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Links from GEO DataSets

Items: 16

1.

Expression data from the lungs of Scnn1b-Transgenic and wild-type mice

(Submitter supplied) Airway mucus obstruction triggers macrophage activation and MMP12-dependent emphysema
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE49373
ID:
200049373
2.

Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD

(Submitter supplied) Chronic obstructive pulmonary disease (COPD) is characterized by a progressive decline in lung function, caused by exposure to exogenous particles, mainly cigarette smoke (CS). COPD pathogenesis is initiated and perpetuated by an abnormal CS-induced inflammatory response of the lungs, involving both innate and adaptive immunity. Specifically, B cells organized in iBALT structures, as well as macrophages, accumulate in the lungs and contribute to CS-induced emphysema, but the mechanisms thereof remain unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5438
Platform:
GPL6885
12 Samples
Download data: TXT
Series
Accession:
GSE52509
ID:
200052509
3.
Full record GDS5438

Lung from cigarette smoke-related chronic obstructive pulmonary disease model: time course

Analysis of lung from cigarette smoke (CS)-treated C57BL/6N females at 4 and 6 months of age. Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD). Results provide insight into the molecular mechanisms underlying cigarette smoke-induced COPD.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 stress sets
Platform:
GPL6885
Series:
GSE52509
12 Samples
Download data
DataSet
Accession:
GDS5438
ID:
5438
4.

Transcriptional profle of bronchoalveolar cells in sarcoidosis

(Submitter supplied) Introduction: Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased approach to identify pathways activated in alveolar macrophages—a key immuno-inflammatory cell in the lung—can shed light on the pathogenesis of this complex disease. Methods: We recruited 15 patients with various stages of sarcoidosis and 12 healthy controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
27 Samples
Download data: CEL
Series
Accession:
GSE75023
ID:
200075023
5.

A Distinctive Alveolar Macrophage Activation State Induced by Cigarette Smoking

(Submitter supplied) This series represents alveolar macrophages from a mouse model of emphysema, deletion of the integrin beta6 Keywords: parallel sample
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1874
Platform:
GPL1792
15 Samples
Download data: TIFF
Series
Accession:
GSE2255
ID:
200002255
6.

isolated alveolar macrophages

(Submitter supplied) This series represents isolated alveolar macrophages from human subjects. Keywords: parallel sample
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1269
Platform:
GPL570
45 Samples
Download data: CEL
Series
Accession:
GSE2125
ID:
200002125
7.
Full record GDS1874

Integrin beta-6 deficiency model of emphysema: alveolar macrophage

Analysis of alveolar macrophages of integrin beta-6 (Itgb6) deficient animals treated with doxycycline. Itgb6 mutants develop emphysema. Effect of TGFbeta transgene induction to suppress the effect of the Itgb6 mutation also examined.
Organism:
Mus musculus
Type:
Expression profiling by array, log ratio, 3 genotype/variation sets
Platform:
GPL1792
Series:
GSE2255
15 Samples
Download data: TIFF
8.
Full record GDS1269

Cigarette smoking effect on alveolar macrophage

Analysis of alveolar macrophages from 15 cigarette smokers, 15 non-smokers and 15 asthmatics. Results suggest that alveolar macrophage activation induced by smoking contributes to emphysema.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent sets
Platform:
GPL570
Series:
GSE2125
45 Samples
Download data: CEL
9.

mRNA expression data from either wild-type mice or Scnn1b-transgenic mice at post-natal days 0, 3, 10, and 42

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6246 GPL11533
84 Samples
Download data: CEL
Series
Accession:
GSE47551
ID:
200047551
10.

mRNA expression data from whole trachea dissected from either wild-type mice or Scnn1b-Tg mice at post-natal days 0, 3, 10, and 42

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84; and Livraghi-Butrico et al. 2012, Mucosal Immunology 5(4):397-408). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE47550
ID:
200047550
11.

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; and Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84. Briefly, overexpression of the Scnn1b transgene in airway Club cells leads to hyperabsorption of sodium from the airway surface liquid, dehydrated airway surface liquid and mucus, and reduced mucus clearance associated with accumulation of mucus plugs/plaques. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
36 Samples
Download data: CEL
Series
Accession:
GSE47548
ID:
200047548
12.

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration [left lobe only]

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84; and Livraghi-Butrico et al. 2012, Mucosal Immunology 5(4):397-408). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE47546
ID:
200047546
13.

Role of Gq/11 and G12/13 signalling in Type II alveolar epithelial cells

(Submitter supplied) We have used microarrays to identify individual genes and pathways regulated by Gq/11 or G12/13 signalling in type II alveolar epithelial cells isolated from the lungs of knockout mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE87842
ID:
200087842
14.

Expression data of lung tissues from ICR mice treated with or without single-walled carbon nanotubes (SWCNTs)

(Submitter supplied) The SWCNTs can induce airway hyper-responsiveness (AHR) and chronic obstructive pulmonary disease (COPD)-like changes in mice model. The SWCNTs can induce clusters of proteinases, chemokines/cytokines, and macrophage receptors triggered signaling, which might play critical roles in the SWCNTs-induced pathological changes, including chronic inflammation and tissues remodeling. We used microarrays to detail the global programme of gene expression underlying and identified distinct classes of up-regulated genes during this process.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE22856
ID:
200022856
15.

Cigarette smoking alters mRNA expression in human alveolar macrophages

(Submitter supplied) Alveolar macrophages from never smokers and active smokers were isolated by bronchoalveolar lavage and gene expression was measured. Chronic cigarette smoke exposure, as occurs in smoker's lungs, leads to significant changes in gene expression. Of note, RNA was isolated immediately following bronchoscopy. Alveolar macrophage levels were >95%.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
8 Samples
Download data: CEL
Series
Accession:
GSE34517
ID:
200034517
16.

RNA-Seq of vocal folds of rabbits exposed to a low relative humidity environment

(Submitter supplied) The purpose of this study is to investigate if acute mucosal dehydration as a funcition of low relative humidty environment impacts the vocal folds at the mRNA level. Rabbits were used as animal model to enable a systematic and rigorous assessment of the pathobiology of vocal fold hydration since they can be manipulated in a physiologically realistic manner. We anticipate that the results of this study will help to elucidate the effects of altered mucosal hydration state in response to low ambient humidity on vocal fold epithelium, lamina propria and muscle tissue at the transcriptome level. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26786
12 Samples
Download data: TSV
Series
Accession:
GSE148588
ID:
200148588
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