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Links from GEO DataSets

Items: 20

1.

Global microRNA profiling of aTC1-6 and bTC1 before and after treatment with cytokines

(Submitter supplied) The study sought to determine the global miRNA profiles of mouse pancreatic cell lines aTC1-6 and bTC1 at steady state and after treatment with a cocktail of pro-inflammatory cytokines (IL1b; IFNg and TNFa) for a time course of 24 and 48 hours. Inflammatory cocktail contains IL1b 50 IU/ml; IFNg 1000 IU/ml; TNFa 1000 IU/ml. MicroRNA expression profiles in both cell lines during the different experimental conditions were determined using TaqMan® Rodent miRNA A+B Cards Set v2.0 (TLDA, Life Technologies). more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL11199
15 Samples
Download data: TXT
Series
Accession:
GSE42970
ID:
200042970
2.

MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage

(Submitter supplied) Inflammatory b-cell failure contributes to type 1 and type 2 diabetes pathogenesis. Proinflammatory cytokines cause b-cell dysfunction and apoptosis, and lysine deacetylase inhibitors (KDACi) prevent b-cell failure in vitro and in vivo, in part by reducing NFkB transcriptional activity. Here we investigated the hypothesis that the protective effect of KDACi involves transcriptional regulation of microRNAs (miRs), potential new targets in diabetes treatment. more...
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL22760
24 Samples
Download data: TXT
Series
Accession:
GSE117451
ID:
200117451
3.

MicroRNA profiling of human pancreatic alpha and beta cells

(Submitter supplied) MicroRNAs (miRNAs) are non-coding RNAs that play a fundamental role in regulation of gene expression affecting differentiation and development. In particular, miRNAs have been described to regulate genes important for pancreatic development and islet function. The aim of this work was to determine the miRNA expression signature in human pancreatic alpha and beta cells. miRNA stability to fixation allowed the study of microRNA in pure populations of human alpha and beta cells sorted by FACS after intracellular staining with glucagon and insulin, respectively. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platforms:
GPL15634 GPL15647
24 Samples
Download data: TXT
Series
Accession:
GSE38360
ID:
200038360
4.

The miRNA-mRNA Interactome of murine iPSC-derived Chondrocytes in Response to Inflammatory Cytokines

(Submitter supplied) The goal of this study was to understand the mechanisms of miRNA regulation of the transcriptome of tissue engineered cartilage in response to IL-1β and TNF-α using an in vitro murine induced pluripotent stem cell (miPSC) model system. miPSCs were chondrogenically differentiated for 21 days and then treated with 1 ng/mL of IL-1β, 20 ng/mL of TNF-α, or control media without cytokines for 0, 4, 12, 24, and 72 hours. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL21493
78 Samples
Download data: TXT
5.

microRNA and mRNA expression in pancreatic islets of 3 and 12 month old male Wistar rats

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL15690 GPL14860
13 Samples
Download data: TXT
Series
Accession:
GSE72466
ID:
200072466
6.

Islet microRNA changes in the rat pancreatic islets during aging

(Submitter supplied) comparison of microRNA expression in the islets of 3- and 12-months old male Wistar rats Aging is a risk factor for a majority of metabolic diseases including type 2 diabetes. During aging pancreatic beta-cell function decreases leading to impaired insulin secretion and proliferation and to an increase in apoptosis. Impairment of pancreatic beta cell functions and survival has been linked to gene expression changes. more...
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL14860
7 Samples
Download data: TXT
Series
Accession:
GSE72465
ID:
200072465
7.

Islet mRNA changes in rat pancreatic islets during aging

(Submitter supplied) comparison of mRNA expression in the islets of 3- and 12-month old male Wistar rats Aging is a risk factor for a majority of metabolic diseases including type 2 diabetes. During aging pancreatic beta-cell function decreases leading to impaired insulin secretion and proliferation and to an increase in apoptosis. Impairment of pancreatic beta cell functions and survival has been linked to gene expression changes. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL15690
6 Samples
Download data: TXT
Series
Accession:
GSE72464
ID:
200072464
8.

Ectopic microRNA-150 transcription mimics GR therapy response in GC sensitive MM1S multiple myeloma cells but fails to overcome GC resistance in MM1R cells

(Submitter supplied) Glucocorticoids (GCs) are commonly used to treat patients suffering from lymphoid malignancies i.e. leukemia and multiple myeloma. Although GCs are known to be strong inducers of apoptosis in lymphoid cells, the molecular determinants of GC therapy resistance are poorly understood. Although GC treatment triggers important changes in gene expression, few studies have addressed the regulatory role of small regulatory microRNAs (miRNAs) in GC therapy response. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
24 Samples
Download data: TXT
Series
Accession:
GSE59805
ID:
200059805
9.

miR-221-3p drives the Shift of M2-Macrophage to a Pro-Inflammatory Function by Modulating JAK3/STAT3 Signaling and is Increased in Rheumatoid Arthritis

(Submitter supplied) We performed a transcriptome analysis of M2 macrophages generated in vitro from monocytes isolated from peripheral blood of healthy donors, and studied the effect of miR-221-3p mimic transfection and stimulation with LPS.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
20 Samples
Download data: TSV
Series
Accession:
GSE133527
ID:
200133527
10.

