GEO DataSets

(Submitter supplied) Transcriptional profiling of human lymphoblastoid cell lines with different ATM genotypes at basal level was compared to extract gene expression signatures that can identify ataxia telangiectasia (AT) carries from non AT carries and AT patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL887

24 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL887 GPL7260 GPL7264

88 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of human lymphoblastoid cell lines with different ATM genotypes 6h post sham- or 1.5 Gy IR-treatmentl was compared to extract IR-related gene expression signatures that can identify ataxia telangiectasia (AT) carries from non AT carries and AT patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL7264 GPL7260

64 Samples

Download data: TXT

(Submitter supplied) The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitivity to ionizing radiation (IR) and defects in DNA damage checkpoints. Profiles of global gene expression in AT cells were determined at 2, 6 and 24 h after treatment with 1.5 Gy IR or sham-treatment, and were compared to those previously recognized in normal human fibroblasts. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL885 GPL887

32 Samples

Download data: TXT

(Submitter supplied) Investigation of ATM-dependent and dose-dependent, or -independent, responses were examined in human lymphoblast cells 6 hr following exposure to either 1 or 5 Gy ionizing radiation. Keywords: cDNA, dual-channel

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2768 GPL2710

56 Samples

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(Submitter supplied) The DNA damage response network modulates a wide array of signaling pathways, including DNA repair, cell cycle checkpoints, apoptotic pathways and numerous stress signals. The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia (A-T), is a master regulator of this network when the inducing DNA lesions are double strand breaks. The ATM gene is also frequently mutated in sporadic cancers of lymphoid origin. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1544

Platform:

GPL81

14 Samples

Download data: CEL

Analysis of lymph nodes from ATM-deficient males exposed to ionizing radiation (IR). ATM regulates the cellular network induced by DNA double-strand breaks and is often mutated in lymphoid tumors. Results identify parallel induction of ATM-dependent pro- and antiapoptotic signals in response to IR.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 stress, 3 time sets

Platform:

GPL81

Series:

GSE2118

14 Samples

Download data: CEL

(Submitter supplied) af51_atm - sade-catma - which Arabidopsis thaliana genes are induced by ionising radiations? Comparison of SADE transcriptome data (Af1999083) and micro-arrays transcriptome data. - gamma rays irradiated vs non irradiated 4 days old seedlings Keywords: treated vs untreated comparison

Organism:

Arabidopsis thaliana

Type:

Expression profiling by array

Platform:

GPL5337

6 Samples

Download data: GPR

(Submitter supplied) af51_atm - atm-root - which Arabidopsis thaliana genes are induced by ionising radiations? Comparison of SADE transcriptome data (Af1999083) and micro-arrays transcriptome data. - Gamma rays irradiated vs non irradiated 3 or 4-days old seedlings Keywords: treated vs untreated comparison

Organism:

Arabidopsis thaliana

Type:

Expression profiling by array

Platform:

GPL5337

12 Samples

Download data: GPR

(Submitter supplied) af51_atm - atm time course - which Arabidopsis thaliana genes are induced by ionising radiations? Comparison of SADE transcriptome data (Af1999083) and micro-arrays transcriptome data. - which Arabidopsis thaliana genes are induced by ionising radiations ? time course: 0.75h, 1.5h, 3h, 5h dose: Gamma rays irradiated vs non irradiated 4-days old seedlings Keywords: time course

Organism:

Arabidopsis thaliana

Type:

Expression profiling by array

Platform:

GPL5337

20 Samples

Download data: GPR

(Submitter supplied) Genotoxic damage is known to disrupt cellular functions and is lethal if not repaired properly. We compare the transcriptional programs activated in response to genotoxic DNA damage induced by ionizing radiation (IR) in pre-B cells from mice deficient in various DNA damage response (DDR) genes. We used microarrays to detail the global gene expression of mutated cells compared to WT cells, with and without exposure to the DNA damaging agent ionizing radiation (IR), and identified differentially-regulated genes and associated pathways responding to the damage.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

42 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

synthetic construct; Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL19117 GPL17692

28 Samples

Download data: CEL

(Submitter supplied) Human induced pluripotent stem cells (hiPSCs) possess the ability to differentiate into chondrocytes and produce cartilaginous matrix without the need to biopsy healthy cartilage. However, this strategy is not without risk given that those transplanted cells can be subjected to IR during Head and Neck (H&N) (re-)treatment. The main aim of this study was to investigate the microRNA expression profile after ionizing radiation (IR) treatment of chondrocyte-like cells differentiated from hiPSCs. more...

Organism:

synthetic construct; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL19117

12 Samples

Download data: CEL

(Submitter supplied) Human induced pluripotent stem cells (hiPSCs) possess the ability to differentiate into chondrocytes and produce cartilaginous matrix without the need to biopsy healthy cartilage. However, this strategy is not without risk given that those transplanted cells can be subjected to IR during Head and Neck (H&N) (re-)treatment. The main aim of this study was to investigate the gene expression profile. The differentiated hiPSC into chondrocyte were irradiated in accordance with conventional therapy, hypofractionation and hyperfractionation protocols (1, 2, 3 Gy) intended for larynx region. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17692

16 Samples

Download data: CEL

(Submitter supplied) Peripheral blood lymphocytes from a total of 15 healthy individuals without history of cancer (NoCa) were immortalized with Epstein-Barr virus. Cells were exposed to mock treatment (Mock), ultra-violet radiation (UV), or ionizing radiation (IR). For UV radiation treatment, cells were exposed to 10 J/m^2 and harvested for RNA 24 hours later. For IR treatment, cells were exposed to 5 Gy of IR and harvested for RNA 4 hours later. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS913

Platform:

GPL8300

45 Samples

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Analysis of peripheral blood lymphocytes exposed to ultraviolet (10 J/m^2) or ionizing radiation (5 Gy). Lymphocytes obtained from 15 healthy individuals from ages 21 to 36 years and immortalized with Epstein-Barr virus. Results provide insight into transcriptional response to DNA damage.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent, 15 individual sets

Platform:

GPL8300

Series:

GSE1977

45 Samples

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