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Links from GEO DataSets

Items: 18

1.

Genome-wide analysis of gene expression in mouse spleen stroma

(Submitter supplied) Comparison between gene expression profiles of splenic stroma from wild type and lymphotoxin beta receptor knockout mice. The goal was to identify a set of genes which expression in splenic stroma is under lymphotoxin control and which can potentially be important for proper stroma development and function in secondary lymphoid organs.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
8 Samples
Download data: IDAT, JPG, SDF, TIFF, TXT, XML
Series
Accession:
GSE52294
ID:
200052294
2.

sLTbetaR-Ig treated mLN

(Submitter supplied) treatment of mesenteric lymph nodes with soluble lymphotoxin-beta receptor for 0,1,2,3,27 and 35 days Keywords: time-course
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS2004 GDS2005
Platforms:
GPL340 GPL339
36 Samples
Download data: CEL
Series
Accession:
GSE2124
ID:
200002124
3.

FDC-E vs FDC-D

(Submitter supplied) Comparison of follicular dendritic cell-enriched versus -depleted splenocytes Keywords: parallel sample
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS1585 GDS1599 GDS1600
Platforms:
GPL81 GPL82 GPL83
14 Samples
Download data: CEL
Series
Accession:
GSE2123
ID:
200002123
4.
Full record GDS2005

Lymphotoxin-beta receptor signaling inhibition effect on lymph nodes: time course (MG-430B)

Analysis of lymph nodes from animals treated with soluble lymphotoxin-beta receptor (LTbetaR)-immunoglobulin fusion protein (LTbetaR-Ig) for up to 35 days. LTbetaR-Ig inhibits LTbetaR activation, important in the differentiation of lymphoid germinal centers and follicular dendritic cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 6 time sets
Platform:
GPL340
Series:
GSE2124
18 Samples
Download data: CEL
DataSet
Accession:
GDS2005
ID:
2005
5.
Full record GDS2004

Lymphotoxin-beta receptor signaling inhibition effect on lymph nodes: time course (MG-430A)

Analysis of lymph nodes from animals treated with soluble lymphotoxin-beta receptor (LTbetaR)-immunoglobulin fusion protein (LTbetaR-Ig) for up to 35 days. LTbetaR-Ig inhibits LTbetaR activation, important in the differentiation of lymphoid germinal centers and follicular dendritic cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 6 time sets
Platform:
GPL339
Series:
GSE2124
18 Samples
Download data: CEL
DataSet
Accession:
GDS2004
ID:
2004
6.
Full record GDS1600

Follicular dendritic cell enriched splenocytes (MG U74C)

Analysis of follicular dendritic cell (FDCs) enriched splenocytes. FDCs are important in the formation of lymphoid germinal centers (GCs), where rapid B-cell proliferation and differentiation occur. Results identify transcripts that are overrepresented in cells associated with FDC networks in GCs.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell type sets
Platform:
GPL83
Series:
GSE2123
5 Samples
Download data: CEL
DataSet
Accession:
GDS1600
ID:
1600
7.
Full record GDS1599

Follicular dendritic cell enriched splenocytes (MG U74B)

Analysis of follicular dendritic cell (FDCs) enriched splenocytes. FDCs are important in the formation of lymphoid germinal centers (GCs), where rapid B-cell proliferation and differentiation occur. Results identify transcripts that are overrepresented in cells associated with FDC networks in GCs.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell type sets
Platform:
GPL82
Series:
GSE2123
4 Samples
Download data: CEL
DataSet
Accession:
GDS1599
ID:
1599
8.
Full record GDS1585

Follicular dendritic cell enriched splenocytes (MG U74A)

Analysis of follicular dendritic cell (FDCs) enriched splenocytes. FDCs are important in the formation of lymphoid germinal centers (GCs), where rapid B-cell proliferation and differentiation occur. Results identify transcripts that are overrepresented in cells associated with FDC networks in GCs.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell type sets
Platform:
GPL81
Series:
GSE2123
5 Samples
Download data: CEL
DataSet
Accession:
GDS1585
ID:
1585
9.

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation

(Submitter supplied) In human chronic lymphocytic leukemia (CLL) pathogenesis B cell antigen receptor signaling seems important for leukemia B cell ontogeny, whereas the microenvironment influences B cell activation, tumor cell lodging and provision of antigenic stimuli. Using the murine Eμ-Tcl1 CLL model, we demonstrate that CXCR5-controlled access to follicular dendritic cells (FDCs) confers proliferative stimuli to leukemia B cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL19138
18 Samples
Download data: CEL
Series
Accession:
GSE60925
ID:
200060925
10.

