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Links from GEO DataSets

Items: 15

1.

Microarray of cardiac biventricle from PGC-1a-/-bf/f/MerCre mice

(Submitter supplied) The following abstract from the submitted manuscript describes the major findings of this work. The metabolic development of high energy-utilizing organs such as the heart involves mitochondrial proliferation at birth followed by a maturation process during the postnatal period. Conditional gene targeting was used in mice to explore the role of the PPARgamma coactivator 1 (PGC-1) coactivators during postnatal development and in adult heart. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4776
Platform:
GPL6246
10 Samples
Download data: CEL
Series
Accession:
GSE43798
ID:
200043798
2.
Full record GDS4776

Peroxisome Proliferator-Activated Receptor γ Coactivator-1 deficiency effect on adult cardiac biventricle

Analysis of heart from adults deficient for peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) α and PGC-1β. Adult PGC-1α/β deficient heart did not exhibit abnormal mitochondrial dynamics or heart failure. Results provide insight into role of PGC-1 coactivators in adult heart.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE43798
10 Samples
Download data: CEL
3.

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

(Submitter supplied) Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1α. We could then efficiently knockdown PGC-1β expression by shRNA expression. Loss of PGC-1α did not alter brown fat differentiation but severely reduced the induction of thermogenic genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2123
Platform:
GPL1261
6 Samples
Download data
Series
Accession:
GSE5042
ID:
200005042
4.

Expression of the brown fat thermogenic gene program requires PGC-1alpha

(Submitter supplied) To investigate the specific role of PGC-1 coactivators in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1alpha. We could then efficiently knockdown PGC-1beta expression by shRNA expression. Loss of PGC-1alpha did not alter brown fat differentiation but severly reduced the induction of thermogenic genes. In order to assess the specific requirement for PGC-1α in the global transcriptional response to cAMP, we used Affymetrix arrays to compare the sets of genes induced in response to a 4 hr dbcAMP treatment in differentiated wt and KO cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2149
Platform:
GPL1261
8 Samples
Download data
Series
Accession:
GSE5041
ID:
200005041
5.
Full record GDS2149

PGC-1alpha null brown adipocyte response to cAMP

Analysis of PGC-1alpha null brown adipocytes treated with cAMP for 4 hours. PGC-1alpha is required for the thermogenic function of brown fat cells, and cAMP plays a role in thermogenesis. Results provide insight into the role of PGC-1alpha in the global transcriptional response to cAMP.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5041
8 Samples
Download data
DataSet
Accession:
GDS2149
ID:
2149
6.
Full record GDS2123

Brown fat cell response to PGC-1alpha and PGC-1beta deficiency

Analysis of brown fat cells lacking PGC-1alpha or both PGC-1alpha and PGC-1beta. PGC-1alpha is required for the thermogenic function of brown fat cells, and PGC-1beta is the closest homolog of PGC-1alpha. Results provide insight into the specific roles of PGC-1alpha and PGC-1beta in brown fat cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5042
6 Samples
Download data
DataSet
Accession:
GDS2123
ID:
2123
7.

Myocardial gene expression in response to pressure overload

(Submitter supplied) Myocardial deletion of klf4 sensitizes mouse to pressure overload. In order to gain a better understanding of molecular mechanisms of such alterations, we profiled gene expression before and after 3-day of pressure overload (induced by transverse aortic constriction -TAC) in the hearts from MHC-cre (Cre) control and MHC-cre-klf4-deficient (KO) mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
15 Samples
Download data: TXT
Series
Accession:
GSE61177
ID:
200061177
8.

Cardiac-specific deletion of ménage-à-trois-1 (MAT1)

(Submitter supplied) The Cdk7/cyclin H/ménage-à-trois 1 (MAT1) heterotrimer has proposed functions in transcription as the kinase component of basal transcription factor TFIIH and is activated in adult hearts by hypertrophic pathways. Using cardiac-specific Cre, we ablated MAT1 in myocardium. Despite reduced Cdk7 activity, MAT1-deficient hearts grew normally. However, fatal heart failure ensued at 6-8 weeks. By microarray profiling, quantitative RT-PCR, and Western blotting at 4 weeks, genes for energy metabolism were found to be suppressed selectively, including targets of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2561
Platform:
GPL81
15 Samples
Download data: CEL
Series
Accession:
GSE6662
ID:
200006662
9.
Full record GDS2561

Cdk7 complex subunit menage-a-trois 1 deficiency effect on hearts

Analysis of 2 and 4 week old hearts ablated for menage-a-trois 1 (MAT1), a subunit of the cdk7/cyclin H/MAT1 heterotrimer. Results provide insight into the role of the cdk7/cyclin H/MAT1 complex in cardiac metabolism.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 protocol sets
Platform:
GPL81
Series:
GSE6662
15 Samples
Download data: CEL
DataSet
Accession:
GDS2561
ID:
2561
10.

