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Links from GEO DataSets

Items: 20

1.

Alveolar Macrophage Gene Expression in Human Pulmonary Fibrosis

(Submitter supplied) Gene expression profiles for patients affected with Sporadic and Familial Pulmonary Fibrosis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
84 Samples
Download data: CEL
Series
Accession:
GSE49072
ID:
200049072
2.

Development and Preclinical Efficacy of Novel Transforming Growth Factor-β1 (TGFβ1) siRNAs for Pulmonary Fibrosis

(Submitter supplied) Idiopathic pulmonary fibrosis is a chronic devastating disease of unknown etiology. No therapy is currently available. A growing body of evidence supports the role of TGFβ1 as the major player in the pathogenesis of the disease. This study designed novel human- and mouse-specific siRNAs and siRNA/DNA chimeras targeting both human and mouse common sequences and evaluated their inhibitory activity in pulmonary fibrosis induced by bleomycin and lung-specific transgenic expression of human TGFβ1. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13285
9 Samples
Download data: GPR
Series
Accession:
GSE28122
ID:
200028122
3.

Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles (miRNA-Seq)

(Submitter supplied) We studied transcriptomic changes of extracellular vesicles (EVs) in bronchoalveolar lavage fluid of bleomycin-injured wild-type and syndecan-1 deficient mice
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
16 Samples
Download data: XLSX
Series
Accession:
GSE134948
ID:
200134948
4.

Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles (RNA-Seq)

(Submitter supplied) We evaluted the effects of extracellular vesicles of bleomycin-injured wild-type and syndecan-1 deficient mice on mouse lung epithelial cell line (MLE-12) total transcriptomic changes (bulk mRNA sequencing)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
9 Samples
Download data: XLSX
Series
Accession:
GSE134741
ID:
200134741
5.

mouse lung single cell RNA-seq

(Submitter supplied) Single cell RNA-seq profiling adult mouse lung cells reveal the cell heterogeneity and mechanism during lung fibrosis process.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: H5
Series
Accession:
GSE131800
ID:
200131800
6.

Expression data from HFL-1 fibroblasts

(Submitter supplied) Hyaluronidases was reported to be effective in lung fibrosis therapy, and HYAL1 was found to inhibit TGF-β1 mediated cell growth in murine L929 fibroblasts, while the underlying mechanism of HYAL1 in regulating human lung fibroblasts is largely unknown. We used microarray to detail the gene expression of HYAL1 overexpression HFL-1 fibroblasts, and found significantly downregulated genes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15207
6 Samples
Download data: CEL
Series
Accession:
GSE131443
ID:
200131443
7.

Genetic modifier of TGF-beta1 stimulated pulmonayr fibrosis

(Submitter supplied) Expression profiling of pulmonayr fibrosis prone and fibrosis resistant strains of mice with transgenic overexpression of TGF-beta1
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE119662
ID:
200119662
8.

The antifibrotic activity of the selective IP receptor agonist ACT-333679 is mediated through inhibition of YAP/TAZ signaling

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a life-threatening and progressive scarring disease of the lung. Loss of alveolar epithelial cells, inflammation, activation of fibroblasts, appearance of myofibroblasts and excessive deposition of extracellular matrix (ECM) are central features of IPF pathogenesis, ultimately resulting in changes in tissue architecture and lung dysfunction. The two currently approved therapies, pirfenidone (Esbriet®) and nintedanib (Ofev®), significantly slow the rate of disease progression, but they do not halt or reverse tissue remodeling. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21185
16 Samples
Download data: TXT
Series
Accession:
GSE109585
ID:
200109585
9.

Antifibrotic effect of metformin in the lung

(Submitter supplied) This experiment includes treatment of human pulmonary fibroblasts obtained from IPF patients with metformin. Since, we would like to investigate the transcriptome profile of these samples following metformin treatment. There will be two groups consist of four samples each. First group treated with metformin for 72 hours, while the second group treated with vehicle.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL20844
7 Samples
Download data: GPR
Series
Accession:
GSE131133
ID:
200131133
10.

Real-time quantitative PCR analysis of murine bone marrow cells

(Submitter supplied) TGF-β1 signaling pathway of bone marrow of the Gata1low mouse model of myelofibrosis
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL16739
4 Samples
Download data: TXT
Series
Accession:
GSE44797
ID:
200044797
11.

Real-time quantitative PCR analysis of spleen cells

(Submitter supplied) TGF-β1 signaling pathway of spleen of the Gata1low mouse model of myelofibrosis
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL16739
4 Samples
Download data: TXT
Series
Accession:
GSE44795
ID:
200044795
12.

Gene expression data from bleomycin-instilled lung tissue or control (Sham) of C57BL/6 mice (wild-type mice and transgenic mice expressing dominant-negative form of p38α or constitutive active form of MKK6 in type II alveolar epithelial cells).

