Results provide insight into molecular mechanisms underlying the maturation of macrophages into MGCs.