RNA-Seq transcriptome profiling of postnatal age 35 days or P35 ventricles of cardiac-specific estrogen-related receptor alpha and gamma (ERRa/g) knock down (KD) mouse generated by AAV-cTnT-Cre injection and its control AAV-Luc injection.

(Submitter supplied) Transcriptional regulatory circuits that drive cardiomyocyte maturation during the developmental process are poorly understood. Estrogen-related receptor alpha and gamma (ERRa/g) have been shown to be involved in all aspects of mitochondrial energy production. However, the function of ERR during the postnatal cardiac developmental process is unclear. To examine the role of (ERRa/g) during postnatal cardiac maturation, we generated inducible cardiac-specific ERRa/g knockdown (KD) mice with adeno-associated virus serotype 9 (AAV9) expressing Cre. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
8 Samples
Download data: XLSX
Series
Accession:
GSE135347
ID:
200135347
11.

Estrogen-related Receptor Signaling Coordinately Controls Cardiac Energy Metabolic and Structural Maturation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL17021 GPL21103
22 Samples
Download data: BW
Series
Accession:
GSE113784
ID:
200113784
12.

RNA-Seq transcriptome profiling of embryonic age 17.5 or E17.5 ventricles of cardiac specific-estrogen-related receptor alpha and gamma (ERRa/g) knock out (KO) mouse generated by Nkx2.5-Cre driver and its control wild type.

(Submitter supplied) Transcriptional regulatory circuits that drive cardiomyocyte maturation during the developmental process are poorly understood. Estrogen-related receptor alpha and gamma (ERRa/g) have been shown to be involved in all aspects of mitochondrial energy production. However, the function of ERR during the cardiac developmental process is not understood well. To examine the role of (ERRa/g), we generated cardiac-specific ERRa/g knockout (KO) mice and found that the KO mice died within 24 hours post-birth. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: XLSX
Series
Accession:
GSE113761
ID:
200113761
13.

Genome-wide estrogen-related receptor gamma (ERRg) occupancy in human iPS cell-derived cardiomyocytes (hiPSC-CMs)

(Submitter supplied) Estrogen-related receptor gamma (ERRg) has been shown to control gene expression involved in a broad range of mitochondrial energy metabolism including oxidative phosphorylation, TCA cycle, and fatty acid oxidation. However, ERRg direct targets were not identified in cardiomyocytes. With ERRg ChIP-seq, we found ERRg peaks on the promoter regions of mitochondrial energy metabolic genes as expected. Besides, ERRg extensively distributed the promoter regions of cardiac contractile, ion channels and Ca2+ handling protein genes. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16791
8 Samples
Download data: BW
Series
Accession:
GSE113760
ID:
200113760
14.

Med1 is Necessary for Cardiac Function

(Submitter supplied) Analysis of ventricular derived mRNA from Med1fl/fl and Med1fl/fl cardiac knockout mice. Results provide insight into the molecual rmechanisms underlying dilated cardiomyopathy.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
8 Samples
Download data: TXT
Series
Accession:
GSE84160
ID:
200084160
15.

Cardiac-specific β-catenin deletion dysregulates energetic metabolism and mitochondrial function in perinatal cardiomyocytes

(Submitter supplied) β-Catenin signaling pathway regulates cardiomyocytes proliferation and differentiation, though its involvement in metabolic regulation of cardiomyocytes remains unknown. We used one-day-old mice with cardiac-specific knockout of β-catenin and neonatal rat ventricular myocytes treated with β-catenin inhibitor to investigate the role of β-catenin metabolism regulation in perinatal cardiomyocytes. Transcriptomics of perinatal β-catenin-ablated hearts revealed a dramatic shift in the expression of genes involved in metabolic processes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
4 Samples
Download data: TXT, XLSX
Series
Accession:
GSE153995
ID:
200153995
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