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Links from GEO DataSets

Items: 12

1.

Rapamycin extends life span, but has limited effects on aging in mice

(Submitter supplied) Rapamycin extends life span in mice, but it remains unclear if this compound also delays mammalian aging. Here, we present results from a comprehensive large-scale assessment of a wide rage of structural and functional aging phenotypes in mice. Rapamycin extended life span but showed few effects on a large number of systemic aging phenotypes, suggesting that rapamycin's effects on aging are largely limited to the regulation of age-related mortality and carcinogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
30 Samples
Download data: TXT
Series
Accession:
GSE41018
ID:
200041018
2.

Late life rapamycin treatment reverses age-related heart dysfunction

(Submitter supplied) We report the mRNA profile of aged mice (24 months old) fed either a control diet or a diet containing Rapamycin (14 ppm) for 3 months. After drug treatement, the hearts of the mice were removed and total mRNA was removed from the tissue. Analysis revealed that there were 700 significantly differentially expressed genes between the control fed group and the Rapamycin diet group by our analysis.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
20 Samples
Download data: TXT
Series
Accession:
GSE48043
ID:
200048043
3.

The mTOR pathway is necessary for survival of mice with short telomeres.

(Submitter supplied) Gene expression profiles of Terc+/+ and generation 2 (G2) Terc-/- male mice fed rapamycin or control diet during 2 months. Rapamycin diet contains encapsulated rapamycin at 42 ppm (mg of drug per kg of food); control diet contains coating material (Eudragit S100). Rapamycin was microencapsulated by Rapamycin Holdings Inc. (San Antonio, Texas) and was then incorporated into 5LG6 mouse chow (TestDiet, London, UK).
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: PDF, TXT
Series
Accession:
GSE127475
ID:
200127475
4.

The effect of Rapamycin on the transcriptome of old mouse liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
111 Samples
Download data
Series
Accession:
GSE48334
ID:
200048334
5.

The effect of chronic Rapamycin on the transcriptome of old mouse liver

(Submitter supplied) Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin chronically (21 months) from 4 months of age.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
69 Samples
Download data: TXT
Series
Accession:
GSE48333
ID:
200048333
6.

The effect of short term Rapamycin on the transcriptome of old mouse liver

(Submitter supplied) Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin short term (6 months) Rapamycin from 19 months of age.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
42 Samples
Download data: TXT
Series
Accession:
GSE48331
ID:
200048331
7.

Short-term rapamycin treatment in mice have few effects on the transcriptome of white adipose tissue compared to dietary restriction

(Submitter supplied) Analysis of the transcriptome in the epididymal fat of young mice (8 months of age) from treatment of dietary restriction, or rapamycin
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
24 Samples
Download data: TXT
Series
Accession:
GSE52825
ID:
200052825
8.

Identification and application of gene expression signatures associated with lifespan extension

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL24247
102 Samples
Download data
Series
Accession:
GSE131901
ID:
200131901
9.

RNA sequencing of mouse hepatic response to compounds with predicted lifespan-extending effect

(Submitter supplied) This dataset consists of hepatic gene expression profiles of mice subjected to 4 compounds predicted by Connectivity Map (CMap) using gene signatures identified for known lifespan-extending interventions: ascorbyl-palmitate, KU-0063794, AZD8055 and rilmenidine. Corresponding age-, sex- and strain-matched littermate controls are also presented. Using this data, we confirmed the association between longevity signatures and gene expression response to the predicted compounds in vivo, using the same mouse model as for the identification of gene signatures associated with lifespan extension. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
24 Samples
Download data: TXT
Series
Accession:
GSE131868
ID:
200131868
10.

RNA sequencing of mouse hepatic response to lifespan-extending interventions

(Submitter supplied) This dataset consists of hepatic gene expression profiles of mice subjected to 8 different lifespan-extending interventions, together with the corresponding age-, sex- and strain-matched littermate controls: caloric restriction (CR), methionine restriction (MR), growth hormone receptor knockout (GHRKO), Snell dwarf mice (Pit1 -/-), rapamycin, acarbose, 17-alpha-estradiol (17aE2) and Protandim. Both sexes and different age groups are presented within dataset. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
78 Samples
Download data: TXT
Series
Accession:
GSE131754
ID:
200131754
11.

Every-other-day feeding extends lifespan but fails to prevent many symptoms of aging in mice

(Submitter supplied) Dietary restriction is a well-known model to induce longevity across a variety of model organisms ranging from worms, flies to mammals. However, whether lifespan extension is associated with retardation of aging phenotypes still remains unclear. Here, we address whether every-other-day feeding affects age-related gene expression in the brain.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
15 Samples
Download data: TXT
Series
Accession:
GSE96644
ID:
200096644
12.

Short-term low-dose mTORC1 inhibition in aged rats counter-regulates age-related gene changes and blocks age-related kidney pathology

(Submitter supplied) Rapalogs, inhibitors of mTORC1 (mammalian target of rapamycin complex 1), increase life span and delay age-related phenotypes in many species. However, the molecular mechanisms have not been fully elucidated. We determined gene expression changes comparing 6- and 24-month-old rats in the kidney, liver, and skeletal muscle, and asked which of these changes were counter-regulated by a clinically-translatable (short-term and low-concentration) treatment, with a rapalog (RAD001). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18694
84 Samples
Download data: BW, TXT
Series
Accession:
GSE108978
ID:
200108978
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