Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.

Transcript atlases reveal that artery tertiary lymphoid organs but not secondary lymphoid organs control key steps of atherosclerosis T cell immunity in aged apoe-/- mice.

(Submitter supplied) Tertiary lymphoid organs (TLOs) emerge in response to nonresolving inflammation but their roles in adaptive immunity remain unknown. Here, we explored artery TLOs (ATLOs) to delineate atherosclerosis T cell responses in apoe-/- mice during aging. Though the T cell repertoire showed systemic age-associated contractions in size and modifications in subtype composition and activation, wt and apoe-/- mice were equally affected. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL8321 GPL1261
65 Samples
Download data: CEL, EXP
Series
Accession:
GSE40156
ID:
200040156
2.

Laser Capture Microdissection of Hyperlipidemic Mouse Aorta Atherosclerosis

(Submitter supplied) Atherosclerosis is a transmural chronic inflammatory condition of small and large arteries that is associated with adaptive immune responses at all disease stages. However, impacts of adaptive immune reactions on clinically apparent atherosclerosis such as intima lesion (plaque) rupture, thrombosis, myocardial infarction, and aneurysm largely remain to be identified. It is increasingly recognized that leukocyte infiltrates in plaque, media, and adventitia are distinct but their specific roles have not been defined. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
19 Samples
Download data: CEL
Series
Accession:
GSE21419
ID:
200021419
3.

Age-dependent aorta transcriptomes in wild-type and apoE-deficient C57BL/6J mice

(Submitter supplied) We previously observed that formation of aorta and innominate artery atherosclerotic lesions in the intima of hyperlipidemic apoE-deficient mice but not wild-type mice was accompanied by a marked age-dependent adventitial T cell infiltration. As the mice aged, adventitial T cells formed T/T cell-, T/B cell-, and T/B/dendritic cell aggregates adjacent to atherosclerotic lesions. Some of the adventitial infiltrates formed large clusters of various immune cells including T cells, B cells (centrocytes, follicular mantle cells), dendritic cells, follicular dendritic cells, and plasma cells with preferential formation in the suprarenal portion of the abdominal aorta. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL8321 GPL1261
35 Samples
Download data: CEL, EXP
Series
Accession:
GSE10000
ID:
200010000
4.

Comparison of gene expression in aorta and CD115+ isolated circulating cells from apoE-/- versus apoE-/-LTbR-/- mice

(Submitter supplied) Affymetrix Microarrays were used to analyse gene expression in aortas and circulating CD115+ cells of ApoE- and ApoE/Lymphotoxin beta receptor (LTbR)-double-deficent mice fed a Western diet from 8 to 12 weeks of age in order to identify regulated genes and pathways leading to reduced atherosclerosis in ApoE-/-/LTbR-/- mice compared to ApoE-/- littermate controls.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
14 Samples
Download data: CEL
Series
Accession:
GSE63259
ID:
200063259
5.

Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizers upon combined TNFR1/LTBR NF-kB signaling

(Submitter supplied) Cultured mouse aorta endothelial cells (from 8-12 weeks old C57BL/6J mice, passage 2-3) were exposed to phosphate buffered saline (control) or a combination of TNFalpha plus agonistic alpha-LTßR antibody for 24 hours as described in Lötzer et al. 2009. Arterioscler. Thromb. Vasc. Biol., in press. Total RNA was extracted and microarrays were prepared.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3810
Platform:
GPL1261
5 Samples
Download data: CEL
Series
Accession:
GSE19139
ID:
200019139
6.

Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizers upon combined TNFR1/LTBR NF-kB signaling

(Submitter supplied) Mouse aorta smooth muscle cells (SMCs) express TNF receptor superfamily member 1A (TNFR1) and lymphotoxin ß receptor (LTßR). Circumstantial evidence has linked the SMC LTßR to tertiary lymphoid organogenesis in diseased aortae of hyperlipidemic mice. Here, we explored potential roles of TNFR1 and LTßR activation in cultured SMCs. TNFR1 signaling by TNF activated the classical RelA NF-κB pathway, whereas LTßR signaling by agonistic anti LTßR antibody activated both the classical RelA and alternative RelB NF-κB pathways. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3809
Platform:
GPL1261
21 Samples
Download data: CEL
Series
Accession:
GSE15062
ID:
200015062
7.
Full record GDS3810

TNF receptor and lymphotoxin beta -receptor activation effect on aortic endothelial cells in vitro

Analysis of cultured aortic endothelial cells stimulated with a combination of tumor necrosis factor (TNF) and α-LTßR antibody for 24 hours. Unlike similarly-treated aortic smooth muscle cells (SMCs), the endothelial cells did not differentiate into a lymphoid tissue organizer (LTO) phenotype.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL1261
Series:
GSE19139
5 Samples
Download data: CEL
8.
Full record GDS3809

TNF receptor and lymphotoxin beta -receptor activation effect on aortic smooth muscle cells in vitro: time course

Analysis of cultured aortic smooth muscle cells (SMCs) stimulated with a combination of tumor necrosis factor (TNF) and α-LTβR monoclonal antibody for up to 24 hours. SMCs stimulated by TNF/α-LTβR mAb, but not with either agent alone, differentiate into lymphoid tissue organizer (LTO)-like cells
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 agent, 3 time sets
Platform:
GPL1261
Series:
GSE15062
21 Samples
Download data: CEL
9.

eQTL study of bone marrow derived macrophages and endothelial cells from DBA2xAKR F2 mice

(Submitter supplied) An eQTL analysis between DBA/2J and AKR/J mice strains on the ApoE null background was done in bone marrow derived macrophages and endothelial cells to identify modifier genes that affect atherosclerosis susceptibility.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
218 Samples
Download data: TXT
Series
Accession:
GSE35676
ID:
200035676
10.

Ath29 congenic mice - gene expression in aorta

(Submitter supplied) A congenic mouse line was constructed by introgressing a C3H chromosome 9 region harboring Ath29 into the C57BL/6 apoE-deficient background. RNA was extracted from aorta using a QIAGEN kit . Total RNA was pooled in an equal amount from 3 mice for each group. Standard Affymetrix procedures were performed using 8ug of total RNA. Microarrays were used to detect gene expression in the aorta of Ath29 congenic mice and C57BL/6 apoE-deficient mouse strains fed a chow or western diet.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE29149
ID:
200029149
11.

C57BL/6 C3H/HeJ apoE-/- mice - gene expression in aorta

(Submitter supplied) Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit a marked difference in their susceptibility to atherosclerosis and the arterial wall has proven to be a source of the difference in atherosclerosis susceptibility. Genome-wide gene expression analysis was conducted in aortic walls of the two strains. Total RNA was extracted from aortas of 6-week-old female B6 and C3H apoE-deficient (apoE-/-) mice fed a chow or Western diet. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
4 Samples
Download data: CEL
Series
Accession:
GSE14854
ID:
200014854
12.

Common pathways involved in adipose tissue inflammation and atherosclerosis

(Submitter supplied) Adipose tissue inflammation and atherosclerosis are the main mechanisms behind type 2 diabetes and cardiovascular disease respectively, the major risks associated with the metabolic syndrome. Studies considering more than single factors behind the complexity of the metabolic syndrome are valuable to achieve a better and wider understanding of the metabolic syndrome. In this study common dysregulated pathways between adipose tissue inflammation and atherosclerosis were identified using two different bioinformatic tools to perform pathway analysis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
18 Samples
Download data: CEL
Series
Accession:
GSE76812
ID:
200076812
13.

