Similar studies for GEO DataSets (Select 200053371) - GEO DataSets

Select item 2000533711.

Neuroblastoma: MYCN normal vs. MYCN amplified

(Submitter supplied) To evaluate the expression of genes associated with MYCN in NB, 10 tumors with MYCN amplification and 10 with normal MYCN copy number were subjected to oligonucleotide microarray using Agilent oligo microarray chips.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL887
20 Samples

Download data: TXT

Series

Accession:: GSE53371

ID:: 200053371

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000392182.

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.

(Submitter supplied) Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is amplified in 20% of neuroblastomas, and these tumors carry a poor prognosis. However, tumors without MYCN amplification also may have a poor outcome. Here, we identified downstream targets of MYCN by shRNA-mediated silencing MYCN in neuroblastoma cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
11 Samples

Download data: CEL

Series

Accession:: GSE39218

ID:: 200039218

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Select item 2000276083.

Exon array analysis reveals neuroblastoma tumors have distinct alternative splicing patterns according to stage and MYCN amplification status

(Submitter supplied) This dataset contains Human Exon 1.0 ST Array data from 47 neuroblastoma samples

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5188
47 Samples

Download data: CEL

Series

Accession:: GSE27608

ID:: 200027608

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Select item 2002243914.

AhR promotes dedifferentiation in MYCN amplified neuroblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
36 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE224391

ID:: 200224391

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Select item 2002243905.

AhR promotes dedifferentiation in MYCN amplified neuroblastoma [ATAC-seq]

(Submitter supplied) Neuroblastoma cell lines (Kelly, BE2C) were subject to chromatin profiling by ATAC-seq ATAC-seq analysis of Neuroblastoma cell lines +/- shAhR knockdown

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
18 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE224390

ID:: 200224390

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Select item 2002240376.

AhR promotes dedifferentiation in MYCN amplified neuroblastoma [RNA-seq]

(Submitter supplied) AhR promotes dedifferentiation in MYCN amplified neuroblastoma

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
18 Samples

Download data: CSV

Series

Accession:: GSE224037

ID:: 200224037

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Select item 2001937677.

BRD4 inhibitor MZ1 exerts anti-cancer effects in Neuroblastoma

(Submitter supplied) MZ1 is a newly designed pan-BET-targeting PROTAC that binds to target proteins (BET proteins such as BRD2, BRD3, and BRD4) and recruits them to the ubiquitin/protease pathway for selective destruction. However, the role of MZ1 in NB models has yet to be determined. The effect of MZ1 on NB cells was investigated using RNA-seq analysis in this work. MZ1 is a newly designed pan-BET-targeting PROTAC that binds to target proteins (BET proteins such as BRD2, BRD3, and BRD4) and recruits them to the ubiquitin/protease pathway for selective destruction. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
4 Samples

Download data: TXT

Series

Accession:: GSE193767

ID:: 200193767

Select item 2002084248.

The cooperation between MYCN and its cofactors WDR5 and G9a

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18573 GPL20301 GPL24676
56 Samples

Download data: BW

Series

Accession:: GSE208424

ID:: 200208424

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Select item 2002084239.

RNA-sequencing analysis to identify genes regulated by MYCN in rhabdomyosarcoma cell line RH4

(Submitter supplied) In this study we identified genes regulated by MYCN in RH4 cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: TXT

Series

Accession:: GSE208423

ID:: 200208423

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Select item 20020842210.

RNA-sequencing analysis to identify genes regulated by MYCN in neuroblastoma cell line SHEP by MYCN overexpression

(Submitter supplied) In this study we identified genes regulated by MYCN in SHEP cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
6 Samples

Download data: TXT

Series

Accession:: GSE208422

ID:: 200208422

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Select item 20020842111.

RNA-sequencing analysis to identify genes regulated by MYCN in neuroblastoma cell line KCNR.

(Submitter supplied) In this study we identified genes regulated by MYCN in KCNR cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: TXT

Series

Accession:: GSE208421

ID:: 200208421

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Select item 20020842012.

RNA-sequencing analysis to identify genes regulated by MYCN, WDR5 and G9a in neuroblastoma cell line IMR32

(Submitter supplied) In this study we identified genes regulated by MYCN, WDR5 and G9a in IMR32 cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: TXT

Series

Accession:: GSE208420

ID:: 200208420

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Select item 20020841913.

The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siWDR5]

(Submitter supplied) MYCN cooperates with WDR5 to activate canonical MYC targets and cooperates with G9a to repress neuronal differentiation genes.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: BW

Series

Accession:: GSE208419

ID:: 200208419

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Select item 20020841714.

The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siG9a]

(Submitter supplied) MYCN cooperates with WDR5 to activate canonical MYC targets and cooperates with G9a to repress neuronal differentiation genes.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: BW

Series

Accession:: GSE208417

ID:: 200208417

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Select item 20020841415.

The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siMYCN]

(Submitter supplied) MYCN cooperates with WDR5 to activate canonical MYC targets and cooperates with G9a to repress neuronal differentiation genes.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
16 Samples

Download data: BW

Series

Accession:: GSE208414

ID:: 200208414

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Select item 20018423216.

Investigate the effect of gain of HAND2 on chromatin accessibility.

(Submitter supplied) The overexpression of HAND2 in IMR32 cells results in a increase of chromation accessibility at the HAND2 and MYCN common binding sites.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: BW

Series

Accession:: GSE184232

ID:: 200184232

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Select item 20018422917.

Investigate the effect of loss of HAND2, MYCN, PHOX2B and GATA3 on chromatin accessibility.

(Submitter supplied) The knockdown of HAND2 in IMR32 cells results in a decrease of chromation accessibility at the HAND2 and MYCN common binding sites.