GEO DataSets

(Submitter supplied) To better understand the biological pathways by which UV inactivated SARS-CoV-induced pulmonary eosinophilia occurs, we examined global transcriptional changes in macrophages from the lungs of mouse.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

24 Samples

Download data: TXT

(Submitter supplied) To better understand the biological pathways by which UV inactivated SARS-CoV-induced pulmonary eosinophilia occurs, we examined global transcriptional changes in mouse lungs.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

24 Samples

Download data: TXT

(Submitter supplied) Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease leading to death in 10% of the infected people. A mouse adapted SARS-CoV lacking the envelope (E) protein (rSARS-CoV-MA15-ΔE) is attenuated in vivo. To identify E protein domains and host responses that contribute to rSARS-CoV-MA15-ΔE attenuation, several mutants (rSARS-CoV-MA15-E*) containing point mutations or deletions in the amino-terminal or the carboxy-terminal regions of E protein, respectively, were generated. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

15 Samples

Download data: TXT

(Submitter supplied) The purpose is to determine the role of TLR3-/- on the regulation of the host immune response during lethal SARS-CoV infection

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

52 Samples

Download data: TXT

(Submitter supplied) Purpose of experiment was to perform transcriptomic analysis on C57Bl/6 mice infected with different doses of SARS CoV MA15 at 4 different days post infection.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

92 Samples

Download data: TXT

(Submitter supplied) To further investigate the underlying mechanisms of severe acute respiratory syndrome (SARS) pathogenesis and evaluate the therapeutic efficacy of potential drugs and vaccines it is necessary to use an animal model that is highly representative of the human condition in terms of respiratory anatomy, physiology and clinical sequelae. The ferret, Mustela putorius furo, supports SARS-CoV replication and displays many of the symptoms and pathological features seen in SARS-CoV-infected humans. more...

Organism:

Mustela putorius furo; Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

38 Samples

Download data: CEL

(Submitter supplied) This purpose of this experiment was to investigate the transcriptional differences between mice infected with SARS MA15 or SARS nsp16 mutant viruses.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

40 Samples

Download data: TXT

(Submitter supplied) The mechanisms by which pulmonary lesions and fibrosis are generated during SARS-CoV infection are not known. Using high-throughput mRNA profiling, we examined the transcriptional response of wild-type (WT), type I interferon receptor knockout (IFNAR1−/−), and STAT1 knockout (STAT1−/−) mice infected with a recombinant mouse-adapted SARS-CoV (rMA15) to better understand the contribution of specific gene expression changes to disease progression.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

36 Samples

Download data: TXT

(Submitter supplied) Since December 2019, the novel human Coronavirus SARS-CoV-2 has spread globally, causing millions of deaths. Unprecedented efforts have enabled development and authorization of a range of vaccines, which reduce transmission rates and confer protection against the associated disease COVID-19. These vaccines are conceptually diverse, including e.g. classical adjuvanted whole-inactivated virus, viral vectors, and mRNA vaccines. more...

Organism:

Mesocricetus auratus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL29592

16 Samples

Download data: CSV

(Submitter supplied) Severe acute respiratory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exacerbated inflammatory response and extensive lung pathology. To address the relevance of small non-coding RNAs in SARS-CoV pathology, we deep sequenced RNAs from the lungs of infected mice and discovered three 18–22 nt small viral RNAs (svRNAs). The three svRNAs were derived from the nsp3 (svRNA-nsp3.1 and -nsp3.2) and N (svRNA-N) genomic regions of SARS-CoV. more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL15103

16 Samples

Download data: TXT

(Submitter supplied) Background: Type I interferons (IFNs) are essential to the clearance of viral diseases, in part by initiating upregulation of IFN regulated genes (IRGs). A clear distinction between genes upregulated directly by virus and genes upregulated by secondary IFN production has not been made. Here we investigated the genes regulated by IFN-a2b compared to the genes regulated by SARS-CoV infection in ferrets. more...

Organism:

Canis lupus familiaris; Mustela putorius furo

Type:

Expression profiling by array

Platform:

GPL3738

43 Samples

Download data: CEL

(Submitter supplied) Recent epidemiological studies suggest that individuals with Down syndrome are more susceptible to SARS-CoV-2 infection and have higher rates of hospitalization and mortality than the general population. However, the main drivers behind these disparate health outcomes remain unknown. Herein we performed experimental infections with SARS-CoV-2 in a well-established mouse model of Down syndrome, Dp(16)1Yey/+;Tg(K18-ACE2)2Prlmn/+ (abbreviated as Dp16;ACE2). more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

18 Samples

Download data: XLS

(Submitter supplied) Infectious pneumonias exact an unacceptable mortality burden worldwide. Efforts to protect populations from pneumonia have historically focused on antibiotic development and vaccine-enhanced adaptive immunity. However, we have recently reported that the lungs’ innate defenses can be therapeutically induced by inhalation of a combination of synthetic TLR ligands that synergize to protect mice against otherwise lethal pneumonia. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

32 Samples

Download data: TXT

(Submitter supplied) Infectious pneumonias exact an unacceptable mortality burden worldwide. Efforts to protect populations from pneumonia have historically focused on antibiotic development and vaccine-enhanced adaptive immunity. However, we have recently reported that the lungs’ innate defenses can be therapeutically induced by inhalation of a bacterial lysate that protects mice against otherwise lethal pneumonia. Here, we tested in mice the hypothesis that Toll-like receptors (TLRs) are required for this antimicrobial phenomenon, and found that resistance could not be induced in the absence of the TLR signaling adaptor protein MyD88. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

22 Samples

Download data: TXT