Similar studies for GEO DataSets (Select 200049279) - GEO DataSets

Type:: Expression profiling by array; Non-coding RNA profiling by high throughput sequencing; SNP genotyping by SNP array; Methylation profiling by genome tiling array; Genome binding/occupancy profiling by array

6 related Platforms
324 Samples

Download data: CEL

Series

Accession:: GSE49280

ID:: 200049280

Select item 2000492784.

Expression profiling by array of 44 adrenocortical carcinomas

(Submitter supplied) Gene expression profiles of adrenocortical carcinomas were analyzed using Affymetrix Human Gene 2.0 ST Array to identify homogeneous molecular subgroups

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
44 Samples

Download data: CEL

Series

Accession:: GSE49278

ID:: 200049278

Select item 2000492775.

Genome-scale methylome profiling of adrenocortical carcinomas (ACC) and adenomas (ACA)

(Submitter supplied) Genome-scale DNA methylation was analyzed in a cohort of ACC and ACA to identify DNA methylation changes.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL8490
81 Samples

Download data: TXT

Series

Accession:: GSE49277

ID:: 200049277

Select item 2000492766.

SNP data from 45 adrenocortical carcinomas

(Submitter supplied) SNP array data from 45 adrenocortical carcinomas were used to detect recurrent copy number alterations.

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platforms:: GPL13135 GPL8887
45 Samples

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Series

Accession:: GSE49276

ID:: 200049276

PubMed Similar studies

Select item 2001433857.

microRNA expression analysis of metastatic adrenocortical tumors

(Submitter supplied) Background: Adrenocortical carcinoma (ACC) is a rare, often-aggressive neoplasm of the adrenal cortex, with a 14.5-month median overall survival. We asked whether tumors from patients with advanced or metastatic ACC would offer clues as to putative genes that might have critical roles in disease progression or in more aggressive disease biology. Methods: We conducted comprehensive genomic and expression analyses, including microRNA profiling, of 33 ACCs and 6 normal adrenals. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL27982
39 Samples

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Series

Accession:: GSE143385

ID:: 200143385

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001433838.

Gene expression analysis of metastatic adrenocortical tumors

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16043
63 Samples

Download data: CEL, CHP

Series

Accession:: GSE143383

ID:: 200143383

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000284769.

Characterization of differential gene expression in adrenocortical tumors harbouring β-catenin (CTNNB1) mutations.

(Submitter supplied) Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes of CTNNB1 have not yet been identified in adrenocortical tumors. Our objective was to identify genes de-regulated in adrenocortical tumors harbouring CTNNB1 genetic alterations.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3912
Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE28476

ID:: 200028476

Select item 391210.

Adrenocortical adenomas harboring β-catenin gene CTNNB1 mutations

Analysis of adrenocortical adenomas (AA) with β-catenin missense mutations and AAs with wild-type CTNNB1. Mutations of CTNNB1 are common in AA and adrenocortical carcinomas (ACC). Results provide insight into molecular mechanisms deregulated in adrenocortical tumors with CTNNB1 genetic alterations.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 genotype/variation, 3 other, 2 tissue sets

Platform:: GPL570
Series:: GSE28476
8 Samples

Download data: CEL

DataSet

Accession:: GDS3912

ID:: 3912

Select item 20003506611.

SNP array profiling of childhood adrenocortical tumours reveals distinct pathways of tumourigenesis and highlights candidate driver genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platforms:: GPL6986 GPL6985 GPL8887
31 Samples

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Series

Accession:: GSE35066

ID:: 200035066

PubMed Similar studies

Select item 20003506412.

SNP data from 12 childhood adrenocortical tumors from outside Brazil

(Submitter supplied) SNP array data from 12 childhood adrenocortical tumors (ACT) were used to identify recurrent chromosome rearrangements and candidate driver genes.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platforms:: GPL6986 GPL8887
12 Samples

Download data: TXT

Series

Accession:: GSE35064

ID:: 200035064

PubMed Similar studies

Select item 20002480413.

