Similar studies for GEO DataSets (Select 200044958) - GEO DataSets

(Submitter supplied) We report the deregulation of expression in Fi (C57Bl6/J x FVB/n) E14.5 male mouse placenta are that homozygous for a mutant allele of the Smchd1 gene (ie Smchd1MommeD1/MommeD1).

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
10 Samples

Download data: CSV, TXT

Series

Accession:: GSE44668

ID:: 200044668

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000446654.

Genome wide RNA-seq analysis of E9.5 Smchd1 wild type and mutant embryos

(Submitter supplied) We report the deregulation of expression in E9.5 male mouse embryos are that homozygous for a mutant allele of the Smchd1 gene (ie Smchd1MommeD1/MommeD1).

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE44665

ID:: 200044665

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001262575.

Investigating the role of SMCHD1 in regulating clustered protocadherin (Pcdh) and Hox genes

(Submitter supplied) To investigate the effect of Smchd1 ablation on clustered Pcdh and Hox genes, we generated ChIP-seq profiles of EZH2 in clonal neural progenitor cells (NPCs) from Smchd1+/+ (wild-type, WT) and Smchd1-/- mouse embryonic stem (ES) cells. We also reanalyzed previously published Hi-C data (GSE99991) (Wang et al., 2018, Cell) in these two cell lines.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL17021
2 Samples

Download data: BW

Series

Accession:: GSE126257

ID:: 200126257

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001886866.

Epigenetic modifier Smchd1 maintains a normal pool of long-term repopulating hematopoietic stem cells in mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
19 Samples

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Series

Accession:: GSE188686

ID:: 200188686

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Select item 2001886857.

Epigenetic modifier Smchd1 maintains a normal pool of long-term repopulating hematopoietic stem cells in mice II

(Submitter supplied) We have used a conditional mouse model to investigate the role of Smchd1 specifically in hematopoiesis. We found that Smchd1-deleted mice have an altered hematopoietic stem and progenitor cell (HSPC) compartment with reduced repopulating capacity in competitive bone marrow transplantation assays and the gradual loss of adult hematopoietic stem cells (HSCs) with age, suggesting a role for Smchd1 in the maintenance of long-term adult HSCs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
18 Samples

Download data: CSV, TXT

Series

Accession:: GSE188685

ID:: 200188685

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Select item 2001885178.

Epigenetic modifier Smchd1 maintains a normal pool of long-term repopulating hematopoietic stem cells in mice I

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
1 Sample

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Series

Accession:: GSE188517

ID:: 200188517

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000657499.

Genome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL13112
34 Samples

Download data: TXT

Series

Accession:: GSE65749

ID:: 200065749

PubMed Full text in PMC Similar studies

Select item 20006574810.

Genome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation [ChIP-Seq, MBD-Seq]

(Submitter supplied) Purpose: The aim of this study is (1) to identify the chromatin occupancy of the epigenetic regulator Smchd1 in neural stem cells (NSCs) derived from E14.5 mouse brain; (2) to profile key epigenetic marks H3K4me3, H3K27me3 and DNA methylation in wild type and Smchd1 null NSCs; (3) to identify the chromatin occupancy of Ctcf in wild type and Smchd1 null NSCs. Methods: Chromatin immunoprecipitation for Smchd1, H3K4me3, H3K27me3 and Ctcf was performed essentially as in (Nelson et al. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL13112
28 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE65748

ID:: 200065748

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006574711.

Genome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation [RNA-Seq]

(Submitter supplied) Purpose: The aim of this study is to identify genes that are under the transcriptional control of the epigenetic regulator Smchd1 in neural stem cells (NSCs) derived from E14.5 mouse brain Methods: Total RNA was extracted using an AllPrep DNA/RNA Mini Kit (Qiagen) from cultured neural stem cells derived from male mouse E14.5 brains either wild-type or null for Smchd1. 1 µg total RNA was used to generate sequencing libraries for whole transcriptome analysis with Illumina’s TruSeq RNA Sample Preparation Kit v2 as per standard protocols. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE65747

ID:: 200065747

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004099212.