Aortas of mice on high fat diet

(Submitter supplied) Expression profiles in aortas isolated from mouse strains C3H.2/HeJ and C57.2Bl/6. Mice were were either on a high fat diet or normal diet for 0, 4, 10, 24, or 40 weeks. Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS735
Platform:
GPL891
54 Samples
Download data
Series
Accession:
GSE1560
ID:
200001560
14.
Full record GDS735

High fat diet effect on aorta: time course

Comparison of gene expression in aortas of C57BL/6 and C3H/HeJ fed identical high fat diets at 0, 4, 8, 24, and 40 weeks. C57BL/6 has a greater tendency than C3H/HeJ to develop atherosclerotic aortic lesions when both fed identical high fat diets.
Organism:
Mus musculus
Type:
Expression profiling by array, log ratio, 2 growth protocol, 2 strain, 5 time sets
Platform:
GPL891
Series:
GSE1560
54 Samples
Download data
DataSet
Accession:
GDS735
ID:
735
15.

Adventitial tertiary lymphoid organs in AAA are a potential source of miRNAs as biomarkers

(Submitter supplied) This study aims to identify and characterize miRNA expression inATLOs isolated by laser microdissection from human AAA biopsy samples. The aim of this study was to profile (with microarray technology) miRNAs in ATLOs (Adventitial tertiary lymphoid organs), isolated by laser capture microdissection (LCM). Smooth muscle cells (SMCs) isolated from control non-aneurysmal aortas were the control group according to which data were normalized. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platforms:
GPL14767 GPL14943
4 Samples
Download data: TXT
Series
Accession:
GSE63541
ID:
200063541
16.

Genome-wide DNA methylation aberrations in human atherosclerosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing; Methylation profiling by array
Platforms:
GPL11154 GPL13534
51 Samples
Download data: TXT
Series
Accession:
GSE46401
ID:
200046401
17.

Genome-wide DNA methylation aberrations in human atherosclerosis (450K)

(Submitter supplied) Epigenetics may help understanding the molecular mechanisms of atherosclerosis as genetic predisposition explains only part of cardiovascular disease risk. In particular, DNA methylation, a reversible and highly regulative DNA modification could contribute to disease onset and progression as it functions as effector for environmental impacts, including dietary and life-style, similarly to risk factors for cardiovascular diseases. more...
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL13534
49 Samples
Download data: TXT
Series
Accession:
GSE46394
ID:
200046394
18.

Genome-wide DNA methylation aberrations in human atherosclerosis (sequencing)

(Submitter supplied) Epigenetics may help understanding the molecular mechanisms of atherosclerosis as genetic predisposition explains only part of cardiovascular disease risk. In particular, DNA methylation, a reversible and highly regulative DNA modification could contribute to disease onset and progression as it functions as effector for environmental impacts, including dietary and life-style, similarly to risk factors for cardiovascular diseases. more...
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL11154
2 Samples
Download data: TXT
Series
Accession:
GSE46327
ID:
200046327
19.

Laser-capture microscopy coupled with Smart-seq2 (LCM-seq) for robust and efficient transcriptomic profiling of mouse and human tissues

(Submitter supplied) Generally, when LCM is used in diverse transcriptomic analyses, several hundred, if not thousands, of cells are needed to obtain high quality of RNA-seq data. As some cellular populations are very small and tissue often in scarcity, we aimed to carefully document the lowest number of cells needed to retrieve sequencable libraries. We started with capturing 120 cells and subsequently scaled down to 50 cells, 30 cells, 10 cells, 5 cells, 2 cells and finally 1 cell. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL11154
153 Samples
Download data: TXT
Series
Accession:
GSE76514
ID:
200076514
20.

Expression Data from human Lung tissue of Patients with Non Small Cell Lung Cancer (NSCLC)

(Submitter supplied) Lung cancers are a heterogeneous group of diseases with respect to biology and clinical behavior. Currently, diagnosis and classification are based on histological morphology and immunohistological methods for discrimination between two main histologic groups: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) which account for 20% and 80% of lung carcinomas, respectively. NSCLCs, which are divided into the three major subtypes adenocarcinoma, squamous cell carcinoma and dedifferentiated large cell carcinoma, show different characteristics such as the expression of certain keratins or production of mucin and lack of neuroedocrine differentiation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
131 Samples
Download data: CEL, CHP, TXT, XLS
Series
Accession:
GSE31552
ID:
200031552
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=3|blobid=MCID_61a5cd9b5c3c641ea22affd3|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center