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Links from GEO DataSets

Items: 20

1.

MiRNA expression profile in the aortas of Apoe-/- mice with an specific knock-out of Dicer in endothelial cells compared to control mice after 4 weeks of a high-fat diet

(Submitter supplied) Increased monocyte adhesion to dysfunctional endothelial cells (ECs) orchestrated by chemokines plays an important role in arterial inflammation during atherosclerosis. Endothelial microRNAs (miRNAs) processed by the RNase Dicer1 determine the phenotype of ECs by posttranscriptional regulation of gene expression. However, the impact of endothelial miRNAs on endothelial inflammation and atherosclerosis is currently unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL18082
6 Samples
Download data: TXT
Series
Accession:
GSE53435
ID:
200053435
2.

MiRNA profiling in aortas of Apoe-/- mice with an specific knock-out of Dicer in endothelial cells compared to control mice after 12 weeks of a high-fat diet

(Submitter supplied) Increased monocyte adhesion to dysfunctional endothelial cells (ECs) orchestrated by chemokines plays an important role in arterial inflammation during atherosclerosis. Endothelial microRNAs (miRNAs) processed by the RNase Dicer1 determine the phenotype of ECs by posttranscriptional regulation of gene expression. However, the impact of endothelial miRNAs on endothelial inflammation and atherosclerosis is currently unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL18082
6 Samples
Download data: TXT
Series
Accession:
GSE53433
ID:
200053433
3.

MiRNA expression profile in murine

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
28 Samples
Download data
Series
Accession:
GSE34648
ID:
200034648
4.

MiRNA expression profile in murine advanced atherosclerotic plaque compared with early atherosclerotic plaque

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
7 Samples
Download data: XLSX
Series
Accession:
GSE34647
ID:
200034647
5.

MiRNA expression profile in murine un-diseased arterial tissue on 3 month high fat diet vs 10 month high fat diet

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
7 Samples
Download data: XLSX
Series
Accession:
GSE34646
ID:
200034646
6.

MiRNA expression profile in murine early atherosclerotic plaque compared with un-diseased arterial tissue

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
8 Samples
Download data: XLSX
Series
Accession:
GSE34645
ID:
200034645
7.

MiRNA expression profile in murine advanced atherosclerotic plaque compared with un-diseased arterial wall

(Submitter supplied) Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
6 Samples
Download data: XLSX
Series
Accession:
GSE34644
ID:
200034644
8.

Expression profiling of Dicer loss-of-function macrophages

(Submitter supplied) The role of microRNAs in the inflammatory response of macrophages to LPS was adressed by expression analysis in DicerKO (LysMcre/+;Dicerfl/fl;ApoE-/-) vs wildtype (LysMcre/+;Dicer+/+ApoE-/-) macrophages when challenged either with vehicle (PBS) or LPS.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
12 Samples
Download data: TXT
Series
Accession:
GSE106854
ID:
200106854
9.

Ago2-RIP-chip and miRNA expression profile in Dicer WT and KO macrophages from bone marrow or aorta

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR; Other
Platforms:
GPL15053 GPL13912 GPL18082
18 Samples
Download data: TXT
Series
Accession:
GSE87721
ID:
200087721
10.

miRNA expression profile in aortas from LysM-Cre/Dicerflox/flox/Apoe–/– mice compared with LysM-Cre/Dicerwt/wt/Apoe–/– mice fed with high-fat diet for 12 weeks

(Submitter supplied) The global change of the miRNA expression profile during atherosclerosis is due to the infiltration of different types of leukocytes into the arterial vessel wall in addition to disease-specific regulation in vascular cells. Monocyte-derived macrophage accumulation in the subintimal region is critical in the formation of atherosclerotic plaques. However, the role of Dicer, the key enzyme for miRNA biogenesis, during the development of atherosclerosis is currently unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15053
6 Samples
Download data: TXT
Series
Accession:
GSE87719
ID:
200087719
11.

miRNA expression profiles in Dicer WT and KO bone marrow-derived macrophages

(Submitter supplied) The global change of the miRNA expression profile during atherosclerosis is due to the infiltration of different types of leukocytes into the arterial vessel wall in addition to disease-specific regulation in vascular cells. Monocyte-derived macrophage accumulation in the subintimal region is critical in the formation of atherosclerotic plaques. However, the role of Dicer, the key enzyme for miRNA biogenesis, during the development of atherosclerosis is currently unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL18082
6 Samples
Download data: TXT
Series
Accession:
GSE87718
ID:
200087718
12.