Differentially expressed genes in human brest cancer specimens

(Submitter supplied) To identify differentially expressed genes in human brest cancer specimens were subjected to Agilent whole genome microarrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL20844
4 Samples
Download data: TXT
Series
Accession:
GSE118539
ID:
200118539
11.

Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines II

(Submitter supplied) To identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, bladder cancer, prostate cancer, renal cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL20844
32 Samples
Download data: TXT, XLSX
Series
Accession:
GSE77790
ID:
200077790
12.

Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines (II)

(Submitter supplied) To identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (bladder cancer, prostate cancer, renal cell carcinoma, oral squamous cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16699
32 Samples
Download data: TXT
Series
Accession:
GSE66498
ID:
200066498
13.

microRNA expression profile in retina and choroid in oxygen-induced retinopathy model

(Submitter supplied) Using Next Generation Sequencing (NGS) we profiled miRNA expression in the retina and choroid during degenerative and NV phases of oxygen-induced retinopathy (OIR).
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL20084
12 Samples
Download data: XLSX
Series
Accession:
GSE129995
ID:
200129995
14.

TTF-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by RT-PCR
Platforms:
GPL17077 GPL11316
99 Samples
Download data: TXT
Series
Accession:
GSE83839
ID:
200083839
15.

TTF-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma [rt-pcr]

(Submitter supplied) Thyroid transcription factor-1 (TTF-1), also known as NKX2-1, plays a role as a lineage-survival oncogene in lung adenocarcinoma with double-edged sword characteristics. Although previous studies steadily accumulated evidence for roles of TTF-1 in the transcriptional regulation of protein-coding genes, very little is known about its regulatory relationship with miRNAs. In this study, we have identified miR-532-5p as a novel transcriptional target of TTF-1 by an integrative approach, which was designed to extract maximal information from expression profiles of both patient tumors in vivo and TTF-1-inducible cell lines in vitro. more...
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL11316
4 Samples
Download data: TXT
Series
Accession:
GSE83838
ID:
200083838
16.

TTF-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma [cell line]

(Submitter supplied) Thyroid transcription factor-1 (TTF-1), also known as NKX2-1, plays a role as a lineage-survival oncogene in lung adenocarcinoma with double-edged sword characteristics. Although previous studies steadily accumulated evidence for roles of TTF-1 in the transcriptional regulation of protein-coding genes, very little is known about its regulatory relationship with miRNAs. In this study, we have identified miR-532-5p as a novel transcriptional target of TTF-1 by an integrative approach, which was designed to extract maximal information from expression profiles of both patient tumors in vivo and TTF-1-inducible cell lines in vitro. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
20 Samples
Download data: TXT
Series
Accession:
GSE83837
ID:
200083837
17.

TTF-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma [pts]

(Submitter supplied) Thyroid transcription factor-1 (TTF-1), also known as NKX2-1, plays a role as a lineage-survival oncogene in lung adenocarcinoma with double-edged sword characteristics. Although previous studies steadily accumulated evidence for roles of TTF-1 in the transcriptional regulation of protein-coding genes, very little is known about its regulatory relationship with miRNAs. In this study, we have identified miR-532-5p as a novel transcriptional target of TTF-1 by an integrative approach, which was designed to extract maximal information from expression profiles of both patient tumors in vivo and TTF-1-inducible cell lines in vitro. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
75 Samples
Download data: TXT
Series
Accession:
GSE83836
ID:
200083836
18.

The microRNA profile in neosquamous oesophageal mucosa following ablation of Barrett's oesophagus

(Submitter supplied) mucosal biopsies were taken from patients at pre and post-argon plasma coagulation (APC) ablation of Barrett's oesophagus, and from healthy controls. Total RNA was extracted using Trizol. miRNA was reversed transcribed using a TaqMan® microRNA Reverse Transcription Kit (Life technologies, #4366596). miRNA profiling was performed with a high throughput TaqMan® OpenArray® Human microRNA panel (Life technologies, #4461104). more...
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL17485
57 Samples
Download data: TXT
Series
Accession:
GSE94854
ID:
200094854
19.

miRNA sequencing profile of isolated Kit+ interstital cells of Cajal (ICC) in Leptin mutant mice

(Submitter supplied) We report the high-throughput miRNA sequencing of isolated colonic and jejunal Kit+ interstitial cells of Cajal (ICC) from Lepob/ob;KitcopGFP mice, which develop type 2 diabetes, and Lepob/+;KitcopGFP mice which are non-diabetic counterparts and control
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: XLS
Series
Accession:
GSE139578
ID:
200139578
20.

miRNA sequencing profile of human plasma samples from healthy, diabetic, and gastroparesis patients

(Submitter supplied) We report the high-throughput miRNA sequencing of plasma isolated from human patients with type 2 diabetes & gastroparesis, idiopathic gastroparesis alone, and healthy control patients.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL16791
8 Samples
Download data: XLSX
Series
Accession:
GSE139577
ID:
200139577
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