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Links from GEO DataSets

Items: 20

1.

The effect of short term Rapamycin on the transcriptome of old mouse liver

(Submitter supplied) Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin short term (6 months) Rapamycin from 19 months of age.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
42 Samples
Download data: TXT
Series
Accession:
GSE48331
ID:
200048331
2.

The effect of Rapamycin on the transcriptome of old mouse liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
111 Samples
Download data
Series
Accession:
GSE48334
ID:
200048334
3.

The effect of chronic Rapamycin on the transcriptome of old mouse liver

(Submitter supplied) Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin chronically (21 months) from 4 months of age.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
69 Samples
Download data: TXT
Series
Accession:
GSE48333
ID:
200048333
4.

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

(Submitter supplied) Rapamycin (Rapa) and dietary restriction (DR) have consistently been shown to increase lifespan. To investigate whether Rapa and DR affect similar pathways in mice, we compared the effects of feeding mice ad libitum (AL), Rapa, DR, or a combination of Rapa and DR (Rapa + DR) on the transcriptome and metabolome of the liver. The principal component analysis shows that Rapa and DR are distinct groups. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
46 Samples
Download data: TXT
Series
Accession:
GSE40977
ID:
200040977
5.

Short-term rapamycin treatment in mice have few effects on the transcriptome of white adipose tissue compared to dietary restriction

(Submitter supplied) Analysis of the transcriptome in the epididymal fat of young mice (8 months of age) from treatment of dietary restriction, or rapamycin
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
24 Samples
Download data: TXT
Series
Accession:
GSE52825
ID:
200052825
6.

Identification and application of gene expression signatures associated with lifespan extension

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL24247
102 Samples
Download data
Series
Accession:
GSE131901
ID:
200131901
7.

RNA sequencing of mouse hepatic response to compounds with predicted lifespan-extending effect

(Submitter supplied) This dataset consists of hepatic gene expression profiles of mice subjected to 4 compounds predicted by Connectivity Map (CMap) using gene signatures identified for known lifespan-extending interventions: ascorbyl-palmitate, KU-0063794, AZD8055 and rilmenidine. Corresponding age-, sex- and strain-matched littermate controls are also presented. Using this data, we confirmed the association between longevity signatures and gene expression response to the predicted compounds in vivo, using the same mouse model as for the identification of gene signatures associated with lifespan extension. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
24 Samples
Download data: TXT
Series
Accession:
GSE131868
ID:
200131868
8.

RNA sequencing of mouse hepatic response to lifespan-extending interventions

(Submitter supplied) This dataset consists of hepatic gene expression profiles of mice subjected to 8 different lifespan-extending interventions, together with the corresponding age-, sex- and strain-matched littermate controls: caloric restriction (CR), methionine restriction (MR), growth hormone receptor knockout (GHRKO), Snell dwarf mice (Pit1 -/-), rapamycin, acarbose, 17-alpha-estradiol (17aE2) and Protandim. Both sexes and different age groups are presented within dataset. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
78 Samples
Download data: TXT
Series
Accession:
GSE131754
ID:
200131754
9.

Rapamycin extends life span, but has limited effects on aging in mice

(Submitter supplied) Rapamycin extends life span in mice, but it remains unclear if this compound also delays mammalian aging. Here, we present results from a comprehensive large-scale assessment of a wide rage of structural and functional aging phenotypes in mice. Rapamycin extended life span but showed few effects on a large number of systemic aging phenotypes, suggesting that rapamycin's effects on aging are largely limited to the regulation of age-related mortality and carcinogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
30 Samples
Download data: TXT
Series
Accession:
GSE41018
ID:
200041018
10.

Late life rapamycin treatment reverses age-related heart dysfunction

(Submitter supplied) We report the mRNA profile of aged mice (24 months old) fed either a control diet or a diet containing Rapamycin (14 ppm) for 3 months. After drug treatement, the hearts of the mice were removed and total mRNA was removed from the tissue. Analysis revealed that there were 700 significantly differentially expressed genes between the control fed group and the Rapamycin diet group by our analysis.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
20 Samples
Download data: TXT
Series
Accession:
GSE48043
ID:
200048043
11.

