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Links from GEO DataSets

Items: 14

1.

Ethanol effect on myoblast differentiation

(Submitter supplied) Expression profiling of C2C12 myoblast cells treated with ethanol during differentiation. Ethanol inhibits C2C12 differentiation. Results provide insight into signaling pathways altered by ethanol during differentiation.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5370
Platform:
GPL6885
24 Samples
Download data: TXT
Series
Accession:
GSE46492
ID:
200046492
2.
Full record GDS5370

Ethanol effect on myoblast differentiation in vitro

Analysis of C2C12 cells cultured for up to 3 days in differentiation medium containing ethanol. Chronic alcoholics suffer from weakness and locomotor difficulty resulting from muscle damage. Results provide insight into the signaling pathways affected by ethanol in differentiating myoblasts.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 4 time sets
Platform:
GPL6885
Series:
GSE46492
24 Samples
Download data
3.

Guanidineacetic acid regulate myogenic differentiation through miR-133a-5 and miR-1a-3p co-mediated PI3K-Akt-mTOR signaling pathway

(Submitter supplied) Through small RNA sequencing, we finded that a total of 8 miRNAs, including miR-133a-3p and miR-1a-3p cluster, showed differential expression after guanidineacetic acid supplement. To further study the function of miR-133a-3p and miR-1a-3p in guanidineacetic acid induce myotube hypertrophy, we transfected miR-133a-3p and miR-1a-3p mimics, that also induce myotube hypertrophy. Through bioinformatics and dual-luciferase reporter system, the target gene of miR-133a-3p and miR-1a-3p were respectively determined. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE118528
ID:
200118528
4.

Rexinoid signalling during early myogenic differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL13112
27 Samples
Download data: BEDGRAPH, FPKM_TRACKING
Series
Accession:
GSE94561
ID:
200094561
5.

RNA-seq profiling of rexinoid responsive gene expression during early myogenic differentiation

(Submitter supplied) While skeletal myogenesis is tightly coordinated by myogenic regulatory factors including MyoD and myogenin, chromatin modifications have emerged as vital mechanisms of myogenic regulation. We have previously established that bexarotene, a clinically approved agonist of retinoid X receptor, promotes the specification and differentiation of skeletal muscle lineage. Here, we examine a genome-wide impact of rexinoids on myogenic differentiation through integral RNA-seq and ChIP-seq analyses. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
10 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE94560
ID:
200094560
6.

ChIP-seq profiling of histone modifications and retinoid X receptor occupancy during early myogenic differentiation

(Submitter supplied) While skeletal myogenesis is tightly coordinated by myogenic regulatory factors including MyoD and myogenin, chromatin modifications have emerged as vital mechanisms of myogenic regulation. We have previously established that bexarotene, a clinically approved agonist of retinoid X receptor, promotes the specification and differentiation of skeletal muscle lineage. Here, we examine a genome-wide impact of rexinoids on myogenic differentiation through integral RNA-seq and ChIP-seq analyses. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
17 Samples
Download data: BEDGRAPH
Series
Accession:
GSE94558
ID:
200094558
7.

Gene expression profile upon IL-22 stimulation, forced expression of Hes1, or IL-22 stimulation under forced expression of Hes1, in human colon carcinoma-derived LS174T cells

(Submitter supplied) A human colon carcinoma-derived cell line LS174T was modified to overexpress Hes1, a bHLH-type transcription factor, upon doxycycline addition (designated as LS174T-tetON-Hes1 cells), using the T-rex system (Invitrogen). We have previously shown that these cells can overexpress Hes1 under the control of CMV promoter (Zheng et al, Inflamm Bowel Dis, 17;2251-2260, 2011), and the amont of the overexpressed Hes1 protein reaches to the maximal level in early as 3 hours from doxycycline addition (100ng/ml), which persists for up to 24 hours. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13915
3 Samples
Download data: TXT
Series
Accession:
GSE43012
ID:
200043012
8.

miR-487b, miR-3963 and miR-6412 delayed myogenic differentiation in C2C12 mouse myoblast-derived cells.