SNP data from 13 childhood adrenocortical tumours from Brazilian patients and 6 matched normal samples

(Submitter supplied) SNP array data from 13 Brazilian childhood adrenocortical tumors (ACTs) were analyzed to detect recurrent copy number changes and highlight potential candidate driver genes.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platforms:: GPL6986 GPL6985
19 Samples

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Series

Accession:: GSE24804

ID:: 200024804

PubMed Full text in PMC Similar studies

Select item 20001492214.

Human Adrenocortical Tumors: normal cortex vs inactive adenoma vs cortisol secreting adenoma vs adrenocortical cancer

(Submitter supplied) Transcriptional profiling of human adrenocortical tumors. Gene expression profile of normal adrenal cortex, hormonally inactive adenoma, cortisol-secreting Cushing-adenoma and primary adrenocortical cancer tissues were compared. The goal of this study was to identify significant differences in the gene expression of these groups. Further aim was to reveal biologically relevant pathogenetic pathways altered at transcriptional and posttranscriptional level, as well.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
16 Samples

Download data: TXT

Series

Accession:: GSE14922

ID:: 200014922

Select item 20003337115.

Beta-catenin status effects in human adrenocortical carcinomas (33), adenomas (22), and normal adrenal cortex (10)

(Submitter supplied) We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples. We compared adrenocortincal carcinomas with and without abnormal beta-catenin staining and found many significant expression differences and significant results from enrichment testing. A similar comparison in the adenomas gave relatively few differences, and they did not correlate to differences found for the carcinomas. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
65 Samples

Download data: CEL, XLS

Series

Accession:: GSE33371

ID:: 200033371

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007787116.

Pathway implications of aberrant global methylation in adrenocortical cancer

(Submitter supplied) Context: Adrenocortical carcinomas (ACC) are a rare tumor type with a poor five-year survival rate and limited treatment options. Objective: Understanding of the molecular pathogenesis of this disease has been aided by genomic analyses highlighting alterations in TP53, WNT, and IGF signaling pathways. Further elucidation is needed to reveal therapeutically actionable targets in ACC. Design: In this study, global DNA methylation levels were assessed by the Infinium HumanMethylation450 BeadChip Array on 18 ACC tumors and 6 normal adrenal tissues. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
24 Samples

Download data: TXT

Series

Accession:: GSE77871

ID:: 200077871

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001977617.

Adrenocortical Carcinoma Gene Expression Profiling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL570 GPL887
63 Samples

Download data: CEL, TXT

Series

Accession:: GSE19776

ID:: 200019776

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001977518.

Adrenocortical Carcinoma Gene Expression Profiling [Agilent]

(Submitter supplied) Adrenocortical carcinoma (ACC) is an aggressive endocrine tumor with a poor 5 year survival rate of 10-20%. We used expression profiling to assess the transcriptional changes associated with ACC as compared to normal adrenal glands with the goal of identifying new targets for treatment. Fourteen ACC tumors were profiled on both Affymetrix U133 Plus 2 or Agilent 22K Human Genome arrays; an additional six tumors were profiled on one or the other array. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL887
15 Samples

Download data: TXT

Series

Accession:: GSE19775

ID:: 200019775

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001975019.

Adrenocortical Carcinoma Gene Expression Profiling [Affymetrix]

(Submitter supplied) Background: Adrenocortical carcinoma (ACC) is associated with poor survival rates. The objective of the study was to analyze ACC gene expression profiling data prognostic biomarkers and novel therapeutic targets. Methods: 44 ACC and 4 normal adrenal glands were profiled on Affymetrix U133 Plus 2 expression microarrays and pathway and transcriptional enrichment analysis performed. Protein levels were determined by western blot. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
48 Samples

Download data: CEL, TXT

Series

Accession:: GSE19750

ID:: 200019750

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003635320.

Genome wide DNA Methylation analysis of benign and malignant adrenocortical tumors

(Submitter supplied) Genome wide DNA methylation profiling of normal adrenocortical tissue, adrenocortical adenomas and adrenocortical carcinomas. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles. Samples included 6 normal adrenocortical tissue samples, 27 adenomas and 15 carcinomas.