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Links from GEO DataSets

Items: 10

1.

Sca-1 is an early-response target of histone deacetylase inhibitors and marks hematopoietic cells with enhanced function

(Submitter supplied) Expression profiles of LSK cells stimulated for 24h in the presence or in the absence of of valproic acid (VPA) The molecular process that underlies the biological effects of valproic acid (VPA), a widely used histone deacetylase inhibitor, on HSPCs was investigated by studying the early-response genes of VPA. Genome-wide gene expression studies revealed overrepresentation of genes involved in glutathione metabolism, receptor and signal transducer activity and changes in the HSPCs surface profile following short, 24h VPA treatment. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
6 Samples
Download data: TXT
Series
Accession:
GSE41020
ID:
200041020
2.

Expression data from untreated and valproic acid (VPA) treated CD34+ Hematopoietic Stem Cells (HSCs)

(Submitter supplied) Histone deacetylase (HDAC) inhibitors are widely utilized in hematopoietic malignance therapy; nevertheless, little is currently known concerning their effects on normal myelopoiesis. In order to investigate a putative interference of HDAC inhibitors in myeloid commitment of hematopoietic stem/progenitor cells (HSPCs) we treated CD34+ cells with valproic acid (VPA). Moreover, we investigate changes in gene expression induced by VPA treatment on HSPCs, by means of microarray analysis in VPA treated and untreated (CTR) CD34+ cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
2 Samples
Download data: CEL, CHP
Series
Accession:
GSE31283
ID:
200031283
3.

mRNA profiles of four developmentally related hematopoietic cell types (LSK, L-S-K+, Gr1+ and Ter119+) isolated from the BM of B6 and D2 mice

(Submitter supplied) The combination of valproic acid and lithium delays hematopoietic stem\progenitor differentiation
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
24 Samples
Download data: TXT
Series
Accession:
GSE35292
ID:
200035292
4.

Expression profiles of 7-day cultured HSPCs in the presence or absence of valproic acid and/or lithium

(Submitter supplied) Two small molecules, valproic acid (VPA) and lithium (Li), were tested to inhibit differentiation of hematopoietic stem/progenitor (HSPC) cells in culture. HSPCs exposed to VPA and Li during differentiation-inducing culture preserved an immature cell phenotype, provided radioprotection to lethally irradiated recipients and enhanced in vivo repopulating potential. Furthermore, VPA and Li synergistically preserved expression of stem cell-related genes and repressed genes involved in differentiation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
12 Samples
Download data: TXT
Series
Accession:
GSE35291
ID:
200035291
5.

The combination of valproic acid and lithium prevents hematopoietic stem/progenitor cell differentiation.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6885 GPL6887
36 Samples
Download data
Series
Accession:
GSE34088
ID:
200034088
6.

Effect of valproic acid on hematopoiesis: A functional profiling and cell phenotyping approach

(Submitter supplied) Analysis of the effects of valproic acid (VPA) on chronic myelogenous leukemia K562 cells. This study attempts to elucidate the effects of VPA on cell homeostasis and hematopoietic differentiation pathways in this cell line.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
15 Samples
Download data: GPR
Series
Accession:
GSE19939
ID:
200019939
7.

Epigenetic and molecular signatures of cord blood CD34(+) cells treated with histone deacetylase inhibitors

(Submitter supplied) Gene expression profiling of primary cord blood hematopoietic stem cell (day 0, CD34+ cells), enriched control (untreated), Scriptaid and Valproic acid expanded CD34+ cells after a week in culture. Cord blood CD34+ cells were processed individually and equal number of PC and reisolated CD34+ cells from 3-4 samples were pooled after expansion to avoid sample variations.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
8 Samples
Download data: TXT
Series
Accession:
GSE59803
ID:
200059803
8.

In Vivo Chemical Screen Nominates Valproic Acid as Pharmacologic Modulator of Hematopoietic Stem and Progenitor Cell Activity

(Submitter supplied) The identification of small molecules which either increase the number and/or enhance the activity of CD34+ hematopoietic stem and progenitor cells (HSPCs) during ex-vivo expansion has remained challenging. Applying an unbiased in vivo chemical screen in a transgenic (c-myb:EGFP) zebrafish embryo model, histone deacetylase inhibitors (HDACI) (valproic acid, resminostat and entinostat) were shown to significantly amplify the number of phenotypic hematopoietic precursors. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
8 Samples
Download data: CSV
Series
Accession:
GSE90552
ID:
200090552
9.

Expression data from Sca-1 knockout mice

(Submitter supplied) The role of Sca-1 on mammary tumorigenesis was assessed. Microarrays were used to analyse global gene expression changes in Sca-1 KO mice versus wild-type mice and determine the differential responses to MP and DMBA-induced Mammary carcinogenesis
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5500
Platform:
GPL8321
4 Samples
Download data: CEL
Series
Accession:
GSE31954
ID:
200031954
10.
Full record GDS5500

Stem cell antigen-1 deficient mammary tumor

Analysis of mammary tumors from mutants lacking stem cell antigen-1 (Sca-1), a glycerophosphatidylinositol-anchored protein. Tumorigenesis induced by medroxyprogesterone and 7,12dimethylbenz(a)anthracene treatment. Results provide insight into the role of Sca-1 in mammary gland tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 tissue sets
Platform:
GPL8321
Series:
GSE31954
4 Samples
Download data: CEL
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