(Submitter supplied) We newly identified skeletal muscle differentiation-associated miRNAs by comparing miRNA expression profile between C2C12 cell and Wnt4-overexpressing C2C12 cell. miR-487b, miR-3963 and miR-6412 are significantly down-regulated in differentiating C2C12 cells, and transfection of their mimics resulted in reduced expression of myogenic differentiation markers including Troponin T, myosin heavy chain fast and slow type.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL18466
3 Samples
Download data: TXT
Series
Accession:
GSE63454
ID:
200063454
9.

Effect on small molecule RBPJ inhibitor (RIN1) on gene expression in Jurkat cells compared to gamma secretase inhibition and siRNA knockdown of RBPJ

(Submitter supplied) We discovered a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ, which is the main transcriptional effector of NOTCH signaling. RBPJ Inhibitor-1 (RIN1) also blocked the functional interaction of RBPJ with SHARP, a scaffold protein that forms a transcriptional repressor complex with RBPJ in the absence of NOTCH signaling. RIN1 induced changes in gene expression resembled siRNA silencing of RBPJ rather than inhibition at the level of NOTCH itself. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
14 Samples
Download data: TXT
Series
Accession:
GSE134401
ID:
200134401
10.

Transcriptome analysis of the differentiated C2C12 cells in 3 different substrate, Tissue culture plate, Methacarylated gelatin and 15% Methacarylated gelatin mixed with 1% PSS (poly sodium 4-styrenesulfonate)

(Submitter supplied) Purpose : To determine transcriptome profile of the diffferentiated C2C12 cells in 3 different cell culture substrate, Tissue culture plate, Methacarylated gelatin and 15% Methacarylated gelatin mixed with 1% PSS (poly sodium 4-styrenesulfonate) Method : RNA smples prepared from differentiated C2C12 cells in 3 different cell culture substrate, Tissue culture plate, Methacarylated gelatin and 15% Methacarylated gelatin mixed with 1% PSS (poly sodium 4-styrenesulfonate) Results : Paired-ends 101bp reads, we mapped about 72 million reads - 145 million reads per sample to the mouse genome (build mm10) and assembled with cufflinks program (value : FPKM)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
3 Samples
Download data: TXT
Series
Accession:
GSE165480
ID:
200165480
11.

Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL4134 GPL9250 GPL9115
22 Samples
Download data: TXT, WIG
Series
Accession:
GSE21621
ID:
200021621
12.

Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity: ChIP-Seq

(Submitter supplied) Smad3 co-occupies DNA binding sites with master transcription factors.
Organism:
Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9250 GPL9115
21 Samples
Download data: TXT, WIG
Series
Accession:
GSE21614
ID:
200021614
13.

ChIP-seq profiling of myogenin and p300 occupancy in the context of rexinoid signaling during early myogenic differentiation

(Submitter supplied) Deciphering the molecular mechanisms underpinning myoblast differentiation is a critical step in developing the best strategy to promote muscle regeneration in patients suffering from muscle-related diseases. We have previously established that a rexinoid x receptor (RXR)-selective agonist enhances the differentiation and fusion of myoblasts through a direct regulation of MyoD expression, coupled with an augmentation of myogenin protein. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL13112 GPL17021 GPL21103
8 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE139942
ID:
200139942
14.

STAC3 is required for myotube formation and myogenic differentiation in vertebrate skeletal muscle

(Submitter supplied) STAC3 was identified as a nutritionally regulated gene from an Atlantic salmon subtractive hybridization library with highest expression in skeletal muscle. Salmon STAC3 mRNA was highly correlated with myogenin and myoD1a expression during differentiation of a salmon primary myogenic culture and was regulated by amino acid availability. In zebrafish embryos, STAC3 was initially expressed in myotomal adaxial cells and in fast muscle fibres post-segmentation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
18 Samples
Download data: TXT
Series
Accession:
GSE34474
ID:
200034474
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