Ago2-RIP-chip in Dicer WT and KO macrophages

(Submitter supplied) To determine the spectrum of miRNA targets regulated following Dicer deletion, we performed argonaute 2 (AGO2)-RNA Immunoprecipitation (RIP)-microarray in bone marrow-derived macrophages (BMDMs) from LysM-Cre/Dicerflox/flox/Apoe–/– and LysM-Cre/Dicerwt/wt/Apoe–/– mice. This analysis combined with miRNA profiling in Dicer wild type (WT) and knockout (KO) BMDMs may help to identify the miRNA targets regulated by Dicer deletion.
Organism:
Mus musculus
Type:
Other
Platform:
GPL13912
6 Samples
Download data: TXT
Series
Accession:
GSE87717
ID:
200087717
13.

Regulation of Activation-Associated mRNA and MicroRNA Accumulation Rates during Monocyte-to-Macrophage Differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platforms:
GPL19055 GPL14851
57 Samples
Download data
Series
Accession:
GSE60550
ID:
200060550
14.

Regulation of Activation-Associated Transcripts Accumulation Rates during Monocyte-to-Macrophage Differentiation

(Submitter supplied) We profiled macrophage activation-associated transcripts using TaqMan assays in a Fluidigm 48.48 Gene Expression Array to identify transcripts with expression levels that were affected by differences in culturing conditions during monocyte-to-macrophage differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL19055
48 Samples
Download data: TXT, XLS
Series
Accession:
GSE60549
ID:
200060549
15.

Regulation of Activation-Associated MicroRNA Accumulation Rates during Monocyte-to-Macrophage Differentiation

(Submitter supplied) We profiled miRNA expression using TaqMan TLDA assays to identify miRNAs with expression levels that were affected by differences in culturing conditions during monocyte-to-macrophage differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL14851
9 Samples
Download data: TXT
Series
Accession:
GSE60110
ID:
200060110
16.

MiR expression profiles in M1-polarized compared with unstimulated (MФ) bone marrow-derived macrophage cells

(Submitter supplied) The global change of the miR expression profile during atherosclerosis is due to the infiltration of different types of leukocytes into the arterial vessel wall in addition to disease-specific regulation in vascular cells. Monocyte-derived macrophage accumulation in the subintimal region is critical in the formation of atherosclerotic plaques. It is currently unknown which miRs are involved in the atherogenic macrophage response. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL15673
10 Samples
Download data: TXT
Series
Accession:
GSE33453
ID:
200033453
17.

Changes in miR expression profile carotid plaques induced by acutely induced flow disturbances in apoe-/- mice on a high fat diet.

(Submitter supplied) Atherosclerosis is causally related to disturbed flow through low and oscillatory shear stress. In order to study the miR expression profile in atherosclerotic plaques induced by disturbed flow, partial ligation of the carotid artery was performed. This procedure results acutely in severly reduced blood flow and in stenotic lesion formation within 6 weeks in apoe-/- mice on a high fat diet. We compared the miR expression profile in partially ligated left carotid arteries with the untreated right carotid artery to identify miRs which are involved in plaque formation through flow disturbances.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL11419
12 Samples
Download data: TXT
Series
Accession:
GSE26555
ID:
200026555
18.

Microarray profiling reveals broad and differential effects of RBM3 on miRNA expression.

(Submitter supplied) MicroRNAs (miRNAs) are a family of short, noncoding RNAs that regulate translation of mRNAs by mechanisms involving the binding of complementary sequences. The influence of miRNAs on the proteome and cellular events is extensive as they regulate an estimated 60% of the transcriptome and play key roles in differentiation, plasticity, circadian rhythm, immunity, and disease. The post-transcriptional biogenesis of most miRNAs involves a sequential cleavage process mediated by RNase III family enzymes. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL8824
4 Samples
Download data: TXT
Series
Accession:
GSE33519
ID:
200033519
19.

Comparison of gene expression in aorta and CD115+ isolated circulating cells from apoE-/- versus apoE-/-LTbR-/- mice

(Submitter supplied) Affymetrix Microarrays were used to analyse gene expression in aortas and circulating CD115+ cells of ApoE- and ApoE/Lymphotoxin beta receptor (LTbR)-double-deficent mice fed a Western diet from 8 to 12 weeks of age in order to identify regulated genes and pathways leading to reduced atherosclerosis in ApoE-/-/LTbR-/- mice compared to ApoE-/- littermate controls.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
14 Samples
Download data: CEL
Series
Accession:
GSE63259
ID:
200063259
20.

Role of miRNAs in the differentiation of human embryonic stem cells to an endothelial cell lineage

(Submitter supplied) To assess changes in the miRNA-ome during the early stages of endothelial differentiation, the expression of mature human miRNAs at days 2, 4 and 10 of endothelial differentiation (vs pluripotent time-matched samples) in SA461 hESC cell line was analysed in a two-channel microarray. Expression of the pluripotency-associated miRNAs miR-302a – d and miR-372 and miR-373 was significantly suppressed with progression of differentiation. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL14799
28 Samples
Download data: TXT
Series
Accession:
GSE33675
ID:
200033675
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