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a type of pulmonary fibrosis, a disease that results in scarring and stiffness of lung tissue affecting over 5 million people globally, while the underlying disease mechanisms in IPF are largely unknown. As an animal model of IPF, a single intratracheal injection of bleomycin (BLM) is generally employed, in which cell death of type II alveolar epithelial cells (AEC II) is a trigger of pulmonary fibrosis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
18 Samples
Download data: XLSX
Series
Accession:
GSE154074
ID:
200154074
13.

Role of Gq/11 and G12/13 signalling in Type II alveolar epithelial cells

(Submitter supplied) We have used microarrays to identify individual genes and pathways regulated by Gq/11 or G12/13 signalling in type II alveolar epithelial cells isolated from the lungs of knockout mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE87842
ID:
200087842
14.

Pretreatment of aged mice with retinoic acid restores alveolar regeneration via upregulation of reciprocal PDGFRA signaling

(Submitter supplied) Reciprocal PDGFA signaling activates regenerative fibroblasts that support alveolar epithelial cell differentiation and repair, providing a potential therapeutic strategy to influence the pathogenesis of IPF.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL17021
21 Samples
Download data: TXT
Series
Accession:
GSE157440
ID:
200157440
15.

RNA quantitative sequencing in TGF-beta treated PDCD5 knockdown C22 cells

(Submitter supplied) The role of bronchial epithelial club (clara) cell in lung fibrosis is unclear. We found programmed cell death 5 (PDCD5) expression is elevated in lung fibrosis. To investigate the molecular mechanism by which PDCD5 mediates lung fibrosis in club cell, mouse C22 cells were analyzed by RNA-sequencing with or without Pdcd5 knockdown after TGF-beta treatment.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: TXT
Series
Accession:
GSE143841
ID:
200143841
16.

Transforming growth factor beta 1 induces methylation changes in lung fibroblasts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Idiopathic pulmonary fibrosis (IPF) is a complex disease of unknown etiology. Environmental factors can affect disease susceptibility via epigenetic effects. Few studies explore global DNA methylation in lung fibroblasts, but none have focused on transforming growth factor beta-1 (TGF-b1) as a potential modifier of the DNA methylome. Here we analyzed changes in methylation and gene transcription in normal and IPF fibroblasts following TGF-b1 treatment.
Organism:
Homo sapiens
Type:
Expression profiling by array; Methylation profiling by genome tiling array
Platforms:
GPL13534 GPL15207
30 Samples
Download data: CEL, IDAT
Series
Accession:
GSE135099
ID:
200135099
17.

Transforming growth factor beta 1 induces methylation changes in lung fibroblasts [Illumina]

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a complex disease of unknown etiology. Environmental factors can affect disease susceptibility via epigenetic effects. Few studies explore global DNA methylation in lung fibroblasts, but none have focused on transforming growth factor beta-1 (TGF-b1) as a potential modifier of the DNA methylome. Here we analyzed changes in methylation and gene transcription in normal and IPF fibroblasts following TGF-b1 treatment.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
12 Samples
Download data: IDAT
Series
Accession:
GSE135097
ID:
200135097
18.

Transforming growth factor beta 1 induces methylation changes in lung fibroblasts [Affymetrix]

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a complex disease of unknown etiology. Environmental factors can affect disease susceptibility via epigenetic effects. Few studies explore global DNA methylation in lung fibroblasts, but none have focused on transforming growth factor beta-1 (TGF-b1) as a potential modifier of the DNA methylome. Here we analyzed changes in methylation and gene transcription in normal and IPF fibroblasts following TGF-b1 treatment.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15207
18 Samples
Download data: CEL
Series
Accession:
GSE135065
ID:
200135065
19.

Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis II

(Submitter supplied) Pulmonary fibrosis is a heterogeneous syndrome in which fibrotic scar replaces normal lung tissue. We performed massively parallel single-cell RNA-Seq on lung tissue from eight lung transplant donors and eight patients with pulmonary fibrosis. Combined with in situ RNA hybridization, with amplification, these data provide a molecular atlas of disease pathobiology. We identified a distinct, novel population of profibrotic alveolar macrophages exclusively in patients with fibrosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
17 Samples
Download data: H5
Series
Accession:
GSE122960
ID:
200122960
20.

Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis

(Submitter supplied) Pulmonary fibrosis is a heterogeneous syndrome in which fibrotic scar replaces normal lung tissue. We performed massively parallel single-cell RNA-Seq on lung tissue from eight lung transplant donors and eight patients with pulmonary fibrosis. Combined with in situ RNA hybridization, with amplification, these data provide a molecular atlas of disease pathobiology. We identified a distinct, novel population of profibrotic alveolar macrophages exclusively in patients with fibrosis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
2 Samples
Download data: H5, MTX, TSV
Series
Accession:
GSE121611
ID:
200121611
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