The effect on gene expression of Smchd1 deletion in various cell types

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
60 Samples

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Series

Accession:: GSE40992

ID:: 200040992

Select item 20004088113.

The effect on gene expression of Smchd1 deletion in premalignant pre-B cells

(Submitter supplied) Smchd1 appears to act as a tumour suppressor in the Eµ-Myc B cell lymphoma model. We find gene expression differences are most pronounced in premalignant cells. We always detect a small number of clustered genes and imprinted genes as differentially expressed, along with others involved in tumorigenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
12 Samples

Download data: TXT

Series

Accession:: GSE40881

ID:: 200040881

Select item 20004088014.

The effect on gene expression of Smchd1 deletion in end stage lymphomas

(Submitter supplied) Smchd1 appears to act as a tumour suppressor in the Eµ-Myc B cell lymphoma model. We find gene expression differences are most pronounced in the premalignant cells, and observe more variability in end stage lymphomas. We always detect a small number of clustered genes and imprinted genes as differentially expressed, along with others involved in tumorigenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
12 Samples

Download data: TXT

Series

Accession:: GSE40880

ID:: 200040880

Select item 20004087915.

The effect on gene expression of Smchd1 deletion in pre-B cells from E17.5 Eµ-Myc embryos

(Submitter supplied) Smchd1 appears to act as a tumour suppressor in the Eµ-Myc mouse B cell lymphoma model. We find a small number of gene expression differences at E17.5 in the pre-B cells, before phenotypic differences are observed.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
6 Samples

Download data: TXT

Series

Accession:: GSE40879

ID:: 200040879

Select item 20004073416.

The effect on gene expression of Smchd1 deletion in primary MEFs, transformed MEFs and MEF tumours

(Submitter supplied) Smchd1 appears to act as a tumour suppressor in the transformed fibroblast model. We find gene expression differences are most pronounced in the transformed MEFs. We always detect a small number of clustered genes and imprinted genes as differentially expressed, along with others involved in tumorigenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
30 Samples

Download data: TXT

Series

Accession:: GSE40734

ID:: 200040734

Select item 20011209717.

Role of SmcHD1 in the establishment of the epigenetic states required for the maintenance of X chromosome inactivation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11002 GPL18480
8 Samples

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Series

Accession:: GSE112097

ID:: 200112097

PubMed Similar studies

Select item 20011209618.

Role of SmcHD1 in the establishment of the epigenetic states required for the maintenance of X chromosome inactivation [ChIP-seq]

(Submitter supplied) It has been shown that functional deficiency of SmcHD1, a noncanonical member of SMC family proteins, results in derepression of X-inactivated genes in postimplantation female mouse embryos. In this study, we found that derepression of X-inactivated genes accompanied a local reduction in the enrichment of H3K27me3 in mouse embryonic fibroblasts (MEFs) prepared from female fetuses deficient for SmcHD1.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
4 Samples

Download data: TXT

Series

Accession:: GSE112096

ID:: 200112096

PubMed Similar studies SRA Run Selector

Select item 20011209519.

Role of SmcHD1 in the establishment of the epigenetic states required for the maintenance of X chromosome inactivation [RNA-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18480
4 Samples

Download data: TXT

Series

Accession:: GSE112095

ID:: 200112095

PubMed Similar studies SRA Run Selector

Select item 20009293620.

Roles of Structural maintenance of chromosome flexible domain containing 1 (Smchd1) in early lineage formation and development in mice

(Submitter supplied) The function of Structural maintenance of chromosome flexible domain containing 1 (Smchd1) was examined during mouse preimplantation development using an siRNA knockdown approach. Transient SMCHD1 deficiency during the period between fertilization and morula/early blastocyst stage compromised embryo viability and resulted in reduced cell number, reduced embryo diameter, and reduced nuclear volumes at the morula stage. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
10 Samples

Download data: DIFF, TXT

Series

Accession:: GSE92936

ID:: 200092936

PubMed Full text in PMC Similar studies SRA Run Selector

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