Lymphtoxin pathway effects on thymic medullary epithelial cells

(Submitter supplied) We compared gene expression profiles of lymphotoxin alpha- and lymphtoxin beta receptor-deficient thymic medullary epithelial cells with their wild-type littermates, as well as with Aire-deficient and wild-type littermates. This was done in order to determine whether there was overlap in the effects of lymphotoxin and aire. Keywords: genetic modification
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
18 Samples
Download data: CEL
Series
Accession:
GSE8563
ID:
200008563
11.

primary FDC

(Submitter supplied) expression profiles of FDC and BMDC are compared Keywords: cell type comparison
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data
Series
Accession:
GSE4535
ID:
200004535
12.

Trancriptional profile of WT and Notch2 cDC2s after immunization with SRBC

(Submitter supplied) To determine any expresssion changes in cDC2s from WT and CD11c-Cre Notch2f/f mice immunized with sheep red blood cells
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
10 Samples
Download data: CEL
Series
Accession:
GSE119242
ID:
200119242
13.

Gene expression data of diagnostic childhood T-ALL samples and human thymocytes

(Submitter supplied) Lymphotoxin-mediated activation of the lymphotoxin-β receptor (LTβR) has been implicated in several physiological and pathological processes, including lymphoid organ development, T-cell maturation, and solid and hematopoietic malignancies. Its role in T-cell acute lymphoblastic leukemia (T-ALL) or other T-cell malignancies has remained however to be investigated. Here we show that the genes encoding lymphotoxin (LT)-α and LTβ were expressed in T-ALL patient samples, more abundantly in the TAL/LMO molecular subtype, and in the TEL-JAK2 mouse model of cortical/mature T-ALL. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
10 Samples
Download data: CEL
Series
Accession:
GSE66638
ID:
200066638
14.

PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL570 GPL6244
87 Samples
Download data: CEL
Series
Accession:
GSE51001
ID:
200051001
15.

Gene expression data of diagnostic childhood T-ALL samples

(Submitter supplied) The PI3K pathway is frequently hyperactivated in primary T-cell acute lymphoblastic leukemia (T-ALL) cells. Activation of the PI3K pathway has been suggested as one mechanism of glucocorticoid resistance in T-ALL, and patients harboring mutations in the PI3K negative regulator PTEN may be at increased risk of induction failure and relapse. In this study, we identified Myc as an important downstream integrator of PI3K pathway activity in T-ALL and we provide data supportive of an association of higher PI3K activity with glucocorticoid resistance and worse clinical outcome. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
43 Samples
Download data: CEL
Series
Accession:
GSE50999
ID:
200050999
16.

TNFa and LTB stimulated UM-SCC 46 gene expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL18387
12 Samples
Download data: IDAT
Series
Accession:
GSE126905
ID:
200126905
17.

TNFα and LTβ stimulated UM-SCC 46 gene expression [TNF]

(Submitter supplied) To investigate the regulatory mechanisms and targets of the activation of NF-kB and inflammatory pathways, we treated HPV(-) head and neck cancer line UM-SCC 46 cells with TNFα and LTβ at different time points, and compared the gene expression by microarray. TNFα uniquely induced 172 genes, LTβ specifically induced 202 genes, while 155 genes were induced by both ligands. Total RNA samples were isolated from UM-SCC 46 cells after TNFα or LTβ treatment at different time points, and the gene expression were compared with untreated cell controls.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL18387
6 Samples
Download data: IDAT, XLSX
Series
Accession:
GSE126904
ID:
200126904
18.

TNFα and LTβ stimulated UM-SCC 46 gene expression [LTB]

(Submitter supplied) To investigate the regulatory mechanisms and targets of the activation of NF-kappaB and inflammatory pathways, we treated HPV(-) head and neck cancer line UM-SCC 46 cells with TNFα and LTβ at different time points, and compared the gene expression by microarray. TNFα uniquely induced 172 genes, LTβ specifically induced 202 genes, while 155 genes were induced by both ligands. Total RNA samples were isolated from UM-SCC 46 cells after TNFα or LTβ treatment at different time points, and the gene expression were compared with untreated cell controls.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL18387
6 Samples
Download data: IDAT, XLSX
Series
Accession:
GSE126903
ID:
200126903
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