Regulation of Rat Hepatic Translation by mTOR

(Submitter supplied) Our strategy was to manipulate mTOR signaling in vivo, then characterize the transcriptome and translating mRNA in liver tissue. In adult rats, we used the non-proliferative growth model of refeeding after a period of fasting, and the proliferative model of liver regeneration following partial hepatectomy. We also studied livers from pre-term fetal rats (embryonic day 19-20) in which fetal hepatocytes are asynchronously proliferating. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
40 Samples
Download data: CEL
Series
Accession:
GSE67022
ID:
200067022
12.

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL21103 GPL19057
48 Samples
Download data: TXT
Series
Accession:
GSE89275
ID:
200089275
13.

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions (WGBS 2)

(Submitter supplied) Investigation into changes in the methylome in rapamycin and caloric restriction in aged mice.
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL21103
16 Samples
Download data: TXT
Series
Accession:
GSE89274
ID:
200089274
14.

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions (RNA-Seq)

(Submitter supplied) Investigation into changes in the methylome in young (2 months) and aged (22 months) Ames dwarf (Prop1 Hom) and WT (Prop1 Het) mice
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
16 Samples
Download data: CSV
Series
Accession:
GSE89272
ID:
200089272
15.

Calorie Restriction Feminizes Liver Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

(Submitter supplied) Background: Calorie restriction (CR) is the only intervention known to extend lifespan in a wide range of organisms, including mammals. However, the mechanisms by which it regulates mammalian aging remain largely unknown and the involvement of the TOR and Sirtuin pathways (which regulate aging in lower organisms) remain controversial. Femaleness is a second phenotype generally associated with longevity but the relationship between sex-biased and CR-induced gene expression remains undetermined. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6761
23 Samples
Download data: GPR
Series
Accession:
GSE11244
ID:
200011244
16.

Identification of Novel Targets of Diabetic Nephropathy Using RNA-seq

(Submitter supplied) Diabetic nephropathy (DN) is a major complication of type 1 and type 2 diabetes and may lead to kidney failure. Understanding how diabetes regulates transcriptome dynamics in DN is important for understanding the biology of the disease and for guiding development of new treatments. In this study, we identified a set of unique biomarkers and canonical pathways that may hold the key to understanding mechanisms of DN pathobiology with value for clinical translation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: TXT
Series
Accession:
GSE87899
ID:
200087899
17.

Gene expression profile from short-term caloric restriction in mouse adipose tissue

(Submitter supplied) To provide a robust understanding of a transcriptomic change by short-term CR at body fat of mice, we applied three serial strengths of CR to mice including 15%, 30%, and 45% reduction of carbon source. Using Affymetrix mouse 1.0 ST array platform, we obtained and analyzed the transcriptome data for significantly changed genes in expression. Here, we identified 446 genes and categorized the genes based on their biological roles. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE60596
ID:
200060596
18.

Murine Spermatogonial Stem Cells: Rapamycin- vs Vehicle-exposed in vivo (2-wk treatment)

(Submitter supplied) Male FVB strain mice aged 12-days-old through 26-days-old were administered daily intraperitoneal injections of rapamycin (4mg/kg body weight) or control vehicle (5% Tween-80, 5% PEG-400), beginning at postnatal day (P)12. Mice were euthanized at P26 and their testes were isolated for germ cell enrichment. Single cell suspensions of germ cells were prepared from isolated testes and subjected to magnetic-activated cell sorting (MACS). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
1 Sample
Download data: TXT
Series
Accession:
GSE37062
ID:
200037062
19.

Characterization of T-rapamycin cells by gene expression profiling

(Submitter supplied) Gene expression profiling of CD4+ T cells cultured in vitro in presence of IL-2, IL-4, Rapamycin for 12 days Sources tested: Day 0 CD4+ T cells (6 samples), Day 6 T-rapamycin cells (6 samples), Day 12 T-rapamycin cells (6 samples)
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
18 Samples
Download data: TXT
Series
Accession:
GSE34911
ID:
200034911
20.

Expression profiling of the effect of high-fat diet, low-fat diet, CR and exercise on mice liver

(Submitter supplied) Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging process. We found that pathways transcriptionally correlated with diet-modulated lifespan and physiological changes were enriched for lifespan-modifying genes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
18 Samples
Download data: CEL
Series
Accession:
GSE36838
ID:
200036838
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