GEO DataSets

(Submitter supplied) In this study, we have tested the variation in gene expression signatures in human injured meniscus with age and degree of chondrosis in the knee. We found several genes that were differentially regulated with each of these factors and they represent important biological pathways in osteoarthritis research.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

12 Samples

Download data: TXT

(Submitter supplied) Objectives: To identify novel gene transcripts and biological processes in meniscus from patients with and without osteoarthritis (OA). Methods: We used microarrays to identify gene transcripts differentially expressed in meniscus tissues obtained from OA and non-OA patients (N=12 each). Real-time PCR was performed on selected gene transcripts. Biological processes and gene networking was examined computationally. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20844

24 Samples

Download data: TXT

(Submitter supplied) Objective: To examine the changes in tibial plateau cartilage in relation to body mass index (BMI) in patients with end-stage osteoarthritis (OA). Design: Knees were obtained from 23 OA patients (3 non-obese, 20 obese) at the time of total knee replacement. RNA prepared from cartilage was probed for differentially expressed (DE) gene transcripts using RNA microarrays and validated via real-time PCR. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16686

46 Samples

Download data: CEL, CHP

(Submitter supplied) Objective: The etiology of PCOS is mostly unknown. Existing data support both genetic and environmental factors in its pathogenesis. Design: Prospective case - control study. Setting: University Hospital. Patients: 25 patients undergoing IVF-ICSI treatment. Intervention: Genome-wide oligonucleotide microarray technology was used to study differential gene-expression patterns of cultured human cumulus cells from IVF patients divided into 4 groups according to disease state (PCOS vs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3841

Platform:

GPL570

23 Samples

Download data: CEL

Analysis of cumulus cells from lean and overweight-obese polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF). PCOS is a heterogeneous endocrinopathy in women of reproductive age, mostly associated with ovulation failure. Results provide insight into PCOS pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 2 other sets

Platform:

GPL570

Series:

GSE10946

23 Samples

Download data: CEL

(Submitter supplied) Anterior cruciate ligament (ACL) tears occur in isolation or in combination with other intra-articular injuries such as meniscus tears. The impact of injury pattern on the molecular biology of the injured ACL is unknown. Here, we tested the hypothesis that the biological response of the ACL to injury varies based on the presence or absence of concomitant meniscus tear. RNA-seq analysis was performed on 28 ACL tears remnants (12 isolated, 16 combined). more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21290

28 Samples

Download data: TXT

(Submitter supplied) We report on the application of RNA sequencing to study expression changes in cardiac surgery patients of different obesity categories.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

53 Samples

Download data: TXT

(Submitter supplied) This study was designed to identify the population of sperm RNAs responding to obesity as measured by BMI.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

32 Samples

Download data: TXT