GEO DataSets

(Submitter supplied) Cobalt is a transition group metal present in trace amounts in the human diet, but in larger doses it can be acutely toxic or cause adverse health effects in chronic, long term exposures. Its use in many industrial processes and alloys worldwide presents opportunities for occupational exposures, as well as exposures to military personnel. While the toxic effects of cobalt have been widely studied, the exact mechanisms of toxicity remain unclear. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS4953 GDS4954

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of MH1C1 liver cells exposed to 160 or 310 uM cobalt chloride. Cobalt (Co) is a heavy metal found naturally in low concentrations and used in military and industrial applications. Co exposure can result in adverse health effects. Results provide insight into the mechanisms of Co toxicity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 3 dose sets

Platform:

GPL1355

Series:

GSE51207

12 Samples

Download data: CEL

Analysis of H4IIEC3 liver cells exposed to 29 or 62 uM cobalt chloride. Cobalt (Co) is a heavy metal found naturally in low concentrations and used in military and industrial applications. Co exposure can result in adverse health effects. Results provide insight into the mechanisms of Co toxicity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 3 dose sets

Platform:

GPL1355

Series:

GSE51207

12 Samples

Download data: CEL

(Submitter supplied) Many heavy metals, including nickel (Ni), cadmium (Cd), and chromium (Cr) are toxic industrial chemicals with an exposure risk in both occupational and environmental settings that may cause harmful outcomes. While these substances are known to produce adverse health effects leading to disease or health problems, the detailed mechanisms remain unclear. To elucidate the processes involved in the of toxicity of nickel, cadmium, and chromium at the molecular level and to perform a comparative analysis, H4-II-E-C3 rat liver-derived cell lines were treated with soluble salts of each metal using concentrations derived from viability assays, and gene expression patterns were determined with DNA microarrays. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3928

Platform:

GPL1355

44 Samples

Download data: CEL

Analysis of H4-II-E-C3 liver-derived cells exposed to toxic heavy metals: nickel II chloride (NiCl2), cadmium chloride (CdCl2), or sodium dichromate (Na2Cr2O7), at various concentrations (based on viability assays). Results provide insight into molecular mechanisms underlying Ni, Cd and Cr toxicity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 4 agent, 10 dose sets

Platform:

GPL1355

Series:

GSE31503

44 Samples

Download data: CEL

(Submitter supplied) Methylmercury (MeHg) is a highly toxic environmental pollutant. To understand the mechanisms of toxicity of the compound and possibly to discover new biomarkers for environmental monitoring, we have conducted toxicogenomics studies. We designed 126k-cod-oligonucleotide arrays and performed genome-wide gene expression assays in liver samples from juvenile cod treated with MeHg (0.5 and 2 mg/kg body weight). more...

Organism:

Gadus morhua

Type:

Expression profiling by array

Platform:

GPL15700

15 Samples

Download data: PAIR

(Submitter supplied) The purpose of this work was to identify the potential signatures of cobalt exposure using a toxicogenomic approach. A time course transcriptome analysis was performed on human type II epithelial cell line A549. Cells were exposed to cobalt at midlog phase ; a medium without FCS containing cobalt (CoCl2, Sigma) or not was added for 30mn, 2h, 4h or 24h. Total RNA was isolated using the Quiagen RNeasy miniprep kit, and then labelled using the FairPlay Microarray Labelling Kit (Stratagene). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4263

30 Samples

Download data

(Submitter supplied) A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to pursue a holistic understanding of the effects of the explosives degradation product 2-amino-4,6-dinitrotoluene (2A-DNT) dosing on the health of the wildlife bird model, Northern bobwhite (Colinus virginianus). A subchronic 60d toxicology bioassay was leveraged where both sexes were dosed via daily gavage with 0, 3, 14, or 30 mg/kg-d 2-ADNT. more...

Organism:

Colinus virginianus

Type:

Expression profiling by array

Platform:

GPL9548

64 Samples

Download data: TXT

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Background: Exposure to dichlorvos (DDVP), an organophosphorus pesticide, is known to result in neurotoxicity as well as other metabolic perturbations. However, the molecular causes of DDVP toxicity are poorly understood, especially in cells other than neurons and muscle cells. To obtain a better understanding of the process of non-neuronal DDVP toxicity, we exposed zebrafish to different concentrations of DDVP, and investigated the resulting changes in liver histology and gene transcription. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL7301

32 Samples

Download data: GPR, TXT

(Submitter supplied) Comparison of transcriptional profiles after exposure of HaCaT cells to WC or WC-Co nanoparticles and respective amount of free cobalt in form of CoCl2 after 3 hours and 3 days of exposure. Genes responding especially to nanoparticles or leached cobalt ions should be determined.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

40 Samples

Download data: TXT

(Submitter supplied) Background: Signal Transducer and Activator of Transcription 1 (STAT1) has traditionally been regarded as a transmitter of interferon signaling and a pro-apoptotic tumor suppressor. Recent data have identified new functions of STAT1 associated with tumorigenesis and resistance to genotoxic stress, including ionizing radiation (IR) and chemotherapy. To investigate the mechanisms contributing to the tumorigenic functions of STAT1, we performed a combined transcriptomic-proteomic expressional analysis and found that STAT1 is associated with regulation of energy metabolism. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

8 Samples

Download data: CEL

(Submitter supplied) This study aimed to quantify and compare the mRNA abundance of major xenobiotic processing genes in liver following activation of PXR and CAR using RNA-Seq

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

9 Samples

Download data: ZIP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16524

96 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling in skeletal muscle of 48 pigs (132 days of age) originated from two lines divergently selected for residual feed intake (RFI) : low-RFI pigs (RFIneg), high-RFI pigs (RFIpl). Both lines were offered isocaloric and isoproteic diets with contrasted energy source and nutrients: low fat, low fiber (LF) diet or a high fat, high fiber (HF)diet during 10 weeks. Effects of RFI selection, diet and interaction between diet and line were investigated.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16524

48 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling in liver of 48 pigs (132 days of age) originated from two lines divergently selected for residual feed intake (RFI) : low-RFI pigs (RFIneg), high-RFI pigs (RFIpl). Both lines were offered isocaloric and isoproteic diets with contrasted energy source and nutrients: low fat, low fiber (LF) diet or a high fat, high fiber (HF)diet during 10 weeks. Effects of RFI selection, diet and interaction between diet and line were investigated.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16524

48 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16524

144 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling in peritoneal adipose tissue of 48 pigs (132 days of age) originated from two lines divergently selected for residual feed intake (RFI) : low-RFI pigs (RFIneg), high-RFI pigs (RFIpl). Both lines were offered isocaloric and isoproteic diets with contrasted energy source and nutrients: low fat, low fiber (LF) diet or a high fat, high fiber (HF)diet during 10 weeks. Effects of RFI selection, diet and interaction between diet and line were investigated.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16524

48 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling in subcutaneous adipose tissue of 48 pigs aged (132 days of age) originated from two lines divergently selected for residual feed intake (RFI) : low-RFI pigs (RFIneg), high-RFI pigs (RFIpl). Both lines were offered isocaloric and isoproteic diets with contrasted energy source and nutrients: low fat, low fiber (LF) diet or a high fat, high fiber (HF)diet during 10 weeks. Effects of RFI selection, diet and interaction between diet and line were investigated.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16524

48 Samples

